Molecular Signatures DOI
Ankur Bhardwaj, S. Gupta

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 114

Published: Dec. 17, 2024

The discovery of biomarkers has revolutionized the field oncology, providing critical insights into processes tumour initiation and progression. Biomarkers, which can be genetic, proteomic, or metabolic in nature, serve as vital indicators for early cancer detection, prognosis, personalized treatment strategies. Tumour undergoes various stages characterized by alterations microenvironment, angiogenesis, ultimately metastasis. Understanding these at molecular level is crucial identifying reliable biomarkers. Recent advances high-throughput technologies such next-generation sequencing, mass spectrometry, advanced imaging techniques have significantly enhanced ability to discover validate new Despite promising advancements, challenges remain translation biomarker discoveries clinical practice. This chapter provides a detailed current state discovery, highlighting key findings future directions this rapidly evolving field.

Language: Английский

Misconceptions Thrive in the Field of Cancer as Technological Advances Continue to Confuse Stem Cell Biology DOI
Deepa Bhartiya,

Shruti Dutta,

Anish Tripathi

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

1
Hyperthermia for Targeting Cancer and Cancer Stem Cells: Insights from Novel Cellular and Clinical Approaches DOI
David M. Smadja

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(6), P. 1532 - 1539

Published: May 25, 2024

Language: Английский

Citations

4
Do PGCCs in Solid Tumors Appear Due to Treatment-related Stress or Clonal Expansion of CSCs that Survive Oncotherapy? DOI
Deepa Bhartiya,

Nripen Sharma,

Anish Tripathi

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
The Evolutionary Route of in vitro Human Spermatogenesis: What is the Next Destination? DOI Creative Commons
Merve Gizer, Selin Önen, Petek Korkusuz

et al.

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(6), P. 1406 - 1419

Published: April 29, 2024

Malfunction in spermatogenesis due to genetic diseases, trauma, congenital disorders or gonadotoxic treatments results infertility approximately 7% of males. The behavior spermatogonial stem cells (SSCs) within three-dimensional, multifactorial, and dynamic microenvironment implicates a niche that serves as repository for fertility, since can serve source mature functional male germ cells. Current protocols enable reprogramming somatic into induced pluripotent (iPSCs) their limited differentiation SSCs the range 0-5%. However, resulting human iPSC-derived haploid spermatogenic cell yield terms number functionality is currently insufficient transfer clinic therapeutic tool. In this article, we reviewed evolution experimental culture platforms introduced novel iPSCs-based approach vitro based on perspective bearing cellular, chemical, physical factors provide complex arrangement testicular seminiferous tubules embedded vascularized stroma. We believe bioengineered organoids supported by smart bio-printed microfluidic organ-on-a-chip systems offer efficient, precise, personalized autologous sources undergo spermatogenetic cycle, presenting promising tool infertile patients with complete aplasia.

Language: Английский

Citations

3
Cancer Represents Dysfunctions of Stem Cells Rather than Misbehavior of Differentiated Cells DOI
Deepa Bhartiya

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(7), P. 1995 - 1997

Published: July 30, 2024

Language: Английский

Citations

2
Epigenetic aspects of a putative mechanism of antitumor action of ferrocenylalkylazoles DOI

V.N. Babin,

Yu. А. Belousov, V. N. Kulikov

et al.

Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(10), P. 2815 - 2820

Published: Oct. 1, 2024

Language: Английский

Citations

0
Molecular Signatures DOI
Ankur Bhardwaj, S. Gupta

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 114

Published: Dec. 17, 2024

The discovery of biomarkers has revolutionized the field oncology, providing critical insights into processes tumour initiation and progression. Biomarkers, which can be genetic, proteomic, or metabolic in nature, serve as vital indicators for early cancer detection, prognosis, personalized treatment strategies. Tumour undergoes various stages characterized by alterations microenvironment, angiogenesis, ultimately metastasis. Understanding these at molecular level is crucial identifying reliable biomarkers. Recent advances high-throughput technologies such next-generation sequencing, mass spectrometry, advanced imaging techniques have significantly enhanced ability to discover validate new Despite promising advancements, challenges remain translation biomarker discoveries clinical practice. This chapter provides a detailed current state discovery, highlighting key findings future directions this rapidly evolving field.

Language: Английский

Citations

0