Cancer Cytopathology, Journal Year: 2024, Volume and Issue: 132(8), P. 525 - 536
Published: June 14, 2024
Abstract Background Differentiated high‐grade thyroid carcinoma (DHGTC) is recently recognized by the World Health Organization (WHO) as a subgroup of carcinomas with features while retaining architectural and/or cytologic well‐differentiated follicular–cell‐derived tumors. The cytomorphology DHGTC not well documented despite potential implications for patient triage and management. Methods pathology archives six institutions were searched cases diagnosed on resection “high‐grade carcinoma” using WHO criteria. fine‐needle aspiration (FNA) cohort represents 10‐year period (2013–2023); all reviewed to confirm classification. corresponding FNAs assessed 32 cytomorphologic features. Results Forty prior FNA identified. mean age was 64.2 years. average lesion size 4.9 cm, majority demonstrated TI‐RADS score 4 or 5 (95.2%). Three main subsets based histology included papillary (65%), follicular (22.5%), oncocytic (12.5%). Over 97% classified Bethesda category IV above. Approximately 25% showed that marked atypia, increased anisonucleosis, large oval nuclei, mitotic activity, necrosis ( p < .05); 68% associated high‐risk molecular alterations. TERT mutations occurred in 41%, which 89% these second mutation, usually RAS BRAF .V600E. Conclusions Cytology has low sensitivity DHGTC, although subset DHGTCs have raising possibility carcinoma. Other findings include changes clinicopathologic such older larger size.
Language: Английский
Citations
4A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma
Current Oncology, Journal Year: 2024, Volume and Issue: 31(6), P. 3311 - 3328
Published: June 9, 2024
Differentiated high-grade thyroid carcinoma (DHGTC) is a new subset within the spectrum of malignancies. This review aims to provide comprehensive overview DHGTC, focusing on its historical perspective, diagnosis, clinical characteristics, molecular profiles, management, and prognosis. DHGTC demonstrates an intermediate prognosis that falls between well-differentiated anaplastic carcinoma. Previously unenumerated, this entity now recognized for significant impact. Patients with often present at older age advanced disease exhibit aggressive behavior. Molecularly, shares similarities other malignancies, harboring driver mutations such as BRAFV600E RAS, along additional late mutations. The unique behavior histologic features underscore necessity precise classification prognostication treatment selection. highlights critical importance accurate diagnosis recognition by pathologists enrich future research further.
Language: Английский
Citations
3Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact
Virchows Archiv, Journal Year: 2024, Volume and Issue: 484(5), P. 733 - 742
Published: Feb. 24, 2024
Language: Английский
Citations
2Columnar Cell Thyroid Carcinoma: A Heterogeneous Entity Demonstrating Overlap Between Papillary Thyroid Carcinoma and Follicular Neoplasms
Head and Neck Pathology, Journal Year: 2024, Volume and Issue: 18(1)
Published: May 10, 2024
Language: Английский
Citations
2The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(6), P. 654 - 654
Published: June 18, 2024
Background: Poorly differentiated thyroid carcinoma (PDTC) has an intermediate prognosis between indolent well-differentiated (TC) and anaplastic carcinoma. Herein, we present a case report with PDTC component, along systematic review of the literature. Case Report: We 45-year-old man diagnosed hobnail tall-cell variant features positive for BRAFV600E mutation, after total thyroidectomy neck dissection. Radioactive iodine (RAI)-131 therapy was applied, but early recurrence led to complementary surgeries. The anti-Tg rise, presence new lymph nodes, negative whole-bodyradioiodine scan were suggestive radioiodine-resistant tumor. Lenvatinib, sorafenib, dabrafenib/trametinib, cabozantinib radiotherapy all administered, controlling tumor period time before patient ultimately died post-COVID infection. Systematic Review: searched PubMed, Scopus, WebofScience identify studies reporting clinicopathological characteristics, molecular marker expression, management non-anaplastic TC any proportion in adult patients. Of 2007 records retrieved, 82were included our (PROSPERO-ID545847). Conclusions: Our case, together review, imply that combination molecular-targetedtreatments may be safe effective patients RAI-resistantBRAF-mutated advanced when surgery failed control progression.
Language: Английский
Citations
2Effective analysis of thyroid toxicity and mechanisms of acetyltributyl citrate using network toxicology, molecular docking and machine learning strategies
Toxicology, Journal Year: 2024, Volume and Issue: 511, P. 154029 - 154029
Published: Dec. 8, 2024
Language: Английский
Citations
2Uncommon molecular alterations in follicular -derived thyroid carcinoma: a single institution study.
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 258, P. 155355 - 155355
Published: May 17, 2024
Language: Английский
Citations
0Aggressive Types of Malignant Thyroid Neoplasms
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6119 - 6119
Published: Oct. 14, 2024
Differentiated thyroid cancer (DTC) includes many subtypes, which demonstrate favorable to aggressive behavior. During the past decades, efforts have been made describe cancers. Within DTC, variants constitute rare entities with unique histopathological features and compromised survival, as local distant metastatic disease is frequent. In recent years, distinct category of poorly differentiated was introduced in 2004 type high-grade carcinoma recently added 2022 WHO classification neoplasms. Finally, anaplastic exhibits a rapid, resistant therapy, progression confers shortest survival. this review, we will present characteristics these types also discuss treatment, management, follow-up difficult cases. Emphasis given bibliography last decade.
Language: Английский
Citations
0Thyroid Pathology
Published: Jan. 1, 2024
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