Association of inflammation-mediated blood heavy metals with plasma atherogenic index: NHANES analysis 2015-2020 DOI Creative Commons

xue Wang,

Ming Zhang

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 27, 2023

Abstract Heavy metal pollutants are widely present in a variety of environments, and several studies have shown that exposure to heavy metals is associated with the risk atherosclerosis. However, underlying mechanism this association remains unclear.AIP, as biomarker for predicting cardiovascular events, can reflect atherosclerosis severity blood vessel stenosis. Therefore, explore relationship between single combined plasma index. The study included data from 2015–2016 2017–2020 National Health Nutrition Examination Surveys (NHANES) assessed mediating role inflammation adults. In model, positive dose-response was observed selenium (Se) AIP, negative correlation cadmium (Cd) mercury (Hg) AIP. We construct weighted quantile sum (WQS) regression Bayesian kernel machine (BKMR).In WQS AIP increased significantly increase concentration mixed metals, while BKMR results were consistent, statistical significance. addition, mediated analysis showed HS-CRP-mediated elevations 11.83% selenium-associated indicated caused an inflammatory response aggravated progression.

Language: Английский

Heavy metal(loid) bioaccumulation in fish and its implications for human health DOI Creative Commons
Dhary Alewy Almashhadany,

Rzgar Farooq Rashid,

K. I. Altaif‎

et al.

Italian Journal of Food Safety, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Heavy metal(loid)s (HM) pollution in aquatic environments is a serious issue due to the toxicity, persistence, bioaccumulation, and biomagnification of these pollutants. The main sources HM contamination are industrial activities, mining, agricultural practices, combustion fossil fuels. Fish can accumulate HMs through process called bioaccumulation. As larger predatory fish consume smaller fish, enter food chains become increasingly concentrated their tissues finally reach humans. Here, we provided general concise conclusion from current research findings on toxicological effects different body systems. Exposure lead range adverse health effects, including neurological damage, developmental disorders, kidney cardiovascular problems, cancers. Their long-term accumulation result chronic toxicity even at low levels exposure. exert cellular cytotoxicity by disrupting essential processes structures. They interfere with enzyme function, disrupt cell membrane integrity, induce oxidative stress, cause DNA ultimately leading death or dysfunction. Prevention control involve implementing measures reduce release into environment regulations processes, waste management, technologies. Additionally, monitoring remediation efforts crucial for identifying contaminated sites strategies such as soil water human exposure mitigate impact ecosystems. To conclude, poses risks public environment, necessitating urgent interdisciplinary harmful promote sustainable practices that flow biological

Language: Английский

Citations

0

Associations between Serum Metal Mixtures and Systemic Inflammation Indices Among Chinese Early Adolescents: A Prospective Cohort Study DOI
Yonghan Li, Binbin Huang, Mengyuan Yuan

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0

Association of inflammation-mediated blood heavy metals with plasma atherogenic index: NHANES analysis 2015-2020 DOI Creative Commons

xue Wang,

Ming Zhang

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 27, 2023

Abstract Heavy metal pollutants are widely present in a variety of environments, and several studies have shown that exposure to heavy metals is associated with the risk atherosclerosis. However, underlying mechanism this association remains unclear.AIP, as biomarker for predicting cardiovascular events, can reflect atherosclerosis severity blood vessel stenosis. Therefore, explore relationship between single combined plasma index. The study included data from 2015–2016 2017–2020 National Health Nutrition Examination Surveys (NHANES) assessed mediating role inflammation adults. In model, positive dose-response was observed selenium (Se) AIP, negative correlation cadmium (Cd) mercury (Hg) AIP. We construct weighted quantile sum (WQS) regression Bayesian kernel machine (BKMR).In WQS AIP increased significantly increase concentration mixed metals, while BKMR results were consistent, statistical significance. addition, mediated analysis showed HS-CRP-mediated elevations 11.83% selenium-associated indicated caused an inflammatory response aggravated progression.

Language: Английский

Citations

0