Exploring the Effects of Vitamin D and Vitamin A Levels on the Response to COVID-19 Vaccine

Vaccines, Journal Year: 2023, Volume and Issue: 11(9), P. 1509 - 1509

Published: Sept. 21, 2023

COVID-19 vaccines were developed at an unprecedented speed in history. The factors affecting the response to are not clear. Herein, effects of vitamin D and A (retinol) levels on BNT162b2 vaccine explored. total 124 recipients recruited from general population attending vaccination centers Irbid, Jordan. Blood samples collected immediately before receiving first dose (D0) three weeks later (D21). Baseline 25-hydroxyvitamin [25(OH)D], retinol, SARS-CoV-2 S1 IgG antibodies measured with ELISA. was tested by measuring avidity D21. participants divided into two groups, unexposed exposed, based D0 antibody results. No significant correlation found between 25(OH)D or retinol levels, avidity, fold increase both groups. Similarly, no difference status combined These findings show that baseline have effect short-term a single vaccine.

Language: Английский

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Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 25, 2024

Objectives Vitamin D has a role in the innate immunity against pathogens and is also involved mechanisms for reducing inflammation. VD deficiency (VDD) may increase COVID-19 infection susceptibility, however research limited on association between VDD symptom prevalence duration. The study aimed to determine whether risk factor presence extended duration of symptoms. Methods Data was analyzed from NHS healthcare workers who isolated due symptoms as part convalescent 12th 22nd May 2020. Participants self-reported viral Anti-SARS-CoV-2 antibodies vitamin (25(OH)D 3 ) serum levels were measured day recruitment. defined 25(OH)D < 30 nmol/l. Results Of 392 participants, 15.6% ( n = 61) had VDD. participants more overall p 0.0030), including body aches 0.0453), 0.0075) fatigue 0.0127). Binary logistic regression found that both (OR 3.069, 95% CI 1.538–6.124; 0.001) age 1.026, 1.003–1.049; 0.025) independently associated with durations aches. 2.089, 1.087–4.011; 0.027), 1.036, 1.016–1.057; seroconversion 1.917, 1.203–3.056; 0.006), fatigue. Conclusion significant independent supplementation reduce thus an area future research.

Language: Английский

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Long-Term Assessment of Antibody Response to COVID-19 Vaccination in People with Cystic Fibrosis and Solid Organ Transplantation

Vaccines, Journal Year: 2024, Volume and Issue: 12(1), P. 98 - 98

Published: Jan. 18, 2024

With the worldwide spread of SARS-CoV-2 disease, people with cystic fibrosis (CF), especially solid organ transplant recipients, have quickly been identified as a risk group for severe disease. Studies shown low antibody response to vaccines in recipients compared healthy population. Information on immune CF patients transplantation is limited, regarding long-term efficacy. The aim this real-world study was assessment humoral induced by three and four doses mRNA vaccine. S1RBD IgG antibodies were measured every 12 weeks over period 27 months twelve (five liver seven lung recipients). A total 83.3% our showed positive after sustained observed both groups observation period, showing higher levels than recipients. This among first show data constantly elevated or even increasing levels. We conclude that effect most likely associated repeated boostering terms infections booster vaccinations.

Language: Английский

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Vitamin D Supplementation and Prior Oral Poliovirus Vaccination Decrease Odds of COVID-19 Outcomes among Adults Recently Inoculated with Inactivated Poliovirus Vaccine

Vaccines, Journal Year: 2024, Volume and Issue: 12(2), P. 121 - 121

Published: Jan. 24, 2024

Background: Structural and functional commonalities between poliovirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suggest that inoculation may induce antibodies mitigate the disease (COVID-19). No known studies have evaluated COVID-19 risk factors in adults recently vaccinated against poliovirus. Study Objective: Among with no history of infection or vaccination, who received an inactivated vaccine (IPV), we sought to determine which biological social determinants health (SDOH) be associated (1) testing positive for SARS-CoV-2, (2) experiencing symptoms, (3) a longer duration symptoms. Methods: The influence SDOH on SARS-CoV-2 symptoms were among 282 inoculated IPV. Participant-reported surveys analyzed over 12 months post-enrollment. Bivariate multivariate linear logistic regression models identified associations variables outcomes. Results: Adjusting vaccinations, variants, other SDOH, secondary analyses revealed underlying conditions, employment, vitamin D, education, oral vaccination (OPV) odds significantly reduced participants took D (OR 0.12 OR 0.09, respectively). Unemployed part-time working 72% less likely test compared full-time workers. prior dose OPV was one strongest predictors 4.36) 6.95). Conclusions: Findings prophylactic measures mucosal immunity severity Larger-scale inform future policies.

Language: Английский

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The association between vitamin D deficiency and the clinical outcomes of hospitalized COVID-19 patients

F1000Research, Journal Year: 2024, Volume and Issue: 12, P. 394 - 394

Published: Feb. 5, 2024

Background Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, role vitamin COVID-19 infection remains controversial. This study aimed analyze association on clinical outcome hospitalized patients. Methods A prospective cohort was conducted among patients at two referral hospitals Indonesia from October 2021 until February 2022. Results The median serum 25(OH)D level 191 13.6 [IQR=10.98] ng/mL. levels were significantly lower with who had cardiovascular disease (p-value=0.04), use a ventilator (p-value=0.004), severe cases (p-value=0.047), mortality (p-value=0.002). Furthermore, different between mild (p-value=0.019). Serum moderate (p-value=0.031). Lower associated increased number comorbidities (p-value=0.03), (p-value=0.002), mechanical ventilation (p-value=0.032). Mortality found 7.3% deficient levels. either sufficient or insufficient did not develop mortality. Conclusions having disease, mortality, cases, used ventilation. comorbidities, severity, mechanical-ventilation. Thus, we suggest reach status improve disease.

Language: Английский

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Therapeutic role of vitamin D in COVID-19 patients

Clinical Nutrition Open Science, Journal Year: 2024, Volume and Issue: 57, P. 78 - 87

Published: July 16, 2024

SARS-CoV-2 has had a significant worldwide impact, leading to widespread illness and mortality. With the lack of specific antiviral treatments, there is growing interest in exploring potential therapeutic effects various nutritional supplements, including vitamin D. Vitamin D plays an essential role health, been implicated modulating immune response reducing inflammation, which may have implications prevention management coronavirus disease 2019 (COVID-19). Patients having low level are predisposed severe consequences. COVID-19 shown inverse relationship. This review understanding remedial COVID-19, its mechanism action, evidence from clinical studies, recommendations for supplementation patients suffering COVID-19.Material MethodsGoogle scholar, Sci-Hub, pubmed.

Language: Английский

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