Clinical features and long-term survival in idiopathic pulmonary arterial hypertension with thyroid dysfunction: insights from a national multicentre prospective study DOI Creative Commons
Yuling Qian, Ruilin Quan, Xiaoxi Chen

et al.

ERJ Open Research, Journal Year: 2023, Volume and Issue: 9(6), P. 00495 - 2023

Published: Oct. 12, 2023

Background Our objective was to clarify the characteristics and long-term survival of idiopathic pulmonary arterial hypertension (IPAH) patients with thyroid dysfunction compare them IPAH without dysfunction. Methods A retrospective analysis conducted using prospectively collected data. at baseline were included. Patients other subgroups PAH Group 2–5 excluded. euthyroid function matched 1:1 by age sex. Results In total, 148 hyperthyroidism, hypothyroidism, subclinical hyperthyroidism hypothyroidism accounted for 16.2%, 18.9%, 8.1% 56.8%, respectively. showed highest mixed venous oxygen saturation ( S vO 2 ) lowest vascular resistance (PVR) among subgroups, while had PVR (p<0.05). Compared dysfunction, (9.14 versus 13.86 WU; p<0.05) (10.70 significantly lower PVR. The haemodynamic profiles similar except right atrial pressure (6 8 mmHg; p=0.009). clinical better than that those diseases comparable latter, even after adjusting haemodynamics treatment. Conclusion hyper- latter.

Language: Английский

Clinical features and long-term survival in idiopathic pulmonary arterial hypertension with thyroid dysfunction: insights from a national multicentre prospective study DOI Creative Commons
Yuling Qian, Ruilin Quan, Xiaoxi Chen

et al.

ERJ Open Research, Journal Year: 2023, Volume and Issue: 9(6), P. 00495 - 2023

Published: Oct. 12, 2023

Background Our objective was to clarify the characteristics and long-term survival of idiopathic pulmonary arterial hypertension (IPAH) patients with thyroid dysfunction compare them IPAH without dysfunction. Methods A retrospective analysis conducted using prospectively collected data. at baseline were included. Patients other subgroups PAH Group 2–5 excluded. euthyroid function matched 1:1 by age sex. Results In total, 148 hyperthyroidism, hypothyroidism, subclinical hyperthyroidism hypothyroidism accounted for 16.2%, 18.9%, 8.1% 56.8%, respectively. showed highest mixed venous oxygen saturation ( S vO 2 ) lowest vascular resistance (PVR) among subgroups, while had PVR (p<0.05). Compared dysfunction, (9.14 versus 13.86 WU; p<0.05) (10.70 significantly lower PVR. The haemodynamic profiles similar except right atrial pressure (6 8 mmHg; p=0.009). clinical better than that those diseases comparable latter, even after adjusting haemodynamics treatment. Conclusion hyper- latter.

Language: Английский

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