The Novel Nephroprotective Activity of Flaxseed Oil on Diazinon-induced Kidney Damage in Male Rats DOI

Narges Farokhi,

Akram Ranjbar,

Fereshteh Mehri

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Language: Английский

Dual inhibition of canonical and noncanonical PAR‐1 by SCH79797 mitigates neurodegeneration in 3‐NP‐induced Huntington's disease: An in vivo and in silico approach DOI
Raghda T. Abdel‐Latif, Hanan S. El‐Abhar, Dalaal M. Abdallah

et al.

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Though abnormal platelet function is detected in Huntington's disease (HD), thrombin's role indistinct. Through protease‐activated receptor 1 (PAR‐1) activation, thrombin triggers intricate pathways relevant to HD. Therefore, we propose that posttreatment with the PAR‐1 inhibitor SCH79797 may alleviate symptoms a 3‐nitropropionic acid (3‐NP) HD model. Wistar rats were administered 3‐NP alone or treated SCH79797. In silico study showed better blood–brain barrier (BBB) diffusion by than vorapaxar. Docking blocks thrombin/PAR‐1 binding and directly inhibits metalloproteinase (MMP)‐1. Molecular dynamics confirmed minimal energy deviation stable interactions both MMP‐1 root mean square (RMSD) verified conformational stability. vivo part, behavioral striatal improvements observed, reducing levels of MMP‐1, expression PAR‐1, N ‐methyl‐ d ‐aspartate (NMDA) subunits (1 2B), MMP‐9, while increasing claudin‐5, contributing BBB integrity. also lowered tumor necrosis factor (TNF)‐α mitofusin (Mfn)‐2, rebalanced redox system malondialdehyde (MDA) enhancing superoxide dismutase (SOD), prevented 3‐NP‐induced mitophagy via PTEN‐induced kinase (PINK)‐1/ubiquitin pathway. inhibited apoptosis, caspase‐3 cytochrome C, increased voltage‐dependent anion channel‐1 (VDAC1) maintain mitochondrial function. Overall, canonically noncanonically counter excitotoxicity, oxidative stress, inflammation, mitophagy, thereby preserving integrity, improving histological outcomes, performance.

Language: Английский

Citations

0
Inflammatory mediators-induced DNA damage in liver and brain injury: Therapeutic approach of 5-Methoy-N-acetyltryptamine DOI Creative Commons
Mai O. Kadry, Hanaa M. Ali

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101816 - 101816

Published: Nov. 15, 2024

The pathophysiology of hepatic and cerebral damage includes various molecular signalling pathways. Assessment inflammation-induced DNA is one the principal issues for investigating organ distortion mutation. current study was premeditated to discover prophylactic role 5-Methoy-N-acetyltryptamine (5-MNAT) and/or Quercetin (QR) versus sodium nitrite (NaNO

Language: Английский

Citations

1
Unlocking the neuroprotective potential of Ziziphora clinopodioides flavonoids in combating neurodegenerative diseases and other brain injuries DOI Open Access

Lili Gu,

Can Wang, Jiayi Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117744 - 117744

Published: Dec. 13, 2024

Language: Английский

Citations

1
Silibinin-loaded Nanostructured Lipid Carriers (NLCs) Ameliorated Lead-induced Acute Nephrotoxicity in Male Rats DOI
Sajjad Makhdoomi,

Saba Ariafar,

Fatemeh Mirzaei

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3619 - 3628

Published: Aug. 6, 2024

Language: Английский

Citations

0
The Novel Nephroprotective Activity of Flaxseed Oil on Diazinon-induced Kidney Damage in Male Rats DOI

Narges Farokhi,

Akram Ranjbar,

Fereshteh Mehri

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Language: Английский

Citations

0