Association between SARS-CoV-2 Seropositivity and Severity of Out-of-Hospital Acute Ischemic Stroke Following Asymptomatic/Mild COVID-19 in Children DOI
Elsayed Abdelkreem, Ekram Mahmoud,

Nesma Mohamed

et al.

Journal of Pediatric Infectious Diseases, Journal Year: 2023, Volume and Issue: 19(01), P. 028 - 038

Published: Dec. 11, 2023

Abstract Objective This article investigates the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity and its association with severity new-onset ischemic stroke (AIS) among previously healthy children asymptomatic/mild disease 2019 (COVID-19). Methods A case–control study that included < 18 years out-of-hospital AIS undetermined etiology a control group children. Exclusion criteria were current symptoms, previous COVID-19 diagnosis, prior vaccination, active SARS-CoV-2 infection, history hospital admission in last 6 months, having predisposition. We screened for immunoglobulin G antibodies using enzyme-linked immunosorbent assay. The was evaluated Pediatric National Institutes Health Stroke Scale (PedNIHSS). Results 25 (15 males 10 females; median age 24 months) controls (11 14 months). detected 15 (60%) 11 (44%) (p = 0.258). Compared seronegative children, those seropositive had higher PedNIHSS scores (median 19 vs. 8.5; p 0.001), pediatric intensive care unit (93.3% 40%; 0.007), need mechanical ventilation (53.3% 10%; 0.040), D-dimer levels 3.5 1.75 μg/mL; 0.001). Conclusion may be associated more affecting during postacute phase asymptomatic/mildly symptomatic COVID-19.

Language: Английский

Thrombotic complications in children with Coronavirus disease 2019 and Multisystem Inflammatory Syndrome of Childhood DOI Creative Commons
Riten Kumar, Michael J. Rivkin, Leslie Raffini

et al.

Journal of Thrombosis and Haemostasis, Journal Year: 2023, Volume and Issue: 21(9), P. 2313 - 2326

Published: June 1, 2023

Language: Английский

Citations

14
Clinical decision support to enhance venous thromboembolism pharmacoprophylaxis prescribing for pediatric inpatients with COVID‐19 DOI
Adam Paul Yan, Chase Parsons,

Gregory H. Caplan

et al.

Pediatric Blood & Cancer, Journal Year: 2024, Volume and Issue: 71(3)

Published: Jan. 3, 2024

Abstract Objective To design and evaluate a clinical decision support (CDS) module to improve guideline concordant venous thromboembolism (VTE) pharmacoprophylaxis prescribing for pediatric inpatients with COVID‐19. Materials methods The proportion of patients who met our institutional practice guideline's (CPG) criteria VTE prophylaxis was compared those triggered CDS alert, indicating the patient needed prophylaxis, were prescribed pre post launch new prescribing. sensitivity, specificity, positive predictive value (PPV), negative value, F1‐score accuracy tool calculated pre‐ post‐intervention periods using CPG recommendation as gold standard. Accuracy defined sum true positives negatives over positives, false negatives, negatives. Logistic regression used identify variables associated correct thromboprophylaxis Results A significant increase in triggering alert occurred period (44.3% vs. 6.9%, p < .001); however, no reciprocal achieved (36.6% 40.9%, = .53). updated had an improved sensitivity (55.0% 13.3%), NPV (44.9% 36.3%), (66.7% 23.5%), (62.5% 42.0%), but inferior specificity (78.6% 100%) PPV (84.6% 100%). Discussion model overall performance correctly identifying requiring prophylaxis. Despite identification by module, receiving appropriate pharmacologic did not change. Conclusion tools need ongoing refinement validation maximize utility.

Language: Английский

Citations

2
Age and sex-specific stroke epidemiology in COVID-19 DOI Creative Commons
Youngran Kim, Maria A Parekh, Xiaojin Li

et al.

Frontiers in Stroke, Journal Year: 2023, Volume and Issue: 2

Published: June 7, 2023

Background COVID-19 has emerged as an independent risk factor for stroke. We aimed to determine age and sex-specific stroke incidence factors with in the US using a large electronic health record (EHR) that included both inpatients outpatients. Methods A retrospective cohort study was conducted individual-level data from Optum ® de-identified EHR. total of 387,330 individuals aged ≥ 18 laboratory-confirmed between March 1, 2020 December 31, were included. The primary outcome cumulative after confirmation within 180 days follow-up or until death. Kaplan–Meier curves acute ischemic (AIS), intracerebral hemorrhage (ICH), composite all strokes stratified by sex age, differences assessed log-rank test. relative demographics estimated multivariable Cox-proportional hazards regressions adjusted hazard ratios (aHRs). Results Of patients, 2,752 patients (0.71%, 95% CI 0.68–0.74) developed during 180-day follow-up, AIS 0.65% (95% 0.62–0.67), ICH 0.11% 0.10–0.12). among 57% occurred 3 days. Advanced associated substantially higher risk, aHR 6.92 (5.72–8.38) ages 65–74, 9.42 (7.74–11.47) 75–84, 11.35 (9.20–14.00) 85 older compared 18–44 years. Men had 32% women. African-American [aHR 1.78 (1.61–1.97)] Hispanic 1.48 (1.30–1.69)] increased white patients. Conclusion This several important findings. is highest first positivity; this decreases time. (both inpatient outpatient) follow-up. Traditional increase COVID-19. Male across groups. have

Language: Английский

Citations

4
COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage DOI Creative Commons
Daniela Renedo, Audrey C. Leasure, Rebecca Young

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(3)

Published: Jan. 31, 2024

Patients with ischemic stroke and concomitant COVID-19 infection have worse outcomes than those without this infection, but the impact of on hemorrhagic remains unclear. We aimed to assess if worsens in intracerebral hemorrhage (ICH).

Language: Английский

Citations

1
Postrecovery COVID-19 and interlinking diabetes and cardiovascular events DOI
Giuseppe Seghieri

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 377 - 382

Published: Jan. 1, 2024

Language: Английский

Citations

0
Stroke risks in patients with COVID-19: multiple mechanisms of SARS-CoV-2, impact of sex and age, vaccination, and long-term infection DOI Creative Commons
Moawiah M. Naffaa,

Ola A. Al-Ewaidat

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Sept. 20, 2024

Language: Английский

Citations

0
Trends in the Diagnosis of Pediatric Venous Thromboembolism and Arterial Ischemic Stroke during the COVID-19 Pandemic: An Administrative Database Study DOI
Riten Kumar,

Nan Chen,

Laura L. Lehman

et al.

The Journal of Pediatrics, Journal Year: 2024, Volume and Issue: unknown, P. 114328 - 114328

Published: Sept. 1, 2024

Language: Английский

Citations

0
COVID-19 Diagnosis, Oral Anticoagulation, and Stroke Risk in Patients with Atrial Fibrillation DOI
Lanting Yang, Shangbin Tang, Jingchuan Guo

et al.

American Journal of Cardiovascular Drugs, Journal Year: 2024, Volume and Issue: 24(5), P. 693 - 702

Published: Aug. 13, 2024

Language: Английский

Citations

0
Association between SARS-CoV-2 Seropositivity and Severity of Out-of-Hospital Acute Ischemic Stroke Following Asymptomatic/Mild COVID-19 in Children DOI
Elsayed Abdelkreem, Ekram Mahmoud,

Nesma Mohamed

et al.

Journal of Pediatric Infectious Diseases, Journal Year: 2023, Volume and Issue: 19(01), P. 028 - 038

Published: Dec. 11, 2023

Abstract Objective This article investigates the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity and its association with severity new-onset ischemic stroke (AIS) among previously healthy children asymptomatic/mild disease 2019 (COVID-19). Methods A case–control study that included < 18 years out-of-hospital AIS undetermined etiology a control group children. Exclusion criteria were current symptoms, previous COVID-19 diagnosis, prior vaccination, active SARS-CoV-2 infection, history hospital admission in last 6 months, having predisposition. We screened for immunoglobulin G antibodies using enzyme-linked immunosorbent assay. The was evaluated Pediatric National Institutes Health Stroke Scale (PedNIHSS). Results 25 (15 males 10 females; median age 24 months) controls (11 14 months). detected 15 (60%) 11 (44%) (p = 0.258). Compared seronegative children, those seropositive had higher PedNIHSS scores (median 19 vs. 8.5; p 0.001), pediatric intensive care unit (93.3% 40%; 0.007), need mechanical ventilation (53.3% 10%; 0.040), D-dimer levels 3.5 1.75 μg/mL; 0.001). Conclusion may be associated more affecting during postacute phase asymptomatic/mildly symptomatic COVID-19.

Language: Английский

Citations

0