Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy

Published: June 3, 2024

Diabetes mellitus (DM) is the most common metabolic disease in humans, and its prevalence increasing worldwide parallel with obesity pandemic. A lack of insulin or resistance, consequently hyperglycemia, leads to many systemic disorders, among which diabetic encephalopathy (DE) a long-term complication central nervous system (CNS), characterized by cognitive impairment motor dysfunctions. The role oxidative stress neuroinflammation pathomechanism DE has been proven. Fractalkine (CX3CL1) unique properties as an adhesion molecule chemoattractant, acting on only receptor, CX3CR1, it regulates activity microglia physiological states neuroinflammation. Depending clinical context, CX3CL1-CX3CR1 signaling may have neuroprotective effects inhibiting inflammatory process or, conversely, maintaining/intensifying inflammation neurotoxicity. This review discusses evidence supporting that pair other neurotoxic. Interrupting vicious cycle within neuron-microglia interactions be therapeutic goal limiting response.

Language: Английский

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Correlation between thyroid hormone sensitivity and diabetic peripheral neuropathy in euthyroid patients with type 2 diabetes mellitus

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 23, 2024

Previous studies have revealed that thyroid hormone (TH) levels are associated with the risk of diabetic peripheral neuropathy (DPN) in euthyroid patients type 2 diabetes mellitus (T2DM). However, relationship between TH sensitivity, a complementary method for assessing function, and DPN remains unclear. This study aimed to investigate correlation sensitivity T2DM. Exactly 708 adults T2DM were retrospectively enrolled. The FT3/FT4 ratio was used estimate sensitivity. Central assessed using Thyrotroph T4 Resistance Index (TT4RI), Thyroid-Stimulating Hormone (TSHI), Thyroid Feedback Quantile-based (TFQI), Parametric TFQI (PTFQI). neurologic symptoms, signs, nerve conduction velocity tests. examined logistic regression analysis. We observed an elevated (OR = 1.36, 95%CI: 1.13–1.63, p 0.0012). For each standard deviation (SD) increase TT4RI, TSHI, TFQI, PTFQI, OR 0.80 (95%CI: 0.68–0.94, 0.0078), 0.72 0.60–0.86, 0.0002), 0.69 0.58–0.83, < 0.0001), 0.58–0.82, respectively. These results suggested reduced central is decreased developing DPN.

Language: Английский

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Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7527 - 7527

Published: July 9, 2024

Diabetes mellitus (DM) is the most common metabolic disease in humans, and its prevalence increasing worldwide parallel with obesity pandemic. A lack of insulin or resistance, consequently hyperglycemia, leads to many systemic disorders, among which diabetic encephalopathy (DE) a long-term complication central nervous system (CNS), characterized by cognitive impairment motor dysfunctions. The role oxidative stress neuroinflammation pathomechanism DE has been proven. Fractalkine (CX3CL1) unique properties as an adhesion molecule chemoattractant, acting on only receptor, CX3CR1, it regulates activity microglia physiological states neuroinflammation. Depending clinical context, CX3CL1-CX3CR1 signaling may have neuroprotective effects inhibiting inflammatory process or, conversely, maintaining/intensifying inflammation neurotoxicity. This review discusses evidence supporting that pair other neurotoxic. Therefore, interrupting vicious cycle within neuron–microglia interactions promoting neurotoxic axis be therapeutic goal limiting response. However, optimal approach prevent simply tight glycemic control, because elimination dysglycemic CNS abolishes fundamental mechanisms induce this cycle.

Language: Английский

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Prevalencia de Neuropatía en Pacientes Diabéticos que Acuden a Electromiografía en un Hospital Privado de Torreón, Coahuila

Estudios y Perspectivas Revista Científica y Académica, Journal Year: 2024, Volume and Issue: 4(3), P. 60 - 72

Published: Aug. 5, 2024

Este artículo analiza la prevalencia de Neuropatía diabética (ND) en pacientes que acuden a estudio electromiográfico un hospital privado Torreón, Coahuila, procedentes instituciones tanto públicas como privadas. El objetivo principal es determinar ND diabéticos electromiografía. Teniendo objetivos secundarios el insulinodependientes, gravedad y tiempo evolución Diabetes Mellitus (DM) estos pacientes. Para lograr objetivos, se elaboró transversal, analítico observacional, tamaño muestra 300 expedientes clínicos. Los resultados demuestran fue del 76%, teniendo rango 1 40 años. 88% los insulinodependientes presentan mayoría forma moderada severa. concuerdan con nacional ND, mayor evolución, discrepa mujeres versus hombres. Por lo tanto, podemos tiene una resto mundo. Es importante diagnóstico precoz para mejorar calidad vida paciente, no hubo diferencia entre son.

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