Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 103 - 103

Published: Feb. 6, 2024

Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment

Language: Английский

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Promotion of osteochondral repair through immune microenvironment regulation and activation of endogenous chondrogenesis via the release of apoptotic vesicles from donor MSCs

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 455 - 470

Published: Aug. 6, 2024

Utilizing transplanted human umbilical cord mesenchymal stem cells (HUMSCs) for cartilage defects yielded advanced tissue regeneration, but the underlying mechanism remain elucidated. Early after HUMSCs delivery to defects, we observed substantial apoptosis. The released apoptotic vesicles (apoVs) of promoted regeneration by alleviating chondro-immune microenvironment. ApoVs triggered M2 polarization in macrophages while simultaneously facilitating chondrogenic differentiation endogenous MSCs. Mechanistically, macrophages, miR-100-5p delivered apoVs activated MAPK/ERK signaling pathway promote polarization. In MSCs, let-7i-5p targeting eEF2K/p38 MAPK axis. Consequently, a cell-free strategy using combined with decellularized extracellular matrix (DCM) scaffold effectively osteochondral defects. Overall, new mechanisms MSCs were unconcealed this study. Moreover, provided novel experimental basis engineering-based utilizing apoVs.

Language: Английский

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Anoikis-related genes in breast cancer patients: reliable biomarker of prognosis

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 19, 2024

Language: Английский

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Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1561 - 1561

Published: Jan. 26, 2024

Autophagy, a complex and highly regulated cellular process, is critical for the maintenance of homeostasis by lysosomal degradation debris, intracellular pathogens, dysfunctional organelles. It has become an interesting attractive topic in cancer because its dual role as tumor suppressor cell survival mechanism. As conserved pathway, autophagy strictly diverse non-coding RNAs (ncRNAs), ranging from short flexible miRNAs to lncRNAs even circRNAs, which largely contribute regulatory networks via RNA interactions. The potential roles interactions during autophagy, especially procession further anticancer treatment, will aid our understanding related tumorigenesis treatment. Herein, we mainly summarized autophagy-related mRNAs ncRNAs, also providing RNA–RNA their prognosis, may deepen relationships between various provide new insights into therapeutic strategies personalized medicine.

Language: Английский

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The Efficacy of Curcumin Application to Melanoma in Mice

Annals of Plastic Surgery, Journal Year: 2024, Volume and Issue: 93(2S), P. S75 - S81

Published: Aug. 1, 2024

Objective Melanoma is a skin tumor that poses serious threat to human health. Our study explores the effectiveness and safety of curcumin in treatment melanoma based on animal models, providing evidence-based medical evidence for malignant melanoma. Methods The collected all randomized controlled trial data from establishment database October 2023 mice by searching PubMed, Embase, Cochrane Library. According inclusion exclusion criteria, were extracted quality assessment included studies was performed using SYRCLE (Systematic Review Center Laboratory Experimentation) experiment bias risk tool. RevMan 5.4 Stata 15.1 software used meta-analysis. Results Eighteen trials this with total 185 mouse including 93 experimental group 92 control group. results meta-analysis showed IC 50 (inhibitory concentrations 50%) lower than [standardized mean difference (SMD) = −4.68, 95% confidence interval (CI) (−7.30, −2.06), P < 0.01]; volume significantly smaller [SMD −3.10, CI (−4.45, −1.75), weight −3.01, (−4.81, −1.21), 0.01]. However, there no significant statistical apoptosis rate between 2.27, (−1.39, 5.92), Conclusion Based models meta-analysis, can inhibit growth proliferation mice. may be an effective method treating result still requires further in-depth research.

Language: Английский

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hsa-miR-3529-5p through F2RL3 Regulation as an Enhancer of Sensitivity to Cisplatin

Indian Journal of Clinical Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Language: Английский

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The role and mechanism of AZD5363 anti-leukemia activity in T-cell acute lymphoblastic leukemia

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 963, P. 176268 - 176268

Published: Dec. 12, 2023

Language: Английский

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