Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex

Livers, Journal Year: 2024, Volume and Issue: 4(4), P. 534 - 549

Published: Oct. 17, 2024

Hepatic steatosis is considered the hepatic manifestation of metabolic disorders. Its global prevalence a growing public health concern, estimated to affect over 30% population. Steatosis strictly linked dysfunction, leading revised terminology MASLD (metabolic dysfunction-associated steatotic liver disease). The disease often progresses in conjunction with syndrome components, significantly increasing cardiovascular and overall mortality risks. interplay between sex hormones dysfunction crucial, male hypogonadism female hyperandrogenism exacerbating risk severity steatosis. In men, testosterone deficiency associated increased visceral adiposity insulin resistance, creating vicious cycle deterioration. Conversely, women, hyperandrogenism, particularly conditions like polycystic ovary syndrome, may lead severe disturbances, including Estrogen also contributes central syndrome. aim this paper discuss complex sex-dimorphic relationship.

Language: Английский

Genistein mitigates diet-induced obesity and metabolic dysfunctions in gonadectomized mice with some sex-differential effects

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Background Obesity is associated with insulin resistance (IR) and metabolic dysfunction-associated steatotic liver disease (MASLD). Genistein, an isoflavone, a promising natural compound for preventing treating obesity dysfunctions. We aimed to investigate the sex-specific protective effects of genistein on obesity, IR, MASLD in murine model sex hormone deprivation diet-induced (DIO), mimicking postmenopausal women or aging men syndrome. Methods Gonadectomized sham-operated C57BL/6NJcl mice were fed high-fat high-sucrose diet 4 weeks induce (7 per group). In gonadectomized mice, (16 mg/kg/day) vehicle (7.5% dimethyl sulfoxide) was orally administered 45 days. assessed glucose homeostasis parameters, hepatic histopathology, gene expression gonadectomy treatment. Results Gonadectomy exacerbated adiposity both sexes. Ovariectomy diminished female gonadal hormones homeostatic assessment (HOMA-IR), serum alanine transaminase levels, steatosis score, genes progression such as Fasn , Srebf1 Saa1 Cd36 Col1a1 Pck1 Ppargc1a . Genistein treatment significantly reduced body weight gain score However, attenuated HOMA-IR only mice. Conclusion mitigates DIO-related male Regarding beneficial effect evident This study suggests potential alternative application individuals deprivation, yet pending clinical trials.

Language: Английский

Sex differences in the metabolic activation of and platelet response to vicagrel in mice: Androgen as a key player

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116564 - 116564

Published: Oct. 1, 2024

Language: Английский