The independent and interactive effects of heavy metal pollution and vitamin D deficiency on early kidney injury indicators: analysis of the National Health and Nutrition Examination Survey 2001–2004 DOI Creative Commons
Suoshi Jing,

Yuan Ge,

Jingju Pan

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Heavy metals (e.g., cadmium, lead, mercury, etc.) can infiltrate the human body via diverse routes, with a propensity to accumulate in kidney cortex, thereby precipitating dysfunction. Vitamin D has been implicated mitigating oxidative stress and inflammatory reactions triggered by heavy metal exposure. However, interplay between toxicity vitamin deficiency context of incipient injury remains an underexplored area research. Utilizing data from National Health Nutrition Examination Survey spanning 2001 2004, Our methodology leveraged spline smoothing within framework generalized additive models more vividly elucidate impact exposure serum levels on trajectory early biomarkers (including albumin-to-creatinine ratio, β-2 microglobulin (B2M), cystatin C (CYST), estimated glomerular filtration rate (eGFR) (serum creatinine(SCr)-based(eGFR), CYST-based eGFR, SCr-CYST-based eGFR). Furthermore, we conducted interaction analysis assess combined effects injury. The cohort comprised 2,422 adults. results indicated that cadmium were positively correlated B2M, CYST, negatively eGFRc, eGFRs. Similarly, lead showed positive correlation ACR, negative eGFRc&s. In contrast, mercury CYST eGFRc. addition, there was indicators (P for interaction: B2M: 0.028, CYST: 0.038, eGFRc&s: 0.011). This study suggests increased risk It highlights potential importance targeted supplementation reduction these findings warrant validation through further prospective

Language: Английский

The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis DOI
Ruonan Wang, Yuxiang Huang, Lu Yu

et al.

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 374, P. 110424 - 110424

Published: Feb. 26, 2023

Language: Английский

Citations

13
Curcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2 DOI Open Access
Huiyan Deng, Miaojian Wan, Huaping Li

et al.

Bioengineered, Journal Year: 2021, Volume and Issue: 12(2), P. 9993 - 10006

Published: Oct. 21, 2021

Curcumin suppressed ultraviolet (UV) induced skin carcinogenesis and activated the nuclear factor erythroid 2-related 2 (Nrf2) pathway. However, whether curcumin protects injury caused by UV is still unknown. A vitro model was established effects on Hacat cells were detected. Nrf2 knocked down in to verify role protective effect of curcumin. Results indicated that (UVA) (or B (UVB)) irradiation would lead decreased cell proliferation, increased apoptosis, catalase, heme oxygenase 1, superoxide dismutase expression, levels protein carbonylation malondialdehyde (p < 0.05). These adverse events could be reversed adding 5-μM Meanwhile, we found application effectively accumulation cells. While knockdown cells, against UVA UVB) attenuated. Conclusively, exposure-induced photo-damage regulating expression.

Language: Английский

Citations

30
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway DOI Creative Commons
Feiyan Yang, Xudong He, Tao Chen

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Food-derived bioactive peptides are considered as the important sources of natural ingredients. Approximately 3094 were identified by nESI-LC-MS/MS in hydrolyzed yak milk residue. Peptide KALNEINQF (T10) is strongest antioxidant peptide. The damage model H2O2-induced human umbilical vein endothelial cells (HUVECs) was used to evaluate effect. After treatment with 25, 50, or 100 μg/mL T10 peptide, obviously decreased and increased cell survival. Comparing group, superoxide dismutase (SOD) activities significantly 1.03, 1.1, 1.33 times, glutathione reductase (GR) 1.11, 1.30, 1.43 respectively. Malondialdehyde (MDA) also reduced 1.41, 1.54, 1.72 inhibited apoptosis HUVECs, protein expressions apoptosis-related genes bcl-2 bax 1.95 1.44 respectively, suggesting decreases mitochondria-dependent pathway. RNA Nrf2, HO-1, NQO1 2.00, 2.11, 1.94 times; p-Nrf2, 2.67, 1.73, 1.04 Keap1 downregulated 3.9 1.32 regulated Nrf2 pathway related (Keap1, NQO1), blocking protective effect T10. Taken together, peptide isolated from residue has a against HUVECs molecular mechanisms involved regulation signaling apoptosis.

Language: Английский

Citations

28
HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling DOI Creative Commons
Lucyna Kozłowska, Susana Viegas, Paul T.J. Scheepers

et al.

Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109281 - 109281

Published: Jan. 16, 2025

E-waste contains hazardous chemicals that may be a direct health risk for workers involved in recycling. We conducted an untargeted metabolomics analysis of urine samples collected from male e-waste processing to explore metabolic changes associated with chemical exposures recycling Belgium, Finland, Latvia, Luxembourg, the Netherlands, Poland, and Portugal. Questionnaire data were obtained (sorting, dismantling, shredding, pre-processing, metal, non-metal processing), as well controls no known occupational exposure. Pre- post-shift analysed using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS). A total 32 endogenous urinary metabolites annotated Variable Importance Projection (VIP) above 2, indicating is mainly steroid hormone neurotransmitter metabolism, energy bile acid biosynthesis, inflammation. The highest VIP was observed dopamine-o-quinone, which linked Parkinson's disease. These other metabolism employed need further verification targeted studies.

Language: Английский

Citations

0
The independent and interactive effects of heavy metal pollution and vitamin D deficiency on early kidney injury indicators: analysis of the National Health and Nutrition Examination Survey 2001–2004 DOI Creative Commons
Suoshi Jing,

Yuan Ge,

Jingju Pan

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Heavy metals (e.g., cadmium, lead, mercury, etc.) can infiltrate the human body via diverse routes, with a propensity to accumulate in kidney cortex, thereby precipitating dysfunction. Vitamin D has been implicated mitigating oxidative stress and inflammatory reactions triggered by heavy metal exposure. However, interplay between toxicity vitamin deficiency context of incipient injury remains an underexplored area research. Utilizing data from National Health Nutrition Examination Survey spanning 2001 2004, Our methodology leveraged spline smoothing within framework generalized additive models more vividly elucidate impact exposure serum levels on trajectory early biomarkers (including albumin-to-creatinine ratio, β-2 microglobulin (B2M), cystatin C (CYST), estimated glomerular filtration rate (eGFR) (serum creatinine(SCr)-based(eGFR), CYST-based eGFR, SCr-CYST-based eGFR). Furthermore, we conducted interaction analysis assess combined effects injury. The cohort comprised 2,422 adults. results indicated that cadmium were positively correlated B2M, CYST, negatively eGFRc, eGFRs. Similarly, lead showed positive correlation ACR, negative eGFRc&s. In contrast, mercury CYST eGFRc. addition, there was indicators (P for interaction: B2M: 0.028, CYST: 0.038, eGFRc&s: 0.011). This study suggests increased risk It highlights potential importance targeted supplementation reduction these findings warrant validation through further prospective

Language: Английский

Citations

0