Investigation of Substance Basis and Pharmacodynamics of Qingzao Jiefei Decoction in Lung Cancer based on Serum Pharmacochemistry and Proteomics

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Qingzao Jiufei Decoction (QD) is a renowned prescription for nourishing lung Yin to treat lung-related diseases in ancient and modern times. It has been reported that QD can effectively inhibit the growth of cancer (LC), but material basis mechanism its treatment LC remain be further studied. In this experiment, we combined serum pharmacochemistry proteomics study pharmacodynamic against LC. The results showed vitro total 121 compounds were identified. A 33 prototype chemical components identified vivo, which may effective active ingredients Proteomic experiments have shown compared with model group, 113 DEPs tissues significantly changed after treatment, among 57 proteins up-regulated 56 down-regulated (p < 0.05). Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis was performed on these DEPs. 205 pathways enriched, PI3K-Akt signaling pathway experimentally verified. used by inhibiting activation PI3K/Akt/mTOR pathway.

Language: Английский

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The traditional Chinese medicine formula Zhihan Anshen Tang (ZHAST) against obstructive sleep apnea hypopnea syndrome: network pharmacology and molecular docking approach

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 10, 2025

Introduction The current treaments for Obstructive Sleep Apnea Hypopnea (OSAHS) are Continuous Positive Airway Pressure (CPAP) and lifestyle modifications, which is not suitable all patients. Traditional Chinese medicine (TCM) has increasingly demonstrated its efficacy benefits in treating OSAHS. Zhihan Anshen Tang (ZHAST), been clinical metrics OSAHS However, key ingredients mechanisms of action still unknown. Methods Using network pharmacology, we investigated the potential ZHAST through Results In addition, targets, including TNF, IL6, GAPDH, STAT3, HIF1A, JUN, revealed by topological analysis. According to findings GO enrichment analysis, genes were enriched inflammatory responses, hypoxia positive regulation angiogenesis, protein phosphorylation, cell proliferation. KEGG pathway analysis suggests that signaling MAPK AGE-RAGE pathway, especially diabetic complications. it enoxolone ZHASTs have high affinity with relevant targets molecular docking dynamics simulations. Disscussion To my knowledge, this first pharmacological study about a effective against OSA. This investigation integrates pharmacology identify compounds, related mechanism treatment OSAHS, providing prospect traditional medicines modern medical research.

Language: Английский

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Liquiritigenin protects against cadmium-induced testis damage in mice by inhibiting apoptosis and activating androgen receptor

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151642 - 151642

Published: March 1, 2025

Language: Английский

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Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

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Mechanistic Study of Liquiritigenin Inhibiting Bladder Cancer Cell Proliferation and Migration by Regulating STING1

Cancer Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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