HSP70 Modulators for the Correction of Cognitive, Mnemonic, and Behavioral Disorders After Prenatal Hypoxia

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 982 - 982

Published: April 17, 2025

Background/Objectives: Prenatal hypoxia (PH) is a leading cause of nervous system disorders in early childhood and subsequently leads to decline the cognitive mnemonic functions central (such as memory impairment, reduced learning ability, information processing). It also increases anxiety risk brain adulthood. Compensatory–adaptive mechanisms mother–placenta–fetus system, which enhance fetus’s CNS resilience, are known, including activation endogenous neuroprotection response hypoxic injury through pharmacological modulation HSP70. Methods: To evaluate effect HSP70 modulators—Cerebrocurin, Angiolin, Tamoxifen, Glutaredoxin, Thiotriazoline, HSF-1 (heat shock factor 1 protein), well Mildronate Mexidol—on motor skills, exploratory behaviors, psycho-emotional activities, learning, memories offspring after PH. Experimental PH was induced by daily intraperitoneal injections sodium nitrite solution into pregnant female rats from 16th 21st day pregnancy at dose 50 mg/kg. The newborns received Angiolin (50 mg/kg), Thiotriazoline Mexidol (100 Cerebrocurin (150 µL/kg), L-arginine (200 Glutaredoxin µg/kg), or mg/kg) for 30 days. At month, were tested open field test, 2 months, they trained working spatial radial maze. Results: Modeling led persistent impairments activity, behavior, decrease cognitive–mnestic CNS. found that had most pronounced effects on indicators activity status 1-month-old animals They exhibited significant cognitive-enhancing memory-supporting during training evaluation skill retention maze 2-month-old Conclusions: first time, we obtained experimental data modulators following intrauterine hypoxia. Based results this study, identified agents promising neuroprotective perinatal

Language: Английский

Rest, Repair, Repeat: The Complex Relationship of Autophagy and Sleep

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169227 - 169227

Published: May 1, 2025

Autophagy and sleep are two evolutionary conserved mechanisms across the animal kingdom. is a pathway for degradation of cytoplasmic material in lysosome, playing important roles homeostasis health organism. On other hand, homeostatically regulated state with numerous presumed essential roles, including restoration tissue physiological functions, such as brain waste clearance via activation glymphatic systems. Given that autophagy crucial processes tightly linked to maintenance good health, understanding how they interact great interest, especially quality decreases our modern 24-hour societies. represents promising target therapeutic interventions this context. Here, we review contrasted complementary maintaining homeostasis. Specifically, focus on recent evidence suggesting impairment may increase autophagy, while autophagosome levels modulate amount sleep. We discuss outstanding questions at intersection these fields, highlighting methodological shortcomings current literature. Overcoming limitations will be instrumental design new experiments aim answering one greatest mysteries time - why do sleep?

Language: Английский