Free triiodothyronine levels and age influences the metabolic profile and COVID-19 severity parameters in euthyroid and levothyroxine-treated patients

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 9, 2022

Metabolic reprogramming is required to fight infections and thyroid hormones are key regulators of metabolism. We have analyzed in hospitalized COVID-19 patients: 40 euthyroid 39 levothyroxine (LT4)-treated patients the ward 29 9 LT4-treated intensive care unit (ICU), baseline characteristics, laboratory data, thyroid-stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (FT3), FT3/FT4 ratio, 11 antiviral cytokines 74 metabolomic parameters. No evidence for significant differences between were found biochemical, parameters analyzed. Only TSH (p=0.009) ferritin (p=0.031) showed ward, (p=0.044) FT4 (p=0.012) ICU. Accordingly, severity mortality similar patients. On other hand, FT3 was negatively related age (p=0.012), independently sex body mass index Patients with low older a worse prognosis higher levels markers IL-6 IL-10 than high FT3. correlated (p=0.023) age, sex, whereas positively associated (p=0.035) FT3, sex. A cluster 6 defined Two parameters, esterified cholesterol (p=4.1x10 -4 ) small HDL particles (p=6.0x10 -5 3-hydroxybutyrate (p=0.010), acetone (p=0.076), creatinine (p=0.017) high-density-lipoprotein (HDL) diameter (p=8.3x10 -3 also p-values 0.030, 0.026, 0.017 8.3x10 , respectively. In conclusion, no cytokines, profile, or outcome COVID-19, during hospitalization hypothyroid treated LT4. addition, correlate that predict poor and/or age. indicative ketogenic profile defines non-critical levels.

Language: Английский

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The impact of covid-19 on thyroid function tests in pregnancy

Endocrine, Journal Year: 2022, Volume and Issue: 79(3), P. 502 - 511

Published: Nov. 11, 2022

Language: Английский

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SARS-CoV-2 infection and thyroid dysfunction in children

The Ukrainian Biochemical Journal, Journal Year: 2023, Volume and Issue: 95(3), P. 12 - 21

Published: July 10, 2023

The problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed reveal interrelationship between and COVID-19 severity­ as well determine optimal cut-off values for screening disorders A total number 90 children aged from 1 month 17 years were involved study. Patients with known disease not recruited research. panel was assessed all participants that included: free triiodothyronine (FT3), thyroxine (FT4), thyroid-stimulating hormone (TSH) anti-thyroid peroxidase (ATPO) antibodies. Statistical analysis done using computer software Statistica 13.0. Research has revealed euthyroid sick syndrome (ESS) 14.10% infected more often among patients severe multisystem inflammatory (33.33%) compared mild course (6.67%) moderate severity (8.89%) (P < 0.05). Significant correlation relationships next – FT3 erythrocyte sedimentation rate (ESR) (rs = -0.22; P 0.05); C-reactive protein (CRP) -0.33; procalcitonin -0.43; ESS determination revealed: ESR 18.5 mm/h (AUC 0.803); CRP 11.5 mg/l 0.763); ferritin 84.8 ng/ml 0.733). Results suggest pediatricians should pay attention endocrine disruptions by Keywords: COVID-19, children, markers

Language: Английский

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Clinical Features and Functional State of the Adrenal Cortex and Thyroid Gland in Children with Covid-19 during the Recovery Period

Journal of Advances in Medicine and Medical Research, Journal Year: 2024, Volume and Issue: 36(2), P. 113 - 124

Published: Feb. 16, 2024

The available literature provides limited data on the demographic and clinical features of SARS-CoV-2 infection in children. This information is especially important because pneumonia single leading cause death children worldwide. Research this direction particularly to clarify better understand global impact COVID-19 pediatric population. Unlike adults, most infected have a milder course results overall. article also an analysis violation functional state adrenal cortex thyroid gland children, laboratory biochemical changes based study history disease receiving treatment for coronavirus infection. At same time, level thyroid-stimulating hormone, total T3, T4 cortisol who had was assessed. last stage demonstrates prevention rehabilitation after

Language: Английский

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Late post-COVID syndrome: clinical complications beyong 12 weeks

Journal of Clinical Medicine of Kazakhstan, Journal Year: 2024, Volume and Issue: 21(1), P. 9 - 13

Published: Feb. 25, 2024

The persistent and diverse manifestations of post-COVID syndrome present a significant challenge for global healthcare. Beyond the acute phase infection, individuals continue to grapple with lingering symptoms affecting various organ systems, including respiratory, cardiovascular, neurological, endocrine systems. In respiratory realm, such as cough, dyspnea, fatigue endure, particularly in those history severe COVID-19. cardiovascular impact manifests chest pain, arrhythmias, heightened risks thromboembolic events, emphasizing intricate connection between COVID-19 complications. Neurological complications, ranging from headaches more disorders, further contribute complex sequelae syndrome. Additionally, disruptions system, new-onset diabetes thyroid abnormalities, pose long-term challenges affected individuals. review discusses clinical management posed by multifaceted nature complications necessity tailored multidisciplinary approaches. A holistic compassionate response effects requires collaboration across healthcare professionals, researchers broader community. By navigating these collectively, we can pave way comprehensive effective approach care.

Language: Английский

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