Evolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameters

Metabolites, Journal Year: 2023, Volume and Issue: 13(8), P. 931 - 931

Published: Aug. 9, 2023

The inflammatory reaction and pathogenesis of COVID-19 may be modulated by circulating trace elements (Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn)) Metallothioneins (MTs). Thus, the present study aimed to investigate their relationship with clinical, biochemical, parameters in patients at early Intensive Care Unit (ICU) phase. Critically ill (n = 86) were monitored from first day ICU admission until third stay. Serum samples used assess mineral levels via Inductively Coupled Plasma Mass Spectrometry (ICP-MS) MT differential pulse voltammetry. Levels Cu MTs significantly decreased after 3 days (p < 0.05), increasing prevalence Cu-deficient values 50% 65.3% 0.015). Fe Zn shown have a predictive value for mortality severity. suggests element deficiency risk factor during treatment COVID-19, as it is related different biochemical clinical parameters, indicating possible beneficial effect restoring proper these micronutrients.

Language: Английский

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Sensitive Marker Affected by All Systemic Abnormalities—troponine

Eurasian Journal of Medicine, Journal Year: 2023, Volume and Issue: 54(Supp1), P. S43 - S46

Published: Jan. 18, 2023

Whether due to myocardial infarction or not, we find troponin levels be high when damage occurs. Elevated may not always a caused by plaque rupture on the basis of classically known coronary thrombosis. In this sense, types have been defined. review, aimed bring together conditions that directly indirectly affect myocardium, except for acute syndromes.

Language: Английский

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Investigation of supplement products preferred by healthcare professionals during COVID-19 pandemic process

Journal of Contemporary Medicine, Journal Year: 2023, Volume and Issue: 13(1), P. 107 - 113

Published: Jan. 31, 2023

Objective: Various products are used to strengthen immunity in prevention and treatment during the COVID-19 pandemic affecting whole world, which has no cure yet, vaccine just been used. This study was planned learn about supplements by healthcare professionals. Methods: A questionnaire applied physicians, nurses, technicians, secretaries, staff working operating room, intensive care, ward, outpatient clinic e-mail, WhatsApp, or face-to-face interview method. Results: There difference between groups terms of being COVID-19-positive. The most were primarily Mg vitamin D, C, ginger, Zn, turmeric, green tea, complex, thyme, black elderberry (sambucus nigra), propolis, prebiotic/probiotic, acetylsalicylic acid (ASA), cumin (niger sativa), N-acetyl cysteine (NAC), selenium (Se), Coenzyme-Q10, cinnamon, glutathione (GSH) quercetin respectively. No one had alpha lipoic (ALA). that showed significant differences with without propolis ASA. Conclusıon: Since it is not asked when product used, although possible evaluate its effectiveness for preventive therapeutic purposes, known be natural, inexpensive, easily accessible antiviral may preferred.

Language: Английский

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Essential Trace Element Levels in Patients with Cutaneous Anthrax

Eastern Journal Of Medicine, Journal Year: 2023, Volume and Issue: 28(2), P. 272 - 278

Published: Jan. 1, 2023

The causative microorganism in anthrax is Bacillus anthracis and this disease more common some regions of Türkiye.Changes trace elements other than iron infection have not been studied.In study, iron, copper, lead, zi nc, manganese, magnesium, cadmium cobalt levels were investigated cases with cutaneous anthrax.Fifteen patients 15 healthy individuals wereincluded the study.The groups similar to each terms age gender.Anthrax was diagnosed according contact status animals, symptoms, examination, microbiological results.We performed our study Atomic Absorption Spectrophotometer (UNICAM-929 spectrophotometer).Serum significantly higher control subjects (p<0.05).Serum zinc, lower (p<0.05).The copper/zinc molar ratio increased subjects.It has reported that cadmium, lead are low copper level high infectious diseases.But we determined opposite situation anthrax.As a result, it can be said detection cell suppresses immune system.Also, zinc used as marker for disease.

Language: Английский

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Staging classification of omicron variant SARS-CoV-2 infection based on dual-spectrometer LIBS (DS-LIBS) combined with machine learning

Optics Express, Journal Year: 2023, Volume and Issue: 31(25), P. 42413 - 42413

Published: Nov. 16, 2023

Effective differentiation of the infection stages omicron can provide significant assistance in transmission control and treatment strategies. The combination LIBS serum detection machine learning methods, as a novel disease auxiliary diagnostic approach, has high potential for rapid accurate staging classification Omicron infection. However, conventional single-spectrometer methods focus on detecting spectra major elements, while trace elements are more closely related to progression COVID-19. Here, we proposed analytical method with dual-spectrometer (DS-LIBS) assisted classify different omicron. DS-LIBS, including broadband spectrometer narrowband spectrometer, enables synchronous collection elemental serum, respectively. By employing RF models, accuracy using data collected from DS-LIBS reach 0.92, compared 0.84 0.73 when LIBS. This improvement highlights efficacy approach. Then, performance four SVM, RF, IGBT, ETree, is compared. ETree demonstrates best, cross-validation test set accuracies 0.94 0.93, Additionally, it achieves 1.00, 0.89 B1-acute, B1-post, B2, B3. Overall, results demonstrate that combined model effective

Language: Английский

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