Altered gut microbiota and systemic immunity in Chinese patients with schizophrenia comorbid with metabolic syndrome

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 5, 2024

Metabolic syndrome (MetS) is highly prevalent in individuals with schizophrenia (SZ), leading to negative consequences like premature mortality. Gut dysbiosis, which refers an imbalance of the microbiota, and chronic inflammation are associated both SZ MetS. However, relationship between gut host immunological dysfunction, comorbid MetS (SZ-MetS) remains unclear. This study aims explore alterations microbiota their correlation immune dysfunction SZ-MetS, offering new insights into its pathogenesis.

Language: Английский

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The synergistic effect of Levilactobacillus brevis IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 5, 2023

Owing to the emergence and spread of multidrug resistance mechanisms in Helicobacter pylori, achieving a successful eradication has become exceedingly difficult. Thus, this study for first time determines effect combination vitamin D3 probiotic on pathogenesis treatment H. pylori. We established an vitro experimental system using AGS human gastric carcinoma cells explored synergistic Levilactobacillus brevis IBRC-M10790 Live pasteurized L. brevis, brevis-derived membrane vesicles (MVs), cell-free supernatant (CFS), as well their with were used during study. assessed anti-inflammatory anti-oxidative effects these combinations RT-qPCR ELISA, respectively. further performed adhesion assay evaluate influence adherence rate pylori cells. Our results demonstrated that possess against infection The strain (particularly live its CFS) can more efficiently reduce expression pro-inflammatory cytokines IL-6, IL-8, IFN-γ, TNF-α Moreover, exhibited additive impact preserving integrity epithelial barrier by increasing tight junction protein ZO-1. Furthermore, potentially This indicates advantage combining attenuate pylori-induced inflammation oxidative stress. Consequently, co-supplementation be considered novel therapeutic approach manage prevent infection.

Language: Английский

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Are probiotics effective in reducing the metabolic side effects of psychiatric medication? A scoping review of evidence from clinical studies

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 15, 2024

Abstract The psychopharmacological treatment of patients with schizophrenia or depression is often accompanied by serious side effects. In particular, the clinical findings weight gain are worrying, as this effect can lead to various medical sequelae in future. However, metabolic changes psychiatric neglected unsuccessful. An improved knowledge possible therapeutic approaches needed. aim study was provide an overview utilisation and effectiveness probiotics reducing severe mental illness. A scoping review studies published until 15 June 2022 conducted identify using people depression. We systematically searched databases EMBASE, PubMed (MEDLINE), Web Science SCOPUS a predefined search string. addition, reference lists relevant publications were examined for additional studies. assessed two reviewers. primary outcomes weight-related measurements. secondary blood parameters gut microbiota. Four ultimately met inclusion criteria. Two which administered did not find significant effects on pharmacologically induced gain. other synbiotics (a combination prebiotics). Interestingly, less observed individuals combined intervention. Adjustments diet be helpful generally well-accepted interventions fight against use prebiotics (or synbiotics) dietary may represent promising strategy regard. few available showed no clear conclusions.

Language: Английский

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Impact of Probiotic Treatment on Clinical Symptom Reduction in Schizophrenia: A Systematic Review and Meta-Analysis

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 182, P. 413 - 420

Published: Jan. 24, 2025

Language: Английский

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Dysbiosis is associated with the behavioral phenotype observed in the triple-hit Wisket rat model of schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111276 - 111276

Published: Jan. 1, 2025

Language: Английский

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Psychobiotics and the gut-brain axis: advances in metabolite quantification and their implications for mental health

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Feb. 5, 2025

Psychobiotics are live microorganisms that, when administered in adequate amounts, confer mental health benefits to the host. Several clinical studies have demonstrated significant from psychobiotic administration, making them an emerging topic food science. Certain strains of Lactobacillus, Bifidobacterium, Streptococcus, Escherichia, and Enterococcus species known for their ability modulate gut-brain axis provide benefits. Proposed action mechanisms include production neuroactive compounds or precursors, which may cross blood-brain barrier, transported by extracellular vesicles. However, there is a lack vivo evidence directly confirming these mechanisms, although indirect recent suggest potential pathways further investigation. To advance our understanding, it crucial study within host, with accurate quantification and/or precursors being key such studies. Current methods, however, face challenges, as low sensitivity detecting trace metabolites limited specificity due interference other compounds, impacting reliability measurements. This review discusses field psychobiotics, compound estimation techniques, perspectives improvement quantifying

Language: Английский

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Nutrition and brain health: Implications of Mediterranean diet elements for psychiatric disorders

Schizophrenia Research, Journal Year: 2025, Volume and Issue: 281, P. 30 - 44

Published: May 1, 2025

Language: Английский

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Nutraceuticals and phytoceuticals in the treatment of schizophrenia: a systematic review and network meta-analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Sub-optimal response in schizophrenia is frequent, warranting augmentation strategies over treatment-as-usual (TAU).

Language: Английский

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The microbiome, guard or threat to infant health

Trends in Molecular Medicine, Journal Year: 2021, Volume and Issue: 27(12), P. 1175 - 1186

Published: Sept. 10, 2021

Language: Английский

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Genetic association between circulating selenium level and the risk of schizophrenia in the European population: A two-sample Mendelian randomization study

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 23, 2022

The association between circulating the selenium level and risk of schizophrenia remains unclear.To determine relationship schizophrenia, using Mendelian Randomization method in European population.Single nucleotide polymorphisms (SNPs) associated with were identified at p < 5 × 10-8. inverse variance weighted (IVW) was used as principal MR analysis, Egger, median, PRESSO to accuracy IVW results. Cochran's Q-test Leave-One-Out sensitivity analysis performed evaluate heterogeneity stability genetic variants on schizophrenia.The decreased by (OR: 0.906, 95% CI:0.867-0.947). methods got similar No detected Q-test, no single SNP driving overall effect leave-one-out analysis.Our study provides support for schizophrenia; an elevated schizophrenia.

Language: Английский

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