The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats DOI Open Access

Sukayna Hussain Rashed,

Saba Z. Al-Abachi,

Raghad Hamoo

et al.

Egyptian Journal of Veterinary Science, Journal Year: 2024, Volume and Issue: 56(2), P. 257 - 271

Published: May 8, 2024

Human and animal anovulation is a result of polysystolic ovary PCOS which involves endocrine, reproductive, metabolic abnormalities. Finding new medications with least amount toxicity major scientific challenge. The study's goal to assess biochemical variables in blood serum heart tissue female rats as models androgen-induced the impact oxidative stress development cardiovascular characteristics resulting from PCOS. PCOS-induced were treated liquorice root [L.], green tea [GT], marjoram [M.] extracts at 150, 250 100 mg Kg−1 B.W. respectively. Metformin [Met.] 20 kg−1 used standard medication. study employed 36 aged 8-10 weeks. Six [n=6] groups formed. At zero time end trial, was obtained all estimate total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C, glucose, protein, CRP, glutathione, malondialdehyde, glutathione peroxidase, AST, ALT, ALP, testosterone, estradiol, progesterone CK, LDH, IL-1β TNF-α tissue. In androgen, there has been rise measured parameters except progesterone, GSH, GSH-Px and, increased again three extracts-treated groups. M. extract more active than GT L. improvement [CV] parameters. Since LDH regained normal values. conclusion, demonstrated that M., GT, can decrease negative effects particular on features, treating these herbs recommended.

Language: Английский

ApoB100 and Atherosclerosis: What’s New in the 21st Century? DOI Creative Commons
Dimitris Kounatidis, Natalia G. Vallianou, Aikaterini Poulaki

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(2), P. 123 - 123

Published: Feb. 12, 2024

ApoB is the main protein of triglyceride-rich lipoproteins and further divided into ApoB48 in intestine ApoB100 liver. Very low-density lipoprotein (VLDL) produced by liver, contains ApoB100, metabolized its remnants, intermediate-density (IDL) (LDL). has been suggested to play a crucial role formation atherogenic plaque. Apart from being biomarker atherosclerosis, seems be implicated inflammatory process atherosclerosis per se. In this review, we will focus on structure, metabolism, function as well predictor cardiovascular risk. Moreover, elaborate upon molecular mechanisms regarding pathophysiology discuss disorders associated with APOB gene mutations, potential various drugs therapeutic targets.

Language: Английский

Citations

15
Adipose-derived extracellular vesicles – a novel cross-talk mechanism in insulin resistance, non-alcoholic fatty liver disease, and polycystic ovary syndrome DOI
Dušan Mladenović, Milena Vesković, Nikola Šutulović

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 85(1), P. 18 - 34

Published: Jan. 29, 2024

Language: Английский

Citations

14
The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats DOI Open Access

Sukayna Hussain Rashed,

Saba Z. Al-Abachi,

Raghad Hamoo

et al.

Egyptian Journal of Veterinary Science, Journal Year: 2024, Volume and Issue: 56(2), P. 257 - 271

Published: May 8, 2024

Human and animal anovulation is a result of polysystolic ovary PCOS which involves endocrine, reproductive, metabolic abnormalities. Finding new medications with least amount toxicity major scientific challenge. The study's goal to assess biochemical variables in blood serum heart tissue female rats as models androgen-induced the impact oxidative stress development cardiovascular characteristics resulting from PCOS. PCOS-induced were treated liquorice root [L.], green tea [GT], marjoram [M.] extracts at 150, 250 100 mg Kg−1 B.W. respectively. Metformin [Met.] 20 kg−1 used standard medication. study employed 36 aged 8-10 weeks. Six [n=6] groups formed. At zero time end trial, was obtained all estimate total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C, glucose, protein, CRP, glutathione, malondialdehyde, glutathione peroxidase, AST, ALT, ALP, testosterone, estradiol, progesterone CK, LDH, IL-1β TNF-α tissue. In androgen, there has been rise measured parameters except progesterone, GSH, GSH-Px and, increased again three extracts-treated groups. M. extract more active than GT L. improvement [CV] parameters. Since LDH regained normal values. conclusion, demonstrated that M., GT, can decrease negative effects particular on features, treating these herbs recommended.

Language: Английский

Citations

0