Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models DOI Creative Commons
Xinyu Zhang, Kelu Yang, Yang Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: June 29, 2022

Chemotherapy has significantly improved cancer survival rates at the cost of irreversible and frequent cardiovascular toxicity. As main dose-dependent adverse effect, cardiotoxic effects not only limit usage chemotherapeutic agents, but also cause high risk severe poor prognoses for survivors. Therefore, it is great significance to seek more effective cardioprotective strategies. Some nutrients have been reported diminish cardiac oxidative damage associated with chemotherapy. However, currently available evidence unclear, which requires a rigorous summary. such, we conducted systematic review all demonstrated whether derived from food could prevent cardiotoxicity caused by chemotherapy.We searched Medline (via PubMed), Embase Cochrane Library inception Nov 9, 2021 identify studies reporting dietary against chemotherapy-related cardiotoxicity. We performed descriptive summaries on included studies, used forest plots demonstrate various nutrients.Fifty-seven eligible were identified, involving 53 animal carried rats or mice four human in patients. Seven types recognized including polyphenols (mainly extracted grapes, grape seeds, tea), allicin form garlic), lycopene tomatoes), polyunsaturated fatty acids, amino acids referring glutamine), coenzyme Q10, trace elements zinc selenium). Dietary ameliorated left ventricular dysfunctions myocardial stress varying degrees, The overall bias was moderate risk.The results indicated that might be potential strategy protect system exposed are urged this field.Systematic Review Registration: https://inplasy.com/inplasy-2022-3-0015/.

Language: Английский

Sulforaphane, an Nrf-2 Agonist, Modulates Oxidative Stress and Inflammation in a Rat Model of Cuprizone-Induced Cardiotoxicity and Hepatotoxicity DOI Creative Commons
Ghadha Ibrahim Fouad

Cardiovascular Toxicology, Journal Year: 2023, Volume and Issue: 23(1), P. 46 - 60

Published: Jan. 1, 2023

Cuprizone (CPZ) is a neurotoxic agent that used to induce demyelination and neurotoxicity in rats. This study aimed investigate the protective potential of sulforaphane (SF), nuclear factor E2 related (Nrf-2) activator, against CPZ-induced cardiotoxicity hepatotoxicity. Male adult Wistar rats (n = 18) were fed with regular diet or CPZ-contained (0.2%) for four weeks. The divided into three groups 6): negative control rats, CPZ-exposed CPZ + SF treated was intraperitoneally administrated (2 mg/kg/day) two anti-inflammatory anti-oxidative functions investigated biochemically, histologically, immunohistochemically. increased serum levels cardiac troponin 1 (CTn1), aspartate amino transaminase (AST), alanine (ALT), alkaline phosphatase (ALP). In addition, inflammatory interferon-gamma (IFN-γ), pro-inflammatory interleukin 1β (IL-1β) significantly elevated. Moreover, administration provoked oxidative stress as manifested by declined total antioxidant capacity (TAC), well as, stimulated lipid peroxidation decreased catalase activities both hepatic tissues. treatment reversed all these biochemical alterations through exerting activities, this supported histopathological investigations SF-triggered modulation inflammation strongly associated Nrf-2 activation, evidenced activated immunoexpression highlights cardioprotective hepatoprotective via activation enhancing function.

Language: Английский

Citations

12
Liraglutide Pretreatment Does Not Improve Acute Doxorubicin-Induced Cardiotoxicity in Rats DOI Open Access
Carolina Rodrigues Tonon, Marina Gaiato Monte, Paola da Silva Balin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5833 - 5833

Published: May 27, 2024

Doxorubicin is an effective drug for cancer treatment; however, cardiotoxicity limits its use. Cardiotoxicity pathophysiology multifactorial. GLP-1 analogues have been shown to reduce oxidative stress and inflammation. In this study, we evaluated the effect of pretreatment with liraglutide on doxorubicin-induced acute cardiotoxicity. A total 60 male Wistar rats were allocated into four groups: Control (C), (D), Liraglutide (L), + (DL). L DL received subcutaneous injection 0.6 mg/kg daily, while C D saline 2 weeks. Afterwards, a single intraperitoneal doxorubicin 20 mg/kg; saline. Forty-eight hours after administration, subjected echocardiogram, isolated heart functional euthanasia. Liraglutide-treated ingested significantly less food gained body weight than animals that did not receive drug. Rats lost injection. At echocardiogram doxorubicin-treated had systolic diastolic function impairment. Myocardial catalase activity was statistically higher in rats. protein expression tumor necrosis factor alpha (TNF-α), phosphorylated nuclear factor-κB (p-NFκB), troponin T, B-cell lymphoma (Bcl-2) lower, NFκB/p-NFκB ratio TLR-4 OPA-1, MFN-2, DRP-1, topoisomerase 2β differ between groups (p > 0.05). conclusion, accompanied by decreased Bcl-2 NFκB increased expression. failed improve

Language: Английский

Citations

4
Mitigating doxorubicin-induced hepatotoxicity in male rats: The role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis DOI Creative Commons

Amir Mohammad Zobeydi,

Seyede Nasim Mousavi Namavar,

Maryam Sadeghi Shahdani

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Doxorubicin (DOXO) is a powerful anthracycline chemotherapeutic drug, but its clinical usage has been limited by deleterious effects on different organs, particularly hepatotoxicity. The aim of this study was to establish the combined aerobic interval training (AIT) and curcumin supplementation mitigating oxidative damage endoplasmic reticulum (ER) stress-mediated apoptosis in rat model DOXO-induced Fifty-six male Sprague–Dawley rats were randomly split into six groups: control (CON), vehicle, doxorubicin (Dox), + (Dox-C), AIT (Dox-A), (Dox-AC). DOXO intraperitoneally injected weekly (4 mg/kg/week) for five weeks. Curcumin (100 mg/kg/day) min at 80–90% VO2max intermitted 3 active rest 65–75% VO2max) conducted times week Finally, hepatic tissue blood samples collected assess histopathological changes, liver biomarkers, protein expression stress, ER markers. Tissue sections revealed that significantly improved hepatotoxicity induced DOXO, as evidenced positive alterations serum markers (P < 0.05). Both reduced DOXO-triggered damage, 0.05), with latter showing slightly higher effectiveness. Consequently, combination exhibits protective against chronic demonstrating relatively greater efficacy increasing antioxidant capacity reducing stress apoptosis.

Language: Английский

Citations

0
Doxorubicin-Induced Cardiac Remodeling: Mechanisms and Mitigation Strategies DOI
Yingpu Sun, Lili Xiao, Linlin Chen

et al.

Cardiovascular Drugs and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
Gallic and glycyrrhetinic acids prevent azithromycin-induced liver damage in rats by mitigating oxidative stress and inflammation DOI Creative Commons

Marwa Amer Ali,

Asmaa I. Matouk, Alaaeldin Ahmed Hamza

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 20, 2025

Natural products like gallic acid (GA), a phenolic compound, and glycyrrhetinic (GLA), pentacyclic triterpene, have been shown to exhibit antioxidant, ant-inflammatory, hepatoprotective properties. This study aims investigate the protective effects of GA, GLA their combination explore underlying mechanisms against acute liver damage induced by azithromycin (AZM) in rats. Seven groups male Wistar rats were used namely control, GLA, AZM, AZM + GA groups. We treated for 21 days, administering at 50 mg/kg one week prior (30 mg/kg). Serum levels aspartate aminotransferase, alanine alkaline phosphatase AZM-induced pre-treated with therapy much lower than those group Elevated glutathione, catalase, superoxide dismutase preventive demonstrated that combinations notably reduced malondialdehyde levels, an oxidative stress marker, improving antioxidant system Furthermore, pro-inflammatory cytokines, such as tumor necrosis factor-α nuclear factor kappa beta (NF-kB), thus reversing hepatic inflammation. also discovered down-regulated erythroid 2-related 2 (Nrf2), its normal restored post treatments suggesting Nrf2 signaling pathway-mediated prevention damage. In conclusion, protected injury through ability inflammation preventing downregulation upregulation NF-kB. After determining efficacy safety clinical settings future studies, could potentially make useful therapeutic drugs mitigate hepatotoxicity.

Language: Английский

Citations

0
Molecular mechanisms of Taurine in mitigating doxorubicin-induced cardiotoxicity: therapeutic potential and insights DOI
Pandi Anandakumar,

N. B. Sen,

Balarko Chakraborty

et al.

The Nucleus, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Luteolin mitigates doxorubicin-induced hepatotoxicity and neurotoxicity: modulating the liver–brain axis via IRE1α/GRP78/ATF6 endoplasmic reticulum stress pathways and miRNA-199a-5p expression DOI Creative Commons

Rasha D. Abdrabou,

Rania M. Salama, Reem N. El‐Naga

et al.

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 14, 2025

Abstract Background Doxorubicin (DOX) has long been a foundational drug in cancer therapeutics. Despite its proven efficacy, the persistent challenge of mitigating associated side effects, notably hepatotoxicity and neurotoxicity, underscores necessity for intervention. Luteolin (LUT) is naturally derived flavonoid with spectrum bioactive characteristics, involving anti-apoptotic, antioxidant, anti-inflammatory, anti-cancer attributes. This study investigates possible protective effect LUT against DOX-induced focusing on modulation endoplasmic reticulum (ER) stress pathways miRNA 199a- 5p expression. Forty-eight male Sprague Dawley rats were assigned to six groups: control, (200 mg/kg), DOX (3.5 mg/kg, i.p.) administered twice per week 3 weeks, three treatment groups that received daily oral gavage at doses 50, 100, 200 mg/kg weeks alongside DOX. Results Behavioral assessments revealed best improvements co-treated high dose paralleled by mitigation neurodegeneration cortex hippocampal areas brain. The hepatoprotective mg/kg) demonstrated notable decrease liver enzymes restoration hepatocytic architecture, coupled upregulation miRNA-199a-5p suppression glucose-regulated protein 78 (GRP78). inhibited ER via suppressing inositol-requiring enzyme 1 alpha (IRE1α)/protein kinase R-like (PERK)/eukaryotic initiation factor 2 (eIF2α)/activating transcription 6 (ATF6) axes, thereby inhibiting apoptosis. Conclusions efficacious alleviating hepatic injury neurotoxicity dampening pathways. Graphical abstract

Language: Английский

Citations

0
NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: role of phytochemicals DOI Creative Commons
Xiaopeng Zhao,

Lian Duan,

Qianru Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Doxorubicin (DOX) has received widespread attention as a broad-spectrum antitumor drug. However, it been recognized challenge that long-term DOX injections can lead to severe cardiotoxicity. There are numerous interventions DOX-induced cardiotoxicity, and the most cost-effective is phytochemicals. It reported phytochemicals have complex diverse biological properties, facilitating mitigation of cardiotoxicity pathological mechanisms, nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis one them. This review initially presents an overview mechanisms underlie induced by DOX. Subsequently, we present comprehensive elucidation structure activation NLRP3 inflammasome. Finally, provide detailed summary mitigate influencing expression inflammasome in cardiomyocytes.

Language: Английский

Citations

0
Assessment of the gold nanoparticles biosynthesized using Casuarina equisetifolia bark extract against the ethion induced Hepato- and neurotoxicity in rats DOI
Wael M. Aboulthana, Noha E. Ibrahim, Amal G. Hussien

et al.

Journal of Genetic Engineering and Biotechnology, Journal Year: 2025, Volume and Issue: 23(2), P. 100495 - 100495

Published: April 24, 2025

Language: Английский

Citations

0
Protection against cancer therapy-induced cardiovascular injury by planed-derived polyphenols and nanomaterials DOI

Yunshu Liao,

Qinghua Meng

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 116896 - 116896

Published: Aug. 14, 2023

Language: Английский

Citations

10