Skeletal Site-Specific Lipid Profile and Hematopoietic Progenitors of Bone Marrow Adipose Tissue in Patients Undergoing Primary Hip Arthroplasty DOI Creative Commons
Drenka Trivanović,

Marko Vujačić,

Aleksandra Arsić

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 16 - 16

Published: Jan. 4, 2025

Bone marrow adipose tissue (BMAT) has been described as an important biomechanic and lipotoxic factor with negative impacts on skeletal hematopoietic system regeneration. BMAT undergoes metabolic cellular adaptations age disease, being a source of potential biomarkers. However, there is no evidence the lipid profile cellularity at different locations in osteoarthritis patients undergoing primary hip arthroplasty. Acetabular femoral bone (BM) gluteofemoral subcutaneous (gfSAT) were obtained from matched replacement surgery. BM, BMAT, gfSAT explored levels total lipids, fatty acids, cells by using thin-layerand gas chromatography, ex vivo assays, flow cytometry. content was significantly higher than acetabular BM. Total analyses revealed lower triglyceride gfSAT. Frequencies saturated palmitic, myristic, stearic acids The CD45+CD34+ within or This associated incidence clonogenic progenitors late erythroid colonies CFU-E when compared to similar their BM counterparts. Collectively, our results indicate that profiles impose microenvironments distributions potential. These findings might bring forth new inputs for defining biology setting novel directions OA disease investigations.

Language: Английский

Skeletal Site-Specific Lipid Profile and Hematopoietic Progenitors of Bone Marrow Adipose Tissue in Patients Undergoing Primary Hip Arthroplasty DOI Creative Commons
Drenka Trivanović,

Marko Vujačić,

Aleksandra Arsić

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 16 - 16

Published: Jan. 4, 2025

Bone marrow adipose tissue (BMAT) has been described as an important biomechanic and lipotoxic factor with negative impacts on skeletal hematopoietic system regeneration. BMAT undergoes metabolic cellular adaptations age disease, being a source of potential biomarkers. However, there is no evidence the lipid profile cellularity at different locations in osteoarthritis patients undergoing primary hip arthroplasty. Acetabular femoral bone (BM) gluteofemoral subcutaneous (gfSAT) were obtained from matched replacement surgery. BM, BMAT, gfSAT explored levels total lipids, fatty acids, cells by using thin-layerand gas chromatography, ex vivo assays, flow cytometry. content was significantly higher than acetabular BM. Total analyses revealed lower triglyceride gfSAT. Frequencies saturated palmitic, myristic, stearic acids The CD45+CD34+ within or This associated incidence clonogenic progenitors late erythroid colonies CFU-E when compared to similar their BM counterparts. Collectively, our results indicate that profiles impose microenvironments distributions potential. These findings might bring forth new inputs for defining biology setting novel directions OA disease investigations.

Language: Английский

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