Current Psychiatry Reports, Journal Year: 2022, Volume and Issue: 24(12), P. 777 - 788
Published: Nov. 22, 2022
Language: Английский
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2022, Volume and Issue: 8(7), P. 720 - 730
Published: Dec. 22, 2022
Anorexia nervosa (AN) is characterized by low body weight, disturbed eating, image disturbance, anxiety, and interoceptive dysfunction. However, the neural processes underlying these dysfunctions in AN are unclear. This investigation combined an pharmacological probe, peripheral β-adrenergic agonist isoproterenol, with resting-state functional magnetic resonance imaging to examine whether individuals relative healthy comparison participants show dysregulated coupling central autonomic network brain regions. Resting-state was performed 23 weight-restored female age- mass index–matched before after receiving isoproterenol infusions. Whole-brain connectivity (FC) changes were examined using seeds amygdala, anterior insular cortex, posterior cingulate ventromedial prefrontal cortex performing physiological noise correction procedures. Relative participants, adrenergic stimulation caused widespread FC reductions group between regions motor, premotor, frontal, parietal, visual Across both groups, inversely associated trait anxiety (State-Trait Anxiety Inventory-Trait), depression (9-item Patient Health Questionnaire), negative perception (Body Shape Questionnaire) measures, but not resting heart rate. These results accounted for baseline differences. Weight-restored females a state-dependent disruption of signaling autonomic, frontoparietal, sensorimotor networks that facilitate representation visceromotor regulation. Additionally, associations other suggest dysfunctional processing may contribute affective disturbance AN.
Language: Английский
Citations
11
Biological Psychology, Journal Year: 2024, Volume and Issue: 192, P. 108851 - 108851
Published: July 26, 2024
Language: Английский
Citations
2
Journal of Eating Disorders, Journal Year: 2023, Volume and Issue: 11(1)
Published: Oct. 23, 2023
This proof-of-concept study explores the role of aberrant interoception as a possible mechanism underlying restrictive eating symptoms in avoidant/restrictive food intake disorder (ARFID) compared to anorexia nervosa (AN) and healthy comparisons (HC).We report preliminary normative adolescent interoceptive data HCs (n = 100) adolescents with ARFID 30) AN (N 23). Adolescents (12-18) participated one-time virtual visit assess heartrate guessing accuracy (interoceptive accuracy), correlation between confidence guess awareness), self-reported sensibility).HC had comparable outcomes relative published adult norms, consistent existing literature. Data suggest that have poor heartbeat experience challenges deciphering signals, possibly contributing symptoms. While greater accuracy, they cite difficulty trusting body cues, perhaps their lack cue detection.Preliminary results reflect differences three groups.In this study, we wanted understand how individuals disorders, like (AN), sense respond different signals body, such heartbeat. process is called interoception. Difficulty sensing can lead various mental health disorders. We asked participants without an while wearing finger pulse oximeter, track (or accurate guesses were). also measured overall metacognitive awareness ability accurately interpret signals. Our replicate findings teenagers. For teens those listening bodies, but good accuracy. Teens better were more unsure about signaling. Overall, our initial disorders sense, interpret, might help explain habits. More research needed area.
Language: Английский
Citations
5
Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 148, P. 105122 - 105122
Published: March 11, 2023
Language: Английский
Citations
5
Current Psychiatry Reports, Journal Year: 2022, Volume and Issue: 24(12), P. 777 - 788
Published: Nov. 22, 2022
Language: Английский
Citations
8