Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 27, 2023
Abstract
Heavy
metal
pollutants
are
widely
present
in
a
variety
of
environments,
and
several
studies
have
shown
that
exposure
to
heavy
metals
is
associated
with
the
risk
atherosclerosis.
However,
underlying
mechanism
this
association
remains
unclear.AIP,
as
biomarker
for
predicting
cardiovascular
events,
can
reflect
atherosclerosis
severity
blood
vessel
stenosis.
Therefore,
explore
relationship
between
single
combined
plasma
index.
The
study
included
data
from
2015–2016
2017–2020
National
Health
Nutrition
Examination
Surveys
(NHANES)
assessed
mediating
role
inflammation
adults.
In
model,
positive
dose-response
was
observed
selenium
(Se)
AIP,
negative
correlation
cadmium
(Cd)
mercury
(Hg)
AIP.
We
construct
weighted
quantile
sum
(WQS)
regression
Bayesian
kernel
machine
(BKMR).In
WQS
AIP
increased
significantly
increase
concentration
mixed
metals,
while
BKMR
results
were
consistent,
statistical
significance.
addition,
mediated
analysis
showed
HS-CRP-mediated
elevations
11.83%
selenium-associated
indicated
caused
an
inflammatory
response
aggravated
progression.
Italian Journal of Food Safety,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
Heavy
metal(loid)s
(HM)
pollution
in
aquatic
environments
is
a
serious
issue
due
to
the
toxicity,
persistence,
bioaccumulation,
and
biomagnification
of
these
pollutants.
The
main
sources
HM
contamination
are
industrial
activities,
mining,
agricultural
practices,
combustion
fossil
fuels.
Fish
can
accumulate
HMs
through
process
called
bioaccumulation.
As
larger
predatory
fish
consume
smaller
fish,
enter
food
chains
become
increasingly
concentrated
their
tissues
finally
reach
humans.
Here,
we
provided
general
concise
conclusion
from
current
research
findings
on
toxicological
effects
different
body
systems.
Exposure
lead
range
adverse
health
effects,
including
neurological
damage,
developmental
disorders,
kidney
cardiovascular
problems,
cancers.
Their
long-term
accumulation
result
chronic
toxicity
even
at
low
levels
exposure.
exert
cellular
cytotoxicity
by
disrupting
essential
processes
structures.
They
interfere
with
enzyme
function,
disrupt
cell
membrane
integrity,
induce
oxidative
stress,
cause
DNA
ultimately
leading
death
or
dysfunction.
Prevention
control
involve
implementing
measures
reduce
release
into
environment
regulations
processes,
waste
management,
technologies.
Additionally,
monitoring
remediation
efforts
crucial
for
identifying
contaminated
sites
strategies
such
as
soil
water
human
exposure
mitigate
impact
ecosystems.
To
conclude,
poses
risks
public
environment,
necessitating
urgent
interdisciplinary
harmful
promote
sustainable
practices
that
flow
biological
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 27, 2023
Abstract
Heavy
metal
pollutants
are
widely
present
in
a
variety
of
environments,
and
several
studies
have
shown
that
exposure
to
heavy
metals
is
associated
with
the
risk
atherosclerosis.
However,
underlying
mechanism
this
association
remains
unclear.AIP,
as
biomarker
for
predicting
cardiovascular
events,
can
reflect
atherosclerosis
severity
blood
vessel
stenosis.
Therefore,
explore
relationship
between
single
combined
plasma
index.
The
study
included
data
from
2015–2016
2017–2020
National
Health
Nutrition
Examination
Surveys
(NHANES)
assessed
mediating
role
inflammation
adults.
In
model,
positive
dose-response
was
observed
selenium
(Se)
AIP,
negative
correlation
cadmium
(Cd)
mercury
(Hg)
AIP.
We
construct
weighted
quantile
sum
(WQS)
regression
Bayesian
kernel
machine
(BKMR).In
WQS
AIP
increased
significantly
increase
concentration
mixed
metals,
while
BKMR
results
were
consistent,
statistical
significance.
addition,
mediated
analysis
showed
HS-CRP-mediated
elevations
11.83%
selenium-associated
indicated
caused
an
inflammatory
response
aggravated
progression.
