Epidemiology and Impact of Disorders of Gut–Brain Interaction in Multiethnic Malaysia: An In‐Depth Analysis of Local Data From the Rome Foundation Global Epidemiology Study

Journal of Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Previous epidemiology studies from Malaysia on disorders of gut-brain interaction (DGBI) have utilized variable criteria. Furthermore, the impact DGBI quality life (QoL), healthcare utilization, diet, work productivity, and sleep in a multiethnic Asian setting like remains underexplored. Here, we aimed to determine among Malaysians based Rome IV 2072 Malaysian participants Foundation Global Epidemiology Study (RFGES) with complete data were included in-depth analysis. We assessed prevalence diagnoses, psychological distress, QoL, dietary patterns, sleep, activity impairment. The overall any was 19.3% (95% CI 17.6%-21.0%). top three most prevalent diagnoses functional constipation (5.1%; 95% 4.2%-6.1%), dyspepsia (3.4%; 2.7%-4.3%), diarrhea (1.6%; 1.1%-2.2%). Participants reported higher levels distress (somatization, anxiety, depression), significantly change (low FODMAPs but Mediterranean-based diet probiotics). there greater daytime sleepiness proportions presenteeism, impairment, impairment individuals DGBI. disease burden is significant Malaysia, increased change, sleepiness,

Language: Английский

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Back to Roots: Dysbiosis, Obesity, Metabolic Syndrome, Type 2 Diabetes Mellitus, and Obstructive Sleep Apnea—Is There an Objective Connection? A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4057 - 4057

Published: Nov. 26, 2024

In recent decades, it has become clear that the gut is more than just a digestive organ; also functions as an immune organ with regulatory capabilities and acts “second brain” influences brain function due to presence roles of microbiota (GM). The GM crucial component its host significantly impacts human health. Dysbiosis, or microbial imbalance, been closely linked various diseases, including gastrointestinal, neurological, psychiatric, metabolic disorders. aim this narrative review highlight in maintaining Sleep vital biological necessity, living organisms having evolved internal sleep–wake rhythm aligns roughly 24 h light/dark cycle, known circadian rhythm. This cycle essential for tissue repair, restoration, overall optimal body functioning. irregularities have prevalent modern society, fast-paced lifestyles often disrupting normal sleep patterns. Urban factors, such fast food consumption, shift work, exposure artificial light nighttime noise, medications, social activities, can adversely affect rhythms, dysbiosis being one many factors incriminated etiology

Language: Английский

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BioMapAI: Artificial Intelligence Multi-Omics Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Chronic diseases like ME/CFS and long COVID exhibit high heterogeneity with multifactorial etiology progression, complicating diagnosis treatment. To address this, we developed BioMapAI, an explainable Deep Learning framework using the richest longitudinal multi-'omics dataset for to date. This includes gut metagenomics, plasma metabolome, immune profiling, blood labs, clinical symptoms. By connecting asymptom matrix, BioMapAI identified both disease- symptom-specific biomarkers, reconstructed symptoms, achieved state-of-the-art precision in disease classification. We also created first connectivity map of these 'omics healthy states revealed how microbiome-immune-metabolome crosstalk shifted from ME/CFS. Thus, proposed several innovative mechanistic hypotheses ME/CFS: Disrupted microbial functions - SCFA (butyrate), BCAA (amino acid), tryptophan, benzoate lost connection lipids bile acids, activated inflammatory mucosal cells (MAIT, γδT cells) INFγ GzA secretion. These abnormal dynamics are linked key including gastrointestinal issues, fatigue, sleep problems.

Language: Английский

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The Bidirectional Relationship Between Sleep Disturbance and Functional Dyspepsia: A Systematic Review to Understand Mechanisms and Implications on Management

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Functional dyspepsia (FD) is a prevalent chronic digestive disorder that significantly impacts patients' quality of life. Sleep disturbance (SD) common among FD patients, yet the relationship between SD and remains poorly characterized. This systematic review explores bidirectional SD, investigating underlying mechanisms implications for management. A rigorous comprehensive search was conducted across PubMed, PubMed Central (PMC), Google Scholar, Cochrane Library, ScienceDirect using select keywords related to FD. Only studies published in English from past 10 years met inclusion exclusion criteria were included. Quality assessment tools specific study types employed minimize bias. After applying assessments, encompassed 30 studies. The key findings reveal frequently associated with significant proportion patients reporting poor sleep quality. linking are complex, involving circadian rhythm, visceral hypersensitivity, immune responses, psychological factors. Nonpharmacological treatments like cognitive behavioral therapy (CBT), acupuncture, pharmacological neuromodulators have shown promise managing offering hope improved patient outcomes. share relationship, influenced by complex interplay physiological, psychological, lifestyle Addressing may improve overall symptom Further research crucial, as it should focus on isolating causes their direct other functional gastrointestinal disorders (FGIDs), opening up new avenues understanding treatment.

Language: Английский

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