Effects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study DOI Creative Commons

Shuqing Wang,

Lin Ma, Song Wang

et al.

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 28, 2025

Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate effects sleep (ASD) on brain function migraine without aura (MWoA) via functional magnetic resonance imaging (fMRI). Twenty three MWoA and 23 healthy controls (HCs) were fairly included study. All participants underwent two MRI scans: one at baseline (prior deprivation) another following 24 h ASD. Images obtained blood-oxygen-level-dependent T1-weighted sequences a Siemens 7.0 T scanner. We conducted analyses changes low-frequency fluctuations (ALFF) values connectivity (FC) between networks within network before after ASD both group HC group. Additionally, we investigated relationship ALFF clinical features (VAS monthly days). In group, led significant increase left parahippocampal gyrus compared (p-FDR = 0.01). significantly greater 64 regions than baseline. most change detected right medial pulvinar thalamus 0.017), which showed negative correlation days. Moreover, seed-based (SBC) analysis using as seed point revealed increased cerebellar vermis (p-FWE 0.035) MWoA, whereas postcentral decreased 0.048). Furthermore, performed between-network (BNC) within-network across 17 networks, utilizing Yeo-17 atlas. Both HCs no BNC However, our that exhibited reduced FC dorsal attention (DAN) 0.031), differences all comparison HCs, alterations ASD, particularly thalamus, DAN Brain more susceptible

Language: Английский

Mechanotransduction in Development: A Focus on Angiogenesis DOI Creative Commons
Simona Alibrandi, Carmela Rinaldi, Sergio Lucio Vinci

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 346 - 346

Published: March 27, 2025

Cells respond to external mechanical cues and transduce these forces into biological signals. This process is known as mechanotransduction requires a group of proteins called mechanosensors. peculiar class receptors include extracellular matrix proteins, plasma membrane the cytoskeleton nuclear envelope. These cell components are responsive wide spectrum physical including stiffness, tensile force, hydrostatic pressure shear stress. Among mechanotransducers, Transient Receptor Potential (TRP) PIEZO family members mechanosensitive ion channels, coupling force transduction with intracellular cation transport. Their activity contributes embryo development, tissue remodeling repair, homeostasis. In particular, vessel development driven by hemodynamic such flow direction Perturbed involved in several pathological vascular phenotypes hereditary hemorrhagic telangiectasia. review conceived summarize most recent findings development. We first collected main features proteins. However, we focused on role during Mechanosensitive channels their function also discussed, focus brain morphogenesis.

Language: Английский

Citations

0
Effects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study DOI Creative Commons

Shuqing Wang,

Lin Ma, Song Wang

et al.

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 28, 2025

Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate effects sleep (ASD) on brain function migraine without aura (MWoA) via functional magnetic resonance imaging (fMRI). Twenty three MWoA and 23 healthy controls (HCs) were fairly included study. All participants underwent two MRI scans: one at baseline (prior deprivation) another following 24 h ASD. Images obtained blood-oxygen-level-dependent T1-weighted sequences a Siemens 7.0 T scanner. We conducted analyses changes low-frequency fluctuations (ALFF) values connectivity (FC) between networks within network before after ASD both group HC group. Additionally, we investigated relationship ALFF clinical features (VAS monthly days). In group, led significant increase left parahippocampal gyrus compared (p-FDR = 0.01). significantly greater 64 regions than baseline. most change detected right medial pulvinar thalamus 0.017), which showed negative correlation days. Moreover, seed-based (SBC) analysis using as seed point revealed increased cerebellar vermis (p-FWE 0.035) MWoA, whereas postcentral decreased 0.048). Furthermore, performed between-network (BNC) within-network across 17 networks, utilizing Yeo-17 atlas. Both HCs no BNC However, our that exhibited reduced FC dorsal attention (DAN) 0.031), differences all comparison HCs, alterations ASD, particularly thalamus, DAN Brain more susceptible

Language: Английский

Citations

0