Inflammopharmacology, Journal Year: 2022, Volume and Issue: 30(5), P. 1517 - 1531
Published: Aug. 26, 2022
Language: Английский
Acta Pharmacologica Sinica, Journal Year: 2022, Volume and Issue: 44(4), P. 695 - 709
Published: Oct. 17, 2022
Language: Английский
Citations
283
Medicina, Journal Year: 2022, Volume and Issue: 58(2), P. 144 - 144
Published: Jan. 18, 2022
A cytokine storm is a hyperinflammatory state secondary to the excessive production of cytokines by deregulated immune system. It manifests clinically as an influenza-like syndrome, which can be complicated multi-organ failure and coagulopathy, leading, in most severe cases, even death. The term was first used 1993 describe graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. then reused define adverse syndromes administration immunostimulating agents, such anti-CD28 antibodies or bioengineered cells, i.e., CAR T-cell therapy. Currently, concept has been better elucidated extended pathogenesis many other conditions, sepsis, autoinflammatory disease, primary hemophagocytic lymphohistiocytosis, multicentric Castleman disease. Moreover, recently emerged key aspect novel Coronavirus 2019, affected patients show high levels several pro-inflammatory cytokines, IL-1, IL-2, IL-6, TNF-α, IFN-γ, IP-10, GM-CSF, MCP-1, IL-10, some also correlate with severity. Therefore, since onset pandemic, numerous agents have tested effort mitigate COVID-19 patients, are effective reducing mortality, especially critically ill now becoming standards care, glucocorticoids inhibitors. However, challenge still far from being met, therapeutic strategies hope that we eventually overcome
Language: Английский
Citations
251
Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 408 - 408
Published: Feb. 10, 2023
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-stranded RNA (ssRNA) severe acute respiratory syndrome 2 (SARS-CoV-2). However, other human coronaviruses (hCoVs) exist. Historical pandemics include smallpox and influenza, with efficacious therapeutics utilized to reduce overall disease burden through effectively targeting competent host immune system response. is composed of primary/secondary lymphoid structures initially eight types cell types, many subtypes, traversing membranes utilizing signaling cascades that contribute towards clearance pathogenic proteins. Other proteins discussed cluster differentiation (CD) markers, major histocompatibility complexes (MHC), pleiotropic interleukins (IL), chemokines (CXC). historical concepts immunity are the innate adaptive systems. represented T cells, B antibodies. macrophages, neutrophils, dendritic complement system. viruses can affect regulate cycle progression for example, in cancers papillomavirus (HPV: cervical carcinoma), Epstein-Barr virus (EBV: lymphoma), Hepatitis C (HB/HC: hepatocellular carcinoma) Leukemia Virus-1 (T leukemia). Bacterial infections also increase risk developing cancer (e.g.,
Language: Английский
Citations
37
Diagnostics, Journal Year: 2021, Volume and Issue: 11(9), P. 1647 - 1647
Published: Sept. 8, 2021
Coronavirus disease 2019 (COVID-19) can potentially affect all organs owing to the ubiquitous diffusion of angiotensin-converting enzyme II (ACE2) receptor-binding protein. Indeed, SARS-CoV-2 virus is capable causing heart disease. This systematic review offer a new perspective on potential consequences COVID-19 through an analysis current literature cardiac involvement. review, conducted from March 2020 July 2021, searched for postmortem findings in patients who were positive by combining and meshing terms “COVID-19”, “postmortem”, “autopsy”, “heart” titles, abstracts, keywords. The PubMed database was following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. Sixteen papers met inclusion criteria (case reports series, original research, only English-written). A total 209 found (mean age (interquartile range (IQR)), 60.17 years (IQR, 54.75–70.75 years); 122 men (58.37%, ratio women 1:0.7%)). Each patient tested SARS-CoV-2. Death mainly result respiratory failure. second most common cause death acute Few specifically died myocarditis. Variables such as pathological findings, immunohistochemical data, previous clinical assessments analyzed. Main dilatation, necrosis, lymphocytic infiltration myocardium, small coronary vessel microthrombosis. Immunohistochemical analyses revealed inflammatory state dominated constant presence CD3+ CD8+ cytotoxic lymphocytes CD68+ macrophages. leads systemic response prothrombotic state. results our suggest that able irreversible changes several organs, including heart; this reflected increased risk survive COVID-19. Postmortem (including autopsy, histologic, examination) indispensable tool better understand caused emerging diseases Our may provide more information involvement patients.
Language: Английский
Citations
51
Frontiers in Toxicology, Journal Year: 2022, Volume and Issue: 4
Published: July 6, 2022
Reactive oxygen species (ROS) and reactive nitrogen (RNS) are formed as a result of natural cellular processes, intracellular signaling, or adverse responses associated with diseases exposure to oxidizing chemical non-chemical stressors. The action ROS RNS, collectively referred (RONS), has recently become highly relevant in number outcome pathways (AOPs) that capture, organize, evaluate portray causal relationships pertinent adversity disease progression. RONS can potentially act key event (KE) the cascade leading an (AO) within such AOPs, but also known modulate events along AOP continuum without being itself. A substantial discussion therefore been undertaken series workshops named “Mystery ROS” elucidate role effects stressors nanoparticles, chemical, ionizing non-ionizing radiation. This review introduces background for production, reflects on direct indirect RONS, addresses diversity terminology used different fields research, provides guidance developing harmonized approach defining common developer community.
Language: Английский
Citations
37
Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 235, P. 108121 - 108121
Published: Feb. 2, 2022
Language: Английский
Citations
31
Актуальные проблемы медицины, Journal Year: 2023, Volume and Issue: 46(3), P. 231 - 244
Published: Sept. 30, 2023
Новая коронавирусная инфекция внесла весомые коррективы в состояние пациентов, уже страдающих сердечно-сосудистыми заболеваниями. Похожие механизмы развития фиброза у пациентов с тяжелой формой COVID-19 и сердечной недостаточностью заставили обратить внимания на биомаркеры воспаления. Тяжелый цитокиновый шторм, характерный для COVID-19, имеет решающее значение понимания исхода заболевания. При тяжелом течении отмечены высокие уровни интерлейкина-2, интерлейкина-6, интерлейкина-10, моноцитарного хемотаксического белка-1 (MCP-1) фактора некроза опухоли-α (TNF-α), отличие от легкой умеренной Повышение уровня MCP-1 при позволяет предположить, что его секреция может играть одну из ключевых ролей реактивном воспалительном процессе, связанном COVID-19. Установлено, ИЛ-10 являются предикторами тяжести заболевания риска смерти таких пациентов. Матриксные металлопротеиназы (ММП) также оказываются вовлечены развитие патологии легких могут выступать качестве раннего индикатора дыхательной недостаточности В данном обзоре рассмотрены воспаления, такие как ММП, тканевой ингибитор матриксной металлопротеиназы-1, интерлейкины, MCP-1, предмет их возможности служить объективными маркерами ранней диагностики прогноза сердечно-сосудистых осложнений перенесших
Language: Русский
Citations
20
Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 308 - 308
Published: Feb. 18, 2024
Cytokines are signaling molecules that play a role in myriad processes, including those occurring during diseases and homeostasis. Their homeostatic function begins embryogenesis persists throughout life, appropriate for the cell organism death. During viral infections, antiviral cytokines such as interferons inflammatory upregulated. Despite well-known benefits of these cytokines, their levels often correlate with disease severity, linking them to unfavorable outcomes. In this review, we discuss both beneficial pathological functions potential challenges separating two roles. Further, targeting propose new method quantifying cytokine effect limit consequences while preserving effects.
Language: Английский
Citations
7
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 10, 2024
Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers illness severity these conditions.
Language: Английский
Citations
7
Journal of Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: 14(2), P. 363 - 378
Published: Feb. 20, 2024
Abstract Background Cytokine storm is known to impact the prognosis of coronavirus disease 2019 (COVID-19), since pro-inflammatory cytokine variants are associated with storm. It tempting speculate that cytokines may COVID-19 outcomes by modulating Here, we verified this hypothesis via a comprehensive analysis. Methods PubMed, Cochrane Library, Central, CINAHL, and ClinicalTrials.gov were searched until December 15, 2023. Case–control or cohort studies investigated impacts rs1800795 rs1800629 on susceptibility, severity, mortality, IL-6, TNF-α, CRP levels included after an anonymous review two independent reviewers consultations disagreement third reviewer. Results 47 (8305 individuals 17,846 non-COVID-19 individuals) analyzed. The A allele (adenine at −308 position promoter was encoded allele) higher tumor necrosis factor-α (TNF-α) C-reactive protein (CRP). In contrast, C (cytosine −174 linked interleukin-6 (IL-6) CRP. addition, increased severity mortality COVID-19. However, only susceptibility. Conclusions have significant systemic inflammatory profile clinical outcomes. serve as genetic marker for severe
Language: Английский
Citations
5