Egyptian Journal of Basic and Applied Sciences,
Journal Year:
2024,
Volume and Issue:
11(1), P. 719 - 742
Published: Dec. 2, 2024
The
prevalence
of
diabetes
mellitus
is
increasing,
and
well-known
conventional
medications
are
associated
with
harmful
effects.
Therefore,
this
study
aimed
to
identify
the
compounds
present
in
young
leaves
Daniellia
oliveri
assess
their
antidiabetic
potential
using
an
in-silico
model.
best
column
chromatographic
fraction
obtained
from
ethyl
acetate
was
analyzed
HRLC-MS
prominent
compounds.
identified
were
subjected
ADMET
prediction
online
servers
confirm
draggability.
In
addition,
screened
for
activity
against
type
2
molecular
docking.
Eight
peaks
identified,
viz;
gallic
acid,
2,6-dihydroxybenzoic
salicylic
caffeic
phenylacetaldehyde,
2,5-dimethylphenol,
3-(−4-Hydroxyphenyl)
propionic
16-hydroxyhexadecanoic
acid.
Most
phenolics
had
little
toxic
docking
results
revealed
potentials
inhibiting
therapeutic
targets
11β-hydroxysteroid
dehydrogenase
1,
human
salivary
alpha-amylase,
glycogen
phosphorylase,
protein
tyrosine
phosphatase
1B,
glutamine
fructose-6-phosphate
amidotransferase,
sirtuin
6,
dipeptidyl
peptidase
IV,
responsible
development
diabetes.
This
has
successfully
revalidated
provided
scientific
insight
into
usage
D.
managing
by
Nigerians.
However,
limitation
remains
purification
lead
that
can
serve
as
treatment
medicinal
practices.
Trends in Sciences,
Journal Year:
2024,
Volume and Issue:
21(8), P. 8287 - 8287
Published: June 1, 2024
The
spread
of
infectious
diseases
such
as
COVID-19
depends
on
complex
fluid
dynamics
interactions
between
pathogens
and
phases,
including
individual
droplets
multiphase
clouds.
Understanding
these
is
crucial
for
predicting
controlling
disease
spread.
This
applies
to
human
animal
exhalations,
coughs
sneezes,
well
bursting
bubbles
that
create
micron-sized
in
various
indoor
outdoor
environments.
By
exploring
case
studies
this
regard,
study
examines
the
emerging
field
transmission,
focusing
flows,
interfacial
turbulence,
pathogens,
traffic,
aerosol
ventilation,
breathing
microenvironments.
These
results
indicate
increased
ventilation
rates
local
methods
can
effectively
reduce
concentration
SARS-CoV-2-laden
aerosols
immediate
spaces
individuals.
In
a
displacement-ventilated
room,
both
neutral
unstable
conditions
were
more
effective
removing
breathed
from
air,
regardless
presence
test
subjects.
However,
stable
may
increase
risk
infection
individuals
living
confined
spaces.
Thus,
findings
are
useful
providing
practical
guidance
managing
airborne
infections.
HIGHLIGHTS
Fluid
affect
transmission
explored
flow,
dispersion,
respiratory
zones
Increased
SARS-CoV-2
Displacement
eliminates
under
Cramped
damp
environments
GRAPHICAL
ABSTRACT
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
470, P. 134179 - 134179
Published: March 30, 2024
Microplastics
(MPs)
and
fluoxetine
are
ubiquitous
emerging
pollutants
in
aquatic
environments
that
may
interact
with
each
other
due
to
the
carrier
effects
of
MPs,
posing
unpredictable
risks
non-target
organisms.
However,
limited
studies
have
focused
on
MPs
food
chain.
This
study
evaluated
influences
polystyrene
trophic
transfer
biotoxicity
a
simple
chain
composed
brine
shrimp
(Artemia
nauplii)
zebrafish
(Danio
rerio).
The
findings
revealed
enhanced
accumulation
waterborne
shrimp,
but
suppressed
distinct
retention
times.
accumulated
was
further
transferred
fish
through
chain,
which
alleviated
by
their
cleaning
effects.
In
addition,
specific
neurotransmission
induced
mitigated
whilst
oxidative
damage,
apoptosis,
immune
responses
were
reversely
stimulating
effect.
These
highlight
alleviating
providing
new
insights
into
context
increasing
global
MP
pollution.
microplastics
attracted
rapidly
attention
potential
threats
organisms,
particularly
knowledge
regarding
is
still
poorly
understood
Herein,
we
investigated
co-existing
results
finding
provides
under
microplastic
International Journal of Newgen Research in Pharmacy & Healthcare,
Journal Year:
2024,
Volume and Issue:
unknown, P. 248 - 254
Published: June 30, 2024
The
present
study
aimed
to
develop
and
assess
an
in
situ
gel
formulation
of
Nepafenac
for
treating
ocular
pain
inflammation.
was
created
using
different
polymer
concentrations,
including
Carbopol-940
(0.1%,
0.2%,
0.3%,
0.4%
0.5%
w/v),
HPMC50
(1.5%
HPMC15
(0.6%
w/v)
HPMC5
(0.5%),
as
a
pH-sensitive
gelling
system
enhance
contact
time,
achieve
controlled
release,
reduce
administration
frequency,
improve
therapeutic
efficacy
the
drug.
visual
appearance,
clarity,
melting
point,
pH,
durg
content,
in-situ
gelation
time
were
evaluated
prepared
gels.
Viscosity
solubility
studies
also
conducted.
Results
indicated
that
polymeric
gels
had
transparent
clear
appearance
satisfactory
capacity.
All
optimized
formulations
drug
content
ranging
between
94.29–98.68%.The
demonstrated
pseudoplastic
behavior,
light
yellow
therapeutically
effective,
stable,
released
sustainedly
over
eight
hours.
International Journal of Newgen Research in Pharmacy & Healthcare,
Journal Year:
2024,
Volume and Issue:
unknown, P. 229 - 234
Published: June 30, 2024
This
study
focuses
on
the
design
and
development
of
a
topical
hydrogel
using
Centella
Asiatica
for
treatment
skin
burns.
Asiatica,
well-known
medicinal
plant,
possesses
remarkable
woundhealing
properties,
making
it
promising
candidate
applications.
The
formulation
involved
careful
consideration
concentration
extract
carbopol
940
as
gel-forming
agents
to
achieve
desired
consistency
therapeutic
efficacy.
Characterization
studies
included
evaluation
pH,
viscosity,
spreadability
ensure
optimal
performance
application
research
contributes
growing
body
evidence
supporting
use
in
advanced
wound
care
products.
European Journal of Neuroscience,
Journal Year:
2025,
Volume and Issue:
61(1)
Published: Jan. 1, 2025
Animal
models
have
been
crucial
for
scientific
development,
allowing
researchers
to
understand
the
underlying
mechanisms
of
various
human
conditions,
and
are
far
from
becoming
obsolete
in
research.
However,
ethics
animal
experimentation
has
a
prevalent
question
between
both
experts
nonexperts.
This
essay
tackles
advantages
disadvantages
usage
while
delving
into
new
alternatives
that
emerged
light
contemporary
science.
Drug Discovery Today,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104328 - 104328
Published: March 1, 2025
Sharing
New
Approach
Methodology
(NAM)-based
regulatory
experiences
is
crucial
for
improving
human
risk
assessment
and
reducing
animal
use
in
drug
safety
testing.
To
foster
broader
adoption,
the
Biotechnology
Innovation
Organization
surveyed
companies
about
NAM
usage
collected
case
studies
showcasing
NAM-based
filings
biotherapeutics,
where
NAMs
replaced
large
assessment.
These
scientifically
justified
approaches
were
generally
accepted
by
global
health
authorities,
particularly
context
of
species
relevance
limitations,
prior
target
modulation
experience,
and/or
when
addressing
severe
disease.
Despite
successes
with
filings,
there
are
concerns
from
harmonization
clinical
translatability.
have
potential
greater
uptake
enhanced
guidance
industry-regulatory
agency
collaboration
being
key
to
their
adoption.
