Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Acute pancreatitis (AP) is a severe inflammatory disorder of the pancreas, characterized by high morbidity and mortality rates. Despite significant advancements in understanding pathophysiological mechanisms AP, current treatment options still face considerable limitations. Recent studies have underscored therapeutic potential quercetin, natural flavonoid, due to its potent antioxidant, anti-inflammatory, immunomodulatory properties, positioning it as promising candidate for AP. This review explores effects quercetin on highlighting antioxidant activities, role immune modulation, protective pancreatic tissue. Furthermore, examines quercetin's multi-target advantages over conventional therapies, such N-acetylcysteine corticosteroids. Although preliminary suggest that can alleviate inflammation oxidative stress clinical evidence remains limited. One main challenges application low bioavailability. Future research should focus strategies enhance bioavailability conducting large-scale randomized controlled trials more comprehensively assess efficacy safety

Language: Английский