Neutrophils in Atopic Dermatitis DOI Creative Commons

Chih-Chao Chiang,

Wei-Jen Cheng,

Joseph Renz Marion Santiago Dela Cruz

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Neutrophils have a critical role in inflammation. Recent studies identified their distinctive presence certain types of atopic dermatitis (AD), yet exact function remains unclear. This review aims to compile elucidating the neutrophils AD pathophysiology. Proteins released by neutrophils, including myeloperoxidase, elastase, and lipocalin, contribute pruritus progression AD. Neutrophilic oxidative stress formation neutrophil extracellular traps may further worsen Elevated elastase high-mobility group box 1 protein expression patients' skin exacerbates epidermal barrier defects. Neutrophil-mast cell interactions allergic inflammation steer immunological response toward Th2 imbalance activate Th17 pathway, particularly allergens or infections linked Notably, drugs alleviating pruritic symptoms inhibit neutrophilic In conclusion, these findings underscore that be therapeutic targets for symptoms, emphasizing inclusion treatment strategies.

Language: Английский

Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis DOI Creative Commons
Mengmeng Li,

Jiangyi Wang,

Qingfeng Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 10, 2025

Atopic dermatitis and psoriasis have traditionally been considered distinct inflammatory skin diseases with unique pathogenic mechanisms. However, accumulating evidence suggests significant overlap in their immunological pathways, metabolic features, microbiome characteristics, challenging this conventional dichotomy. This review comprehensively examines the complex relationship between atopic dermatitis, particular emphasis on shared We analyze networks, microbial factors contributing to development progression. The expands upon disease spectrum hypothesis discusses nomenclature for conditions exhibiting features of both diseases. critically evaluate clinical histopathological characteristics concomitant highlighting recent advances molecular diagnostics accurate differentiation. Importantly, we propose standardized diagnostic criteria examine current therapeutic strategies managing overlapping conditions. Recent developments targeted therapies implications treatment selection are thoroughly discussed. By synthesizing identifying knowledge gaps, provides insights into interplay aiming guide decision-making future research directions evolving field.

Language: Английский

Citations

0
Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment DOI
Shuyun Liu, Rui Xin, Xinyue Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by thickening, severe pruritus, lesions, and emotional disturbances, including anxiety depression-like behavior. Current treatments primarily rely on localized therapies, which can lead to adverse effects such as hyperglycemia Cushing's syndrome with repeated use. To address these issues, we developed hyaluronic acid-based separable microneedle patch (Dic@pCu-HA MN), integrating polydopamine-coordinated copper-based metal-organic frameworks (pCu-MOFs) the anti-inflammatory agent dictamnine (Dic), for synergistic management of AD its neuropsychiatric comorbidities. pCu-MOFs exhibited dual functionality nanocargo hydrophobic Dic (encapsulation efficiency: 84.62 ± 2.14%) multienzyme mimics that efficiently scavenge reactive oxygen species (ROS) (superoxide radical scavenging: 63.85 0.34%). In vitro release studies demonstrated ROS-responsive 86.80 4.83% over 48 h under pathology-mimicking conditions. 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced mouse model, Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 7.8% decrease vs control), restored barrier integrity. By modulating HPA axis, system attenuated neuroinflammation alleviated itching (scratching frequency: 40.1 41.3% reduction) behavior (time in bright box: 96.6 156.2% increase). This combined therapeutic approach not only offers comprehensive strategy but also provides potential benefits addressing disorders their sequelae.

Language: Английский

Citations

0
Houttuynia cordata polysaccharides ameliorate atopic dermatitis in mice through modulation of skin immune barrier and lipid metabolism DOI

Rong Huang,

Wenyu Zhang,

Yueqi Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144264 - 144264

Published: May 1, 2025

Language: Английский

Citations

0
Neutrophils in Atopic Dermatitis DOI Creative Commons

Chih-Chao Chiang,

Wei-Jen Cheng,

Joseph Renz Marion Santiago Dela Cruz

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Neutrophils have a critical role in inflammation. Recent studies identified their distinctive presence certain types of atopic dermatitis (AD), yet exact function remains unclear. This review aims to compile elucidating the neutrophils AD pathophysiology. Proteins released by neutrophils, including myeloperoxidase, elastase, and lipocalin, contribute pruritus progression AD. Neutrophilic oxidative stress formation neutrophil extracellular traps may further worsen Elevated elastase high-mobility group box 1 protein expression patients' skin exacerbates epidermal barrier defects. Neutrophil-mast cell interactions allergic inflammation steer immunological response toward Th2 imbalance activate Th17 pathway, particularly allergens or infections linked Notably, drugs alleviating pruritic symptoms inhibit neutrophilic In conclusion, these findings underscore that be therapeutic targets for symptoms, emphasizing inclusion treatment strategies.

Language: Английский

Citations

3