Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 519 - 519

Published: July 12, 2024

Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.

Language: Английский

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New insights into brain injury in chickens induced by bisphenol A and selenium deficiency—Mitochondrial reactive oxygen species and mitophagy-apoptosis crosstalk homeostasis

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 166890 - 166890

Published: Sept. 7, 2023

Language: Английский

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Disruptive multiple cell death pathways of bisphenol-A

Toxicology Mechanisms and Methods, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 15, 2025

Endocrine-disrupting chemicals (EDCs) significantly contribute to health issues by interfering with hormonal functions. Bisphenol A (BPA), a prominent EDC, is extensively utilized as monomer and plasticizer in producing polycarbonate plastic epoxy resins, making it one of the highest-demanded commercial use. This major component used products, including bottles, containers, storage items, food serving ware. Exposure BPA happens through oral, respiratory, transdermal routes eye contact. As an disrupts binding, leading various problems, such cancers, reproductive abnormalities, metabolic syndrome, immune dysfunction, neurological effects, cardiovascular respiratory issues, obesity. mimics hormone estrogen but exhibits weak affinity for receptors. binding triggers multiple cell death pathways, necroptosis, pyroptosis, apoptosis, ferroptosis, autophagy, across different types. Numerous clinical, in-vitro, in-vivo experiments have demonstrated that exposure results unfavorable effects. review highlights mechanisms pathways initiated associated negative consequences. The extensive use its frequent detection environmental biological models underscore urgent need further investigation into effects development safe alternatives. Addressing risks posed involves comprehensive approach includes reducing finding novel substitutes lessen detrimental impact on humans.

Language: Английский

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The protection of bisphenol A-modulated miRNAs and targets by natural products

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109299 - 109299

Published: Jan. 1, 2025

Bisphenol A (BPA) is a ubiquitous environmental pollutant with endocrine-disrupting functions. Identifying protective drugs and exploring the mechanisms against BPA are crucial in healthcare. Natural products exhibiting antioxidant properties considered to be able protect toxicity. Although BPA-modulated targets miRNAs have been individually reported, their connections natural were rarely organized. With help of protein-protein interaction database (STRING), relationship between individual was interconnected provide systemic view. In this review, BPA-downregulated -upregulated classified, interactive network innovatively analyzed using bioinformatic (STRING). also retrieved ingeniously connected targets. Moreover, novel connection BPA-countering integrated into All these targets-associated and/or incorporated STRING network, providing relationships. Overall, target-miRNA-protecting product axis constructed, straightforward direction for effects products.

Language: Английский

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MicroRNA-21 plays a role in exacerbating chronic obstructive pulmonary disease by regulating necroptosis and apoptosis in bronchial epithelial cells

Tobacco Induced Diseases, Journal Year: 2025, Volume and Issue: 23(March), P. 1 - 9

Published: March 18, 2025

Bronchial epithelial cell damage is an important determinant of the severity chronic obstructive pulmonary (COPD). However, exact molecular mechanisms underlying this death in COPD development are not well understood. This study investigates involvement microRNA-21 (miR-21/miRNA-21) and its mechanism. A mouse model was created by exposing mice to cigarette smoke (CS) injecting them with extract (CSE). Both wild-type miR-21 knockout (miR-21-/-) were used investigate role (miR-21) exacerbating COPD. Various assays analyses performed, including HE staining, tunel enzyme-linked immunosorbent assay (ELISA), flow cytometry, quantitative real-time polymerase chain reaction (RT-qPCR), western blotting (WB) measure outcomes such as pathological morphological changes, necroptosis, apoptosis, levels inflammatory factors. Our results revealed upregulation lung tissue mice. Additionally, resulted decreased bronchial necroptosis evidenced downregulation tumor necrosis factor receptor 1 (TNFR1), phosphoryl-mixed lineage kinase domain-like protein (p-MLKL) caspase-3. apoptosis ultimately led a reduction factors damage-associated patterns (DAMPs), factor-α (TNF-α), interleukin-1β (IL- 1β), interleukin-6 (IL-6) high mobility group B1(HMGB1) lungs, thereby ameliorating findings suggest that contributes worsening disease modulating cells, providing new theoretical basis for pathogenesis disease.

Language: Английский

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The effects of bisphenol S exposure on the growth, physiological and biochemical indices, and ecdysteroid receptor gene expression in red swamp crayfish, Procambarus clarkii

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 276, P. 109811 - 109811

Published: Dec. 5, 2023

Language: Английский

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Ratlarda BPA ile Oluşturulan Böbrek Hasarında Ellajik Asit Uygulamasının DNA Hasarı ve Bazı Böbrek Fonksiyon Parametreleri Üzerine Etkisi

Deleted Journal, Journal Year: 2024, Volume and Issue: 8(1), P. 58 - 66

Published: April 28, 2024

Amaç: Bisfenoller (BP'ler), genel popülasyonun yaygın olarak kullandığı birçok üründe bulunan potansiyel hormon bozuculardır. Bisfenol A (BPA) ise, vücudun metabolik sistemleri üzerindeki olumsuz etkilerine rağmen, bazı plastik ve reçinelerin üretiminde uzun yıllardır kullanılan endüstriyel bir kimyasaldır. BPA gibi toksik ajanlardan dolayısıyla çevresel kirleticilerden etkilenen en önemli organlardan biri böbreklerdir. Ellajik asit (EA) fitokimyasal polifenol bileşiğidir yapılan çalışmada EA’nın antioksidan, anti-mutajenik, anti-kanser anti-apoptotik özellikler sergilediği rapor edilmektedir. Bu çalışmanın amacı ile indüklenen böbrek hasarı üzerine etkisini ortaya koymaktır. Gereç Yöntemler: 24 adet erkek rat, Kontrol, (30 gün süreyle 25mg/kg), EA 10 mg/kg) BPA+EA sırasıyla 25mg-10mg/kg) dört gruba ayrıldı (n=6). Çalışma sonunda dekapite edilen ratlardan alınan böbreklerin ağırlıkları kan serumundan üre nitrojeni (BUN) kreatinin değerleri ölçüldü. Bunun yanında histolojik görüntüsünü koymak amacıyla Pikro Sirius Red boyaması, dokularda meydana gelen DNA hasarının konulabilmesi 8-hidroksideoksiguanozin antikoru kullanılarak immunohistokimyasal boyama yapılmıştır. Bulgular: Yapılan değerlendirme sonucunda sol böbreğe ait mutlak nispi ağırlığın grubunda artış gösterdiği, ise kontrole yaklaşarak düştüğü gözlenmiştir. Kan azotu değerlerinde kontrol grubuna göre ciddi olduğu görülmüş, bu değerlerin azaldığı tespit edilmiştir. gruptan dokularında primer antikorunun glomerulus tubul yapılarında yoğun pozitif reaksiyon verdiği, yapısında dejenerasyon vakuolizasyon olduğu, bölgesel nekroz alanları bulunduğu yapılarının bozulduğu Buna karşın gruplarında birbirine benzer şekilde oldukça az alana rastlanmıştır. birlikte kullanıldığı grupta gerek yapısı BPA’nın tek başına düzelmeler görülürken 8- hidroksideoksiguanozin alanların Sonuç: Toplumun her kesiminden bireylerin maruz kalma ihtimali olan dokusuna vereceği muhtemel zararların, içeren gıda katkı maddeleri azaltılabileceği sonucuna varılmıştır.

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