The Possible Role of Postnatal Biphasic Dysregulation of IGF-1 Tone in the Etiology of Idiopathic Autism Spectrum Disorder DOI Open Access

András Visegrády

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4483 - 4483

Published: May 8, 2025

Autism spectrum disorder (ASD) is a pervasive condition of neurodevelopmental origin with an increasing burden on society. Idiopathic ASD notorious for its heterogeneous behavioral manifestations, and despite substantial efforts, etiopathology still unclear. An amount data points to the causative role critical developmental alterations in first year life, although contribution fetal, environmental, genetic factors cannot be clearly distinguished. This review attempts propose narrative starting from neuropathological findings ASD, involving insulin-like growth factor 1 (IGF-1) as key modulator demonstrates how most consistent gestational risk ASD–maternal insulin resistance fetal insufficiency–converge at perinatal dysregulation offspring anabolism period early development. A unifying hypothesis derived, stating that co-occurrence these conditions leads postnatal biphasic IGF-1 tone offspring, leading insulin-dependent accelerated development, then subsequent arrest brain maturation etiologic process. tested explanation various widely reported observations idiopathic including abnormalities, symptoms, familial predisposition, male susceptibility. Finally, further directions research are outlined.

Language: Английский

The potential ameliorative effect of mesenchymal stem cells-derived exosomes on cerebellar histopathology and their modifying role on PI3k-mTOR signaling in rat model of autism spectrum disorder DOI
Raghda Elsherif,

Amel M.M. Abdel-Hafez,

Ola A. Hussein

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(1)

Published: Jan. 6, 2025

Language: Английский

Citations

0
Stem cell therapy for the treatment of psychiatric disorders: a real hope for the next decades DOI Creative Commons
Rosa Villanueva

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

In this review, it is evaluated the progress in application of stem cell therapy to ameliorate symptoms bipolar disorder, major depression, schizophrenia, and autism. These disorders are highly prevalent clinical medicine responsible for high levels psychosocial disability among patients. All them share common biomedical features, such as complex variable genetic substrates, significant susceptibility environmental changes, insufficient knowledge their pathogenesis. addition, responsiveness patients pharmacological treatment heterogeneous, some cases, no available. Therefore, development cell-based regenerative its possible combination with emerging therapeutic approaches that promote neural plasticity expected advance neuropsychiatry next few decades.

Language: Английский

Citations

0
The Possible Role of Postnatal Biphasic Dysregulation of IGF-1 Tone in the Etiology of Idiopathic Autism Spectrum Disorder DOI Open Access

András Visegrády

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4483 - 4483

Published: May 8, 2025

Autism spectrum disorder (ASD) is a pervasive condition of neurodevelopmental origin with an increasing burden on society. Idiopathic ASD notorious for its heterogeneous behavioral manifestations, and despite substantial efforts, etiopathology still unclear. An amount data points to the causative role critical developmental alterations in first year life, although contribution fetal, environmental, genetic factors cannot be clearly distinguished. This review attempts propose narrative starting from neuropathological findings ASD, involving insulin-like growth factor 1 (IGF-1) as key modulator demonstrates how most consistent gestational risk ASD–maternal insulin resistance fetal insufficiency–converge at perinatal dysregulation offspring anabolism period early development. A unifying hypothesis derived, stating that co-occurrence these conditions leads postnatal biphasic IGF-1 tone offspring, leading insulin-dependent accelerated development, then subsequent arrest brain maturation etiologic process. tested explanation various widely reported observations idiopathic including abnormalities, symptoms, familial predisposition, male susceptibility. Finally, further directions research are outlined.

Language: Английский

Citations

0