Vitamin D supplementation for managing COVID-19 in patients with vitamin D deficiency: a systematic review and meta-analysis of randomised controlled trials

BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e091903 - e091903

Published: March 1, 2025

Objectives Vitamin D deficiency is prevalent among the population. Previous studies have shown that vitamin supplementation might be useful for treating COVID-19 infection. Therefore, we performed a meta-analysis to explore efficacy in patients with deficiency. Design Systematic review and Data sources PubMed, Cochrane Library, Embase Web of Science. Eligibility criteria Randomised controlled trials exploring extraction synthesis Two independent reviewers employed standardised methods search, screen code included studies. The primary outcomes mortality during follow-up, 28-day mortality, need mechanical ventilation intensive care unit (ICU). secondary outcome length stay hospital ICU. risk bias was assessed using Risk Bias 2 tool. Depending on level heterogeneity, either random-effects model or fixed-effects applied. findings were summarised Grading Recommendations Assessment, Development Evaluation (GRADE) evidence profiles synthesised qualitatively. Results A total nine studies, comprising 870 participants, analysis. pooled results indicated associated lower (risk ratio 0.76; 95% CI 0.60 0.97). However, this apparent benefit not robust when examined through leave-one-out method trial sequential Regarding other outcomes, there no statistically significant difference between terms ICU admission. 0.41 day shorter (mean −0.41; −1.09 0.28) 0.07 −0.07; −0.61 0.46) compared supplementation; however, neither significant. Conclusion Based low moderate quality, reduced rate follow-up it did improve nor reduce admission, hospital. PROSPERO registration number CRD42024573791.

Language: Английский

Therapeutic role of vitamin D in COVID-19 patients

Clinical Nutrition Open Science, Journal Year: 2024, Volume and Issue: 57, P. 78 - 87

Published: July 16, 2024

SARS-CoV-2 has had a significant worldwide impact, leading to widespread illness and mortality. With the lack of specific antiviral treatments, there is growing interest in exploring potential therapeutic effects various nutritional supplements, including vitamin D. Vitamin D plays an essential role health, been implicated modulating immune response reducing inflammation, which may have implications prevention management coronavirus disease 2019 (COVID-19). Patients having low level are predisposed severe consequences. COVID-19 shown inverse relationship. This review understanding remedial COVID-19, its mechanism action, evidence from clinical studies, recommendations for supplementation patients suffering COVID-19.Material MethodsGoogle scholar, Sci-Hub, pubmed.

Language: Английский