Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge DOI Creative Commons
Francesca Gorini, Alessandro Tonacci

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 938 - 938

Published: Aug. 1, 2024

Frontotemporal dementia (FTD) includes a number of neurodegenerative diseases, often with early onset (before 65 years old), characterized by progressive, irreversible deficits in behavioral, linguistic, and executive functions, which are difficult to diagnose due their similar phenotypic characteristics other dementias psychiatric disorders. The genetic contribution is utmost importance, although environmental risk factors also play role its pathophysiology. In fact, some metals known produce free radicals, which, accumulating the brain over time, can induce oxidative stress, inflammation, protein misfolding, all these being key features FTD conditions. Therefore, present review aims summarize current evidence about FTD-mainly dealing toxic metal exposure-since identification such potential lead diagnosis promotion policies interventions. This would allow us, reducing exposure pollutants, potentially affect society at large positive manner, decreasing burden conditions on affected individuals overall. Future perspectives, including application Artificial Intelligence principles field, related found so far, introduced.

Language: Английский

Cadmium neurotoxicity: Insights into behavioral effect and neurodegenerative diseases DOI

Kimia Rezaei,

Ghazaleh Mastali, Elham Abbasgholinejad

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143180 - 143180

Published: Aug. 24, 2024

Language: Английский

Citations

9
The Role of SIRT1–BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells DOI Creative Commons
Bo Yang, Feiqing Wang, Yang Xu

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Chronic fluorosis is often accompanied by neurological symptoms, leading to attention, memory and learning ability decline causing tension, anxiety, depression, other mental symptoms. In the present study, we analyzed molecular mechanisms of SIRT1-BDNF regulation PI3K-AKT, MAPK, FOXO1A in F-treated BV2 cells. The cytotoxic effect sodium fluoride (NaF) on cells was assessed using Cell Counting Kit-8 (CCK-8), crystal violet, 5-ethynyl-2'-deoxyuridine (EdU) staining. cycle progression apoptosis were evaluated through flow cytometry western blotting. Reactive oxygen species (ROS) levels, oxidative stress, inflammatory markers measured ROS staining, microplate reader assays, role SIRT1 fluoride-induced toxicity for glial determined activator SRT1720. experiments demonstrated that NaF toxic cells, inhibited their proliferative ability, halted cell progression, triggered cellular apoptosis, promoted stress (detected ROS, SOD, MDA, GSH-Px, T-AOC) associated protein NQO-1 HO-1, elevated mediator IL-1and IL-6 expression). fluoride-exposed groups had reduced SIRT1, BDNF, TrkB, PI3K, AKT, MAPK expression increased expression. SRT1720 mitigated harmful effects NaF, stimulated proliferation decreased factors, suppressed results indicate potentially harms suppressing activation, significantly damage. Furthermore, signaling pathway might regulate nerve damage caused poisoning may be a protective factor treating brain injury.

Language: Английский

Citations

1
Pregnancy and Postpartum Effects of Electronic Cigarettes on Maternal Health and Vascular Function in the Fourth Trimester DOI Creative Commons
Amber Mills, Duaa Dakhlallah, Anand Ranpara

et al.

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Pregnancy is a vulnerable time with significant cardiovascular changes that can lead to adverse outcomes, which extend into the postpartum window. Exposure emissions from electronic cigarettes (Ecig), commonly known as "vaping," has an impact on function during pregnancy and post-natal life of offspring, but effects maternal health are poorly understood. We used Sprague Dawley rat model, where pregnant dams exposed Ecigs between gestational day (GD)2-GD21 examine consequences. Litter dam were monitored weaning period, vascular endocrine assessed after weaning. Ecig led fetal losses (i.e., reabsorption in utero) reduced survival pups compared controls (air-exposed dams). find vaping pregnancy, or without nicotine (or flavoring) results hormonal dysfunction prolactin, increased expression sirtuin 1 deacetylase brain). Both 5 30W aerosol exposures resulted impairment middle cerebral artery reactivity acetylcholine-mediated dilation (decreasing ~ 22 50%, respectively). also observed increase number extracellular vesicles (EVs) plasma 30-W group persists up 3-week these EVs impaired endothelial cell when applied vitro ex vivo assays. Our data suggest (1) vaping, even flavorings, alters circulating factors influence health, (2) may contribute etiology dysfunction, (3) window for recovery likely be longer than exposure

Language: Английский

Citations

0
Eucalyptol Attenuates Lead-Induced Anxiety-like Behaviors by Suppressing Oxidative Stress and Neuroinflammation, Modulating SIRT1/NF-κB Signaling, and Upregulating BDNF Expression DOI
Masoumeh Asle‐Rousta,

Mojdeh Abdollahi,

Hossein Moghadam Aghajari

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge DOI Creative Commons
Francesca Gorini, Alessandro Tonacci

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 938 - 938

Published: Aug. 1, 2024

Frontotemporal dementia (FTD) includes a number of neurodegenerative diseases, often with early onset (before 65 years old), characterized by progressive, irreversible deficits in behavioral, linguistic, and executive functions, which are difficult to diagnose due their similar phenotypic characteristics other dementias psychiatric disorders. The genetic contribution is utmost importance, although environmental risk factors also play role its pathophysiology. In fact, some metals known produce free radicals, which, accumulating the brain over time, can induce oxidative stress, inflammation, protein misfolding, all these being key features FTD conditions. Therefore, present review aims summarize current evidence about FTD-mainly dealing toxic metal exposure-since identification such potential lead diagnosis promotion policies interventions. This would allow us, reducing exposure pollutants, potentially affect society at large positive manner, decreasing burden conditions on affected individuals overall. Future perspectives, including application Artificial Intelligence principles field, related found so far, introduced.

Language: Английский

Citations

3