FSH/LH co-stimulation in Advanced Maternal Age (AMA) and hypo-responder patients – Arabian gulf delphi consensus group DOI Creative Commons
Johnny Awwad, Braulio Peramo,

Bohaira Elgeyoushi

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Background In a global effort to assess expert perspectives on the use of recombinant gonadotropins, human luteinizing hormone (r-hLH) and follicle-stimulating (r-hFSH), consensus meeting was held in Dubai. The key aim address three critical questions: What are factors that influence follicle response gonadotropins? Which categories patients most likely benefit from LH supplementation? And what optimal management strategies for these patients? Methods A panel thirty-six experts reviewed refined initial statements references proposed by Scientific Coordinator. Consensus defined as agreement or disagreement more than two-thirds (66%) members each statement. Results Thirty-five were formulated, which thirty-one reached consensus. For with Hypo-Response Gonadotropin Stimulation (20 statements), all identified risk factors, including advanced age, high BMI, chronic conditions, achieved unanimous agreement. Diagnostic approaches, such inclusion POSEIDON criteria level monitoring, endorsed majority, over 90% Management strategies, particularly individualized stimulation protocols optimized scheduling, garnered broad consensus, only one statement falling short threshold. Additionally, cases severe FSH deficiency, combining r-hFSH r-hLH found improve pregnancy rates cost efficiency compared menopausal gonadotropin (hMG). Advanced Maternal Age (AMA) (15 there strong oral contraceptive pills estrogen priming. Recommendations concerning antagonist dosing also levels Significant supported supplementation tailored approach luteal phase support. However, mixed opinions route progesterone administration, some expressing neutral disagreeing views. Despite differences, markers treatment success, live birth rates, embryo development, underscoring importance outcomes evaluating efficacy. Conclusion This provides practical clinical perspective wide range professionals employed during phases Assisted Reproductive Technology (ART) treatment. To further outcomes, incorporating additional insights ART alongside existing guidelines policies, may offer valuable guidance optimizing patient care.

Language: Английский

Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 DOI Creative Commons
Jeff J. Guo, Zhen Liu, Pengjun Wang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 15, 2025

Chronic kidney disease (CKD) is a significant global health issue, often linked to diabetes, hypertension, and glomerulonephritis. However, aggregated statistics can obscure heterogeneity across subtypes, age, gender, regions. This study aimed analyze CKD trends from 1990 2021, focusing on socio-demographic index (SDI), regional variations. Data were extracted the Global Burden of Disease (GBD) 2021 database, covering prevalence, incidence, mortality, disability-adjusted life years (DALYs). These presented as counts per 100,000 population age-standardized rates, with uncertainty intervals (UIs) highlight variability. Joinpoint regression was used assess over 30-year period. In prevalence 359 million, 11.13 million new cases, 1.53 deaths, 44.45 DALYs-up 92, 156, 176, 114% since 1990. While slightly declined, DALYs increased significantly. burden varied by region notable gender disparities. The highlights dramatic rise in growth aging, emphasizing need for targeted treatment effective healthcare policies.

Language: Английский

Citations

3
Association between a body shape index and female infertility: a cross-sectional study DOI Creative Commons
Qian Yang,

Jianxiong Wuliu,

Lingling Zeng

et al.

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 4, 2024

Language: Английский

Citations

4
Analysis of hormonal status and the course of endometriosis in patients with type 1 diabetes mellitus DOI

Elena V. Misharina,

Alena V. Tiselko, Maria I. Yarmolinskaya

et al.

Journal of obstetrics and women s diseases, Journal Year: 2025, Volume and Issue: 73(6), P. 101 - 115

Published: Jan. 30, 2025

Background: Type 1 diabetes mellitus and endometriosis significantly reduce the quality of patient’s life hinder implementation reproductive plans. Studying features clinical course in patients with type will help development new effective safe therapeutic strategies diagnostic methods. Aim: The aim this study was to analyze diseases, hormonal status blood vitamin D (25-hydroxycalciferol) levels combined endometriosis. Materials methods: This prospective included 339 women, whom 79 were (mean age 31.7 ± 5.0 years), 51 31.4 3.7 209 30.2 4.9 years). control group consisted 31 healthy women age. immunochemiluminescent method used determine serum anti-Müllerian hormone, follicle-stimulating luteinizing prolactin, estradiol (days 2–5 menstrual cycle), progesterone 20–23 cycle) during three consecutive cycles, level glycated hemoglobin also studied mellitus. diagnosis all confirmed based on laparoscopic surgery verification by histological examination. Results: When assessing gonadotropins, hormone endometriosis, a decrease noted comparison other groups. gonadotropins prolactin groups comparable. In groups, days cycle lower than group. concentration patients’ peripheral compared group, minimum value 16.3 4.1 ng/ml found those disease no differences between onset its duration, total daily insulin dose, dose per kilogram weight. higher distributing grades prevalence, it that III IV more common without incidence deep infiltrating only, as number reoperations. Conclusions: asymptomatic preclinical period may lead untimely erroneous delayed treatment disease. puberty suffering from risk vascular complications increases ovarian reserve decreases, which requires goals early possible. choosing therapy for mellitus, presence should be taken into account.

Language: Английский

Citations

0
Multilevel Assessment of Glycemic, Hormonal, and Oxidative Parameters in an Experimental Diabetic Female Rat Model DOI Creative Commons

Iulian Tătaru,

Ioannis Gardikiotis,

Oana-Maria Dragostin

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 922 - 922

Published: April 9, 2025

Background: Diabetes mellitus induces profound metabolic and endocrine alterations, impacting reproductive function through oxidative stress hormonal imbalances. This study investigated the effects of alloxan-induced diabetes on status in female Wistar rats. Methods: A synthetic sulfonamide derivative (compound S) was obtained via chemical synthesis characterized by elemental spectral analysis. Salvia officinalis extract phytochemically profiled using UHPLC-HRMS assessed for antioxidant potential DPPH, ABTS, FRAP assays. The compound plant extract, along with metformin were evaluated vivo their antihyperglycemic, hormone-regulating, properties., Serum levels progesterone, estradiol, follicle-stimulating hormone (FSH) alongside biomarkers transforming growth factor-beta 1 (TGF-β1) glutathione peroxidase 3 (GPX3). Results: Diabetic rats (untreated) exhibited a significant decrease estradiol (22.00 ± 4.1 pg/mL vs. 54.74 17.5 controls, p < 0.001) an increase progesterone (17.38 9.6 ng/mL 3.59 0.90 0.05), suggestive ovarian dysfunction. TGF-β1 elevated diabetic (27.73 19.4 21.55 13.15 while increased serum GPX3 (61.50 11.3 38.20 12.84 0.05) indicates enhanced stress. Statistical analysis revealed correlation between levels, FSH (p = −0.039), −0.025) group (L2). Conclusions: These findings contribute new evidence regarding hormones models.

Language: Английский

Citations

0
Association of ambient ozone with time to pregnancy and the modifying effect of ambient temperature: a population-based cohort study DOI

Bingxue Wu,

Tao Wang, Yan Zhang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126269 - 126269

Published: April 1, 2025

Language: Английский

Citations

0
Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity DOI Creative Commons
Laura Franza, Mario Caldarelli, Emanuele Rocco Villani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1645 - 1645

Published: July 24, 2024

Cardiovascular diseases (CVDs) are the most common cause of mortality and morbidity in Western countries, thus representing a global health concern. CVDs show different patterns terms prevalence presentation men women. The role sex hormones has been extensively implicated these sex-specific differences, due to presence menstrual cycle menopause Moreover, gut microbiota (GM) cardiovascular health, considering growing evidence that it is involved determining development specific diseases. In particular, gut-derived metabolites have linked kidney disorders, which can turn promote progression CVDs. Considering differences composition GM between women, possible act as mediator regard disparities This narrative review aims comprehensively interplay sex, GM, CVDs, discussing potential mechanisms therapeutic options.

Language: Английский

Citations

1
The Impact of HbA1C level on FSH and LH Changes during menopausal Transition in Diabetes Women DOI Open Access

Ahmed L. Hamad,

Ghufran S. Jawad,

Marwa A. Hadi

et al.

International Journal of Medical Science and Dental Health, Journal Year: 2024, Volume and Issue: 10(07), P. 48 - 54

Published: July 29, 2024

Diabetes mellitus (DM) is a prevalent endocrine disorder characterized by prolonged elevation of blood glucose levels. Hemoglobin A1c (HbA1c) serves as critical metric for assessing mean glycemic control in individuals with diabetes. In this study, we aimed to explore the impact diabetic control, measured HbA1c levels, on pituitary gonadotropins (FSH and LH) Iraqi women Type 2 diabetes during menopausal transition. A cross-sectional study involving one hundred aged between 45 60 years was conducted from November 2023 March 2024. Participants were categorized into groups based values indicating good or poor control. Data various variables including age, height, weight, BMI, fasting sugar, HbA1c, FSH, LH collected analyzed. Our findings revealed no significant difference FSH levels among varying degrees Spearman's rho correlation coefficients showed weak negative correlations both These results underscore complex interplay hormonal regulation, metabolic factors

Language: Английский

Citations

0
Association Between NsiI and PmLI Insulin Receptors on the Development of Polycystic Ovarian Syndrome DOI Open Access

Walaa Talal Abdul-Late,

Mushtak T.S. Al-Ouqaili, Rafal Mustafa Murshid

et al.

Pakistan Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 27(11), P. 526 - 536

Published: Oct. 15, 2024

<b>Background and Objective:</b> Polycystic Ovarian Syndrome (PCOS) is a hormonal abnormality that influences the age during reproduction. This investigation aimed to identify impact of insulin receptor-encoding genes (NsiI PmLI) on development PCOS their effect HOMA-IR levels. <b>Materials Methods:</b> The study included 80 patients 25 healthy individuals. concentrations HOMA-IR, fasting blood sugar hormone were determined. PCR-RFLP was applied receptors in NsiI PmLI SNPs. Sanger sequencing used for each these patients. data analyzed using SPSS version 16.0 χ<sup>2</sup> test p<0.05 considered statistically significant. Also, Hardy-Weinberg equilibrium genotype frequencies used. <b>Results:</b> mean levels significantly differed between control subjects females ("p = 0.002 "p 0.000, correspondingly). Concerning odds ratio frequency polymorphisms heterozygote A/G homozygote mutant G/G groups greater than individual (OR 1.14, p>0.05) 5.20, p>0.05). However, polymorphism, CC TT linked with pathogenic effects susceptibility 1.83, 12.07, CT protective factor 0.22, p<0.05). <b>Conclusion:</b> A strong relationship high as well elevated has been found women PCOS. Furthermore, INSR gene may be molecular marker associated decreased sensitivity

Language: Английский

Citations

0
FSH/LH co-stimulation in Advanced Maternal Age (AMA) and hypo-responder patients – Arabian gulf delphi consensus group DOI Creative Commons
Johnny Awwad, Braulio Peramo,

Bohaira Elgeyoushi

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Background In a global effort to assess expert perspectives on the use of recombinant gonadotropins, human luteinizing hormone (r-hLH) and follicle-stimulating (r-hFSH), consensus meeting was held in Dubai. The key aim address three critical questions: What are factors that influence follicle response gonadotropins? Which categories patients most likely benefit from LH supplementation? And what optimal management strategies for these patients? Methods A panel thirty-six experts reviewed refined initial statements references proposed by Scientific Coordinator. Consensus defined as agreement or disagreement more than two-thirds (66%) members each statement. Results Thirty-five were formulated, which thirty-one reached consensus. For with Hypo-Response Gonadotropin Stimulation (20 statements), all identified risk factors, including advanced age, high BMI, chronic conditions, achieved unanimous agreement. Diagnostic approaches, such inclusion POSEIDON criteria level monitoring, endorsed majority, over 90% Management strategies, particularly individualized stimulation protocols optimized scheduling, garnered broad consensus, only one statement falling short threshold. Additionally, cases severe FSH deficiency, combining r-hFSH r-hLH found improve pregnancy rates cost efficiency compared menopausal gonadotropin (hMG). Advanced Maternal Age (AMA) (15 there strong oral contraceptive pills estrogen priming. Recommendations concerning antagonist dosing also levels Significant supported supplementation tailored approach luteal phase support. However, mixed opinions route progesterone administration, some expressing neutral disagreeing views. Despite differences, markers treatment success, live birth rates, embryo development, underscoring importance outcomes evaluating efficacy. Conclusion This provides practical clinical perspective wide range professionals employed during phases Assisted Reproductive Technology (ART) treatment. To further outcomes, incorporating additional insights ART alongside existing guidelines policies, may offer valuable guidance optimizing patient care.

Language: Английский

Citations

0