This
study
aimed
to
evaluate
the
applicability
of
electrocoagulation
process
as
a
pretreatment
for
boron
mitigation
before
seawater
desalination
through
reverse
osmosis.
Batch
experiments
were
conducted
investigate
several
operational
parameters
on
removal
from
synthetic
and
real
seawater,
including
current
density,
electrolysis
time,
aluminum
dissolution,
initial
pH,
concentration,
presence
other
ions.
Increasing
intensity
initially
accelerates
dissolution
adsorption
boron,
but
beyond
certain
point
it
leads
rapid
formation
large
particles
ineffective
hydroxide
with
reduced
capacity
adsorb
boron.
Generally,
is
best
removed
(72%)
at
density
16.67
mA.cm-2,
time
90
min,
pHi
8,
content
5
mg.L-1.
Nevertheless,
application
has
been
challenging
due
complexity
matrix
competitive
ions
like
magnesium,
resulting
in
lower
deboronation
rates.
Regarding
EDS,
XRD,
FTIR
analysis,
confirmed
solid
samples
20
mA.cm-²
compared
mA.cm-²,
indicating
less
efficient
crystalline
boehmite.
Kinetic
studies
demonstrated
adherence
Lagergren's
pseudo-first-order
mechanism
adequacy
intraparticle
diffusion
model,
suggesting
transport
molecules
aqueous
phase
Al(OH)3
surface,
then
diffused
into
pores.
Finally,
remains
an
economical
sustainable
paving
way
high-quality
freshwater
production
water-scarce
regions.
Skin Research and Technology,
Journal Year:
2024,
Volume and Issue:
30(5)
Published: May 1, 2024
Abstract
Wound
healing
is
a
complex,
intricate,
and
dynamic
process
that
requires
effective
therapeutic
management.
The
current
study
evaluates
the
wound
potentials
of
methanolic
extract
Cuminum
cyminum
L.
seeds
(CCS)
in
rats.
Sprague
Dawley
(24)
rats
were
distributed
into
four
cages,
wounds
produced
on
back
neck,
received
two
daily
topical
treatments
for
14
days:
A,
normal
saline;
B,
wounded
treated
with
intrasite
gel;
C
D,
0.2
mL
250
500
mg/kg
CCS,
respectively.
After
that,
area
closure
percentage
evaluated,
tissues
dissected
histopathological,
immunohistochemical,
biochemical
examinations.
Acute
toxicity
trials
CCS
showed
absence
any
physiological
changes
or
mortality
application
caused
significant
reduction
size
statistically
elevated
contraction
than
those
vehicle
treatment
up‐regulation
collagen
fiber,
fibroblasts,
fewer
inflammatory
cells
(inflammation)
granulation
tissues.
TGF‐β1
(angiogenetic
factor)
was
significantly
more
expressed
CCS‐treated
comparison
to
saline‐treated
rats;
therefore,
fibroblasts
transformed
myofibroblasts
(angiogenesis).
remarkable
antioxidant
(higher
SOD
CAT
enzymes)
decreased
MDA
(lipid
peroxidation)
levels
their
tissue
homogenates.
Hydroxyproline
amino
acid
(collagen)
up‐regulated
by
treatment,
which
commonly
related
faster
area.
outcomes
suggest
as
viable
new
source
pharmaceuticals
treatment.
Skin Research and Technology,
Journal Year:
2024,
Volume and Issue:
30(8)
Published: Aug. 1, 2024
Abstract
Background
Dorema
aucheri
gum
(DAG)
is
a
bitter
flavonoid
widely
used
for
numerous
medicinal
purposes
including
wound
recovery.
The
present
work
investigates
the
acute
toxicity
and
wound‐healing
effects
of
DAG
in
excisional
skin
injury
rats.
Materials
methods
Sprague
Dawley
rats
(24)
were
clustered
into
four
groups,
each
rat
had
full‐thickness
dorsal
neck
(2.00
cm)
addressed
with
0.2
mL
following
treatments
15
days:
Group
A
(vehicle),
normal
saline;
B,
received
intrasite
gel;
C
D,
250
500
mg/kg
DAG,
respectively.
Results
results
revealed
absence
any
toxic
signs
who
oral
dosages
2
5
g/kg
DAG.
Wound
healing
was
significantly
accelerated
indicated
by
smaller
open
areas
higher
contraction
percentages
compared
to
vehicle
Histological
evaluation
fibroblast
formation,
collagen
deposition,
noticeably
lower
inflammatory
cell
infiltration
granulated
tissues
DAG‐addressed
treatment
caused
significant
modulation
immunohistochemical
proteins
(decreased
Bax
increased
HSP
70)
mediators
(reduced
TNF‐α,
IL‐6,
magnified
IL‐10),
which
varied
Moreover,
topical
led
upregulation
hydroxyproline
(HDX)
(collagen)
antioxidant
content.
At
same
time,
decreased
lipid
peroxidation
(MDA)
levels
healed
obtained
from
DAG‐treated
Conclusion
might
be
linked
modulatory
effect
its
phytochemicals
(polysaccharides,
flavonoids,
phenolic)
on
cellular
mechanisms,
justify
their
folkloric
use
provokes
further
investigation
as
therapeutic
drug
additives
contraction.
SAGE Open Medicine,
Journal Year:
2023,
Volume and Issue:
11
Published: Jan. 1, 2023
Pinostrobin
(5-hydroxy-7-methoxyflavanone;
PN)
is
a
natural
active
ingredient
with
numerous
biological
activities
extensively
utilized
in
tumour
chemotherapy.
The
present
study
investigates
the
chemo-preventive
potentials
of
PN
on
azoxymethane-mediated
colonic
aberrant
crypt
foci
rats.Sprague
Dawley
rats
clustered
into
five
groups,
normal
control
(A)
and
cancer
controls
were
subcutaneously
injected
saline
15
mg/kg
azoxymethane,
respectively,
nourished
10%
tween
20
fed
20;
reference
(C),
azoxymethane
(intraperitoneal)
35
5-fluorouracil
(5-FU);
D
E
rat
groups
received
subcutaneous
injection
30
60
PN,
respectively.The
acute
toxicity
trial
showed
lack
any
abnormal
signs
or
mortality
ingested
250
500
PN.
gross
morphology
colon
tissues
revealed
significantly
lower
total
incidence
PN-treated
than
that
controls.
Histological
examination
increased
availability
bizarrely
elongated
nuclei,
stratified
cells
higher
depletion
submucosal
glands
treatment
caused
positive
modulation
apoptotic
(Bax
Bcl-2)
proteins
inflammatory
cytokines
(TNF-α,
IL-6
IL-10).
Moreover,
had
antioxidants
(superoxide
dismutase)
malondialdehyde
concentrations
their
tissue
homogenates.The
chemoprotective
efficiency
against
azoxymethane-induced
shown
by
values
inhibition
percentage,
possibly
through
augmentation
genes
responsible
for
cascade
inflammations
originating
from
oxidative
stress
insults.
Baghdad Science Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 19, 2024
تم
استخدام
Ephedra
intermedia
كعلاج
تقليدي
لأغراض
صحية
مختلفة
بما
في
ذلك
اضطرابات
المعدة.
للتحقق
من
صحة
استخدامه
التقليدي،
قمنا
بدراسة
السمية
الحادة
والتأثيرات
الوقائية
المعدية
لمستخلص
أوراق
(EILE)
إصابة
المعدة
الناجمة
عن
الإيثانول
الفئران.
فصل
الفئران
سبراغ
داولي
بشكل
عشوائي
إلى
5
مجموعات:
مجموعة
السيطرة
الطبيعية
(A)
ومجموعة
المقرحة
(B)
تلقت
طريق
الفم
0.5
٪
كاربوكسي
ميثيل
السليلوز
(CMC)؛
(C)
التي
تناولت
أوميبرازول
20
ملغم/كغم؛
المجموعتين
D
وE،
250
و500
ملغم/كغم
EILE
على
التوالي.
بعد
60
دقيقة،
المجموعات
B-E
جرعة
فموية
المطلق
لاحداث
قرحة
وبعد
دقيقة
أخرى،
تخدير
والتضحية
بها.
أظهرت
تجربة
عدم
وجود
أي
علامات
سمية
الجرذان
المعرضة
لتناول
2
و5
غم
/
كغم
الفم.
وكشفت
الوقاية
اختراق
كبير
لأنسجة
القرحة،
كما
يتضح
انخفاض
محتوى
المخاط،
وانخفاض
درجة
الحموضة
المعدة،
واخداث
تمزقات
شديدة
الطبقة
المخاطية.
اظهرت
عولجت
بالأوميبرازول
أو
تأثيرا
قليلا
جدا
تلف
أنسجة
مما
يشير
تأثير
منخفض
ملحوظ
جروح
بوساطة
الإيثانول،
تحسن
مخاط
ودرجة
الحموضة،
وخفض
مساحات
الوذمة،
وتسرب
الكريات
البيض
تحت
جناسة
أدى
علاج
زيادة
كبيرة
إنزيمات
مضادات
الأكسدة
(SOD
وCAT)
MDA
ملحوظ.
علاوة
ذلك،
المعالجة
بـ
التعبير
صبغة
PAS
ظهارة
والغدد
القاعدية
(القاعدة
والرقبة
والبرزخ).
يمكن
أن
تعزى
التأثيرات
المعوية
لـ
زيادتها
الإيجابية
لعوامل
المختلفة،
قد
يؤكد
صحتها
كمضاف
علاجي
مستقبلي
لقرحة
التقييم
الدوائي.
Biological Trace Element Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Abstract
The
purpose
of
this
study
is
to
measure
the
effects
acrylamide
(AA)
on
bone
marrow
and
blood
protective
efficacy
boric
acid
(B)
in
rats.
animals
were
divided
into
five
groups:
control,
B,
low-dose
B
+
AA,
high-dose
AA.
After
15
th
day
experiment,
their
harvested
be
kept
for
hematological
analyses.
While
white
cells
(WBC)
increased
following
administration
bodyweight,
red
cells,
platelets,
hemoglobin,
hematocrit,
nucleated
cell
counts
significantly
decreased
number.
Conversely,
bodyweight
all
these
parameters
apart
from
WBC
AA
groups
when
compared
control.
However,
was
more
effective
than
preventing
AA-induced
damage.
present
suggests
that
treatment
could
help
protect
against
toxicity.
Graphical
Biological Trace Element Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 30, 2024
Medullary
thyroid
cancer
(MTC)
is
a
highly
aggressive
and
chemotherapy-resistant
originating
from
the
thyroid's
parafollicular
C
cells.
Due
to
its
resistance
conventional
treatments,
alternative
therapies
such
as
boric
acid
have
been
explored.
Boric
acid,
boron-based
compound,
has
shown
anticarcinogenic
effects,
positioning
it
potential
treatment
option
for
MTC.
TT
medullary
carcinoma
cell
line
(TT
cells)
human
fibroblast
(HThF
were
utilized
culture
experiments.
Cell
viability
was
assessed
using
2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide
(XTT)
assay.
Total
RNA
extracted
Trizol
reagent
gene
expression
microRNA
(miRNA)
analysis
via
reverse
transcription-polymerase
chain
reaction
(RT-PCR).
The
extent
of
apoptosis
induced
by
determined
terminal
deoxynucleotidyl
transferase
dUTP
nick
end
labeling
(TUNEL)
Colony
formation
assays
conducted
evaluate
impact
on
colony-forming
ability
MTC
At
48
h,
50%
inhibitory
concentration
(IC50)
found
be
35
μM.
Treatment
with
resulted
in
significant
modulation
apoptosis-related
genes
miRNAs,
including
increased
phorbol-12-myristate-13-acetate-induced
protein
1(NOXA),
apoptotic
protease
activating
factor
1
(APAF-1),
Bcl-2-associated
X
(Bax),
caspase-3,
caspase-9.
In
contrast,
B
lymphoma
2
(Bcl2),
lymphoma-
extra-large
(Bcl-xl),
microRNA-21
(miR-21),
which
are
linked
aggressiveness
MTC,
significantly
reduced.
TUNEL
assay
indicated
14%
rate,
there
67.9%
reduction
colony
formation,
Our
study
suggests
that
may
anticancer
activity
modulating
pathways.
These
findings
suggest
could
therapeutic
agent
possibly
other
malignancies
similar
pathogenic
mechanisms.
Bioorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
152, P. 107730 - 107730
Published: Aug. 16, 2024
Breast
cancer
is
the
most
prevalent
among
women
globally,
with
triple-negative
breast
(TNBC)
associated
poor
prognosis
and
low
five-year
survival
rates.
Schiff
base
compounds,
known
for
their
extensive
pharmacological
activities,
have
garnered
significant
attention
in
drug
research.
This
study
aimed
to
evaluate
anticancer
potential
of
a
novel
β-diiminato
compound
elucidate
its
mechanism
action.
The
compound's
effect
on
cell
viability
was
assessed
using
MTT
assays
lines
including
MCF-7
MDA-MB-231.
Cytotoxic
effects
were
further
analyzed
trypan
blue
exclusion
lactate
dehydrogenase
(LDH)
release
assays.
In
order
assess
inhibitory
activity
mode
death
induced
by
this
compound,
flow
cytometry
cycle
distribution
apoptosis
analysis
carried
out.
Apoptosis
incidence
initially
through
nuclear
morphological
changes
(Hoechst
33342/Propidium
iodide
(PI)
staining)
confirmed
Annexin
V/PI
staining
analysis.
addition,
disruption
mitochondrial
membrane
(MMP)
generation
reactive
oxygen
species
(ROS)
determined
JC-1
indicator
DCFDA
dye,
respectively.
results
demonstrated
that
24
h
treatment
significantly
suppressed
MDA-MB-231
cells
dose-dependent
manner
IC