Distinct Immune Landscape and Gene Expression Profiles in Breast Cancer: Young vs. Non-Young Patients
Abstract
Background
Breast
cancer
remains
a
prevalent
malignancy
worldwide,
particularly
affecting
younger
women
more
aggressively.
Significant
differences
in
clinical
and
biological
characteristics
exist
between
breast
with
young
patients
(BCY)
non-young
(BCNY).
However,
the
role
of
immune
microenvironment
these
is
not
fully
understood.Methods
Data
from
Molecular
Taxonomy
Cancer
International
Consortium
(METABRIC)
database
were
analyzed
to
compare
tumor-infiltrating
cells
(TIICs)
gene
expression
BCY
BCNY.
The
CIBERSORT
algorithm
was
used
estimate
relative
abundance
22
cell
types,
differentially
expressed
genes
(DEGs)
identified
using
"limma"
package
R.Results
group
had
higher
prevalence
M0
macrophages
activated
dendritic
cells,
while
BCNY
exhibited
greater
infiltration
CD4
memory
T
M2
macrophages,
neutrophils.
Differential
analysis
11
significantly
groups,
such
as
FDCSP
GABRP
upregulated
group.
GSEA
revealed
that
pro-inflammatory
pathways,
cytokine-cytokine
receptor
interaction,
enriched
group,
pathways
related
metabolism
extracellular
matrix
interactions
Kaplan-Meier
demonstrated
high
certain
genes,
NAT1,
CA12,
SRARP,
associated
better
relapse-free
survival.Conclusion
exhibit
distinct
landscape
characterized
by
levels
contributing
aggressive
disease
profile.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Language: Английский