Human & Experimental Toxicology, Journal Year: 2025, Volume and Issue: 44
Published: May 1, 2025
Background Praseodymium (Pr), Samarium (Sm), Lanthanum (La), and Terbium (Tb) are rare earth elements (REEs) that can accumulate in the body induce oxidative stress (OS), which may contribute to polycystic ovary syndrome (PCOS), a condition affecting 116 million women worldwide. With increasing use of REEs, understanding their role PCOS is crucial. Design This case-control study included 56 cases 50 healthy controls, with confounding factors such as age, BMI, hormones controlled. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used measure serum levels Pr, Sm, La, Tb, Pearson correlation performed explore relationship markers malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD). Result A significant increase Tb observed compared controls ( p < 0.05). The 95% confidence intervals (CIs) for differences were [0.0008, 0.0032], [0.0002, 0.0091], [0.0019, 0.0073], 0.0129], respectively. Additionally, MDA significantly elevated, accompanied by reduction antioxidant markers-GSH SOD 0.001). Elevated REE positively correlated increased negatively GSH SOD, indicating stress. Conclusion These findings suggest stress-induced metal intoxication play critical development PCOS. Future studies should clinical significance exposure its potential target preventive strategies management.
Language: Английский