Blood and Serum Copper and Zinc Levels and 10-Year Survival of Patients After Kidney Cancer Diagnosis DOI Open Access
Elżbieta Złowocka-Perłowska, Piotr Baszuk, Wojciech Marciniak

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 944 - 944

Published: March 8, 2025

Background/Objectives: Copper (Cu) and zinc (Zn) are essential trace elements, an imbalance in their levels may influence the progression of cancer. The role Cu Zn blood serum, as well 10-year survival rates kidney cancer patients, remains unclear. Our objective was to determine association between these micronutrients mortality patients. In this prospective study, we examined 284 consecutive, unselected patients assessed relation levels. Methods: Micronutrient were measured using inductively coupled plasma mass spectrometer. Each patient categorized into one four groups based on distribution levels, ranked increasing order. multivariable models included factors such age at diagnosis, gender, smoking history, type surgery, histopathological results. Results: We observed a significantly higher risk all-cause with highest or serum copper compared those lower (blood: HR = 4.89; p < 0.001; serum: 3.75; 0.001). With regard zinc, found trend where (I quartile) associated mortality. Additionally, identified significant correlation Zn/Cu ratio Conclusions: Patients lowest quartile had elevated hazard ratios HRs 3.05 (p 0.002) 5.72 0.001) serum. To our knowledge, study is first investigate relationship survival.

Language: Английский

Blood and Serum Copper and Zinc Levels and 10-Year Survival of Patients After Kidney Cancer Diagnosis DOI Open Access
Elżbieta Złowocka-Perłowska, Piotr Baszuk, Wojciech Marciniak

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 944 - 944

Published: March 8, 2025

Background/Objectives: Copper (Cu) and zinc (Zn) are essential trace elements, an imbalance in their levels may influence the progression of cancer. The role Cu Zn blood serum, as well 10-year survival rates kidney cancer patients, remains unclear. Our objective was to determine association between these micronutrients mortality patients. In this prospective study, we examined 284 consecutive, unselected patients assessed relation levels. Methods: Micronutrient were measured using inductively coupled plasma mass spectrometer. Each patient categorized into one four groups based on distribution levels, ranked increasing order. multivariable models included factors such age at diagnosis, gender, smoking history, type surgery, histopathological results. Results: We observed a significantly higher risk all-cause with highest or serum copper compared those lower (blood: HR = 4.89; p < 0.001; serum: 3.75; 0.001). With regard zinc, found trend where (I quartile) associated mortality. Additionally, identified significant correlation Zn/Cu ratio Conclusions: Patients lowest quartile had elevated hazard ratios HRs 3.05 (p 0.002) 5.72 0.001) serum. To our knowledge, study is first investigate relationship survival.

Language: Английский

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