Involvement of CB1R and CB2R Ligands in Sleep Disorders and Addictive Behaviors in the Last 25 Years DOI Creative Commons
Marcel Pérez-Morales, Rodolfo Espinoza-Abad, Fabio Garcı́a-Garcı́a

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 266 - 266

Published: Feb. 18, 2025

Over the last three decades, decriminalization and legalization of therapeutic recreational marijuana consumption have increased. Consequently, availability marijuana-based products associated with its use has These developments stimulated research on cannabinoids involving a wide range animal models clinical trials. Also, it is reported that promote sleep in naïve human participants, they seem to improve insomnia apnea patients. However, evidence from rigorous trials needed. In addition, among several physiological processes, cannabinoid receptors modulate dopamine synthesis release. this regard, side effects derivatives must not be ignored. The chronic could reduce responsivity, increase negative emotionality, induce anhedonia. Research neurobiological changes ligands models, regard both compounds, effectiveness outcomes guaranteed. review, we include detailed description mechanisms action brain their impact disorders addictive behaviors emphasize need understand potential risks benefits use. Evidence basic papers published between 2000 2024 are included. pharmacodynamics these compounds discussed terms sleep-wake regulation, drug addiction, behaviors.

Language: Английский

Involvement of CB1R and CB2R Ligands in Sleep Disorders and Addictive Behaviors in the Last 25 Years DOI Creative Commons
Marcel Pérez-Morales, Rodolfo Espinoza-Abad, Fabio Garcı́a-Garcı́a

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 266 - 266

Published: Feb. 18, 2025

Over the last three decades, decriminalization and legalization of therapeutic recreational marijuana consumption have increased. Consequently, availability marijuana-based products associated with its use has These developments stimulated research on cannabinoids involving a wide range animal models clinical trials. Also, it is reported that promote sleep in naïve human participants, they seem to improve insomnia apnea patients. However, evidence from rigorous trials needed. In addition, among several physiological processes, cannabinoid receptors modulate dopamine synthesis release. this regard, side effects derivatives must not be ignored. The chronic could reduce responsivity, increase negative emotionality, induce anhedonia. Research neurobiological changes ligands models, regard both compounds, effectiveness outcomes guaranteed. review, we include detailed description mechanisms action brain their impact disorders addictive behaviors emphasize need understand potential risks benefits use. Evidence basic papers published between 2000 2024 are included. pharmacodynamics these compounds discussed terms sleep-wake regulation, drug addiction, behaviors.

Language: Английский

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