Effects of PEEP in intracranial pressure in patients with acute brain injury: An observational, prospective and multicenter study DOI Creative Commons
Jesús Abelardo Barea‐Mendoza, Zaira Molina Collado, M.Á. Ballesteros

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 15, 2023

Abstract Background The communication pathway between the brain and lung is called brain-lung crosstalk. effects of positive end-expiratory pressure (PEEP) in intracranial (ICP) are variable. We prospectively analyzed impact PEEP changes ICP dynamics patients with acute injury (ABI). Methods Observational, prospective multicenter study (PEEP-PIC study) including neurocritically ill who underwent invasive neuromonitorization from November, 2017 to June, 2018. Baseline ventilatory, hemodynamic neuromonitoring variables were collected immediately before during following 30 minutes. Ethics Committee approval for was initially obtained (Hospital Universitario 12 de Octubre, Madrid: CEI: 17/221). Written informed consent patients’ closest relatives. Results One-hundred nine included. Mean age 52.68 (15.34) years, male 71 (65.13%). Traumatic cause ABI 54 (49.54%) patients. Length mechanical ventilation 16.52 (9.23) days. In-hospital mortality 21.1%. Moderate increases (mean 6.24 9.10 cmH2O) resulted increase 10.4 11.39 mmHg, p < 0.001, without cerebral perfusion (CPP) (p = 0.548). decreases 8.96 6.53 decrease 10.5 9.62 mmHg 0.052), CPP 0.762). Significant correlations established delta (R 0.28, 0.001), driving 0.15, 0.038) compliance (R=-0.14, 0.052). increment higher lower baseline ICP. Conclusions not associated clinically relevant modifications values ABI. magnitude change after correlated PEEP, compliance. Patients had a percentage values.

Language: Английский

Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: The Role of the Complement and Innate Immune System DOI Creative Commons
J. Javier Provencio,

Sonya Inkelas,

Mervyn D.I. Vergouwen

et al.

Translational Stroke Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Specific inflammatory pathways are important in the development of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Understanding specific inflammation may be critical for finding new treatments. Evidence is accumulating that innate cells and proteins play a more role than adaptive system. In this work, we review evidence from clinical preclinical data regarding which immune system DCI with particular emphasis on bone-marrow-derived monocytes neutrophils brain parenchymal microglia. addition, will complement proteins, non-cellular part system, DCI.

Language: Английский

Citations

4
Effects of positive end-expiratory pressure on intracranial pressure, cerebral perfusion pressure, and brain oxygenation in acute brain injury: Friend or foe? A scoping review DOI Creative Commons

Greta Zunino,

Denise Battaglini, Daniel Agustín Godoy

et al.

Journal of Intensive Medicine, Journal Year: 2023, Volume and Issue: 4(2), P. 247 - 260

Published: Oct. 12, 2023

Patients with acute brain injury (ABI) are a peculiar population because ABI does not only affect the but also other organs such as lungs, theorized in brain-lung crosstalk models. patients often require mechanical ventilation (MV) to avoid complications of impaired respiratory function that can follow ABI; MV should be settled meticulousness owing its effects on intracranial compartment, especially regarding positive end-expiratory pressure (PEEP). This scoping review aimed (1) describe physiological basis and mechanisms related PEEP (2) examine how clinical research is conducted this topic; (3) identify methods for setting (4) investigate impact application outcome.

Language: Английский

Citations

10
Effects of PEEP on intracranial pressure in patients with acute brain injury: An observational, prospective and multicenter study DOI
Jesús Abelardo Barea‐Mendoza, Zaira Molina Collado, M.Á. Ballesteros

et al.

Medicina Intensiva, Journal Year: 2024, Volume and Issue: 48(10), P. 594 - 601

Published: Sept. 26, 2024

Language: Английский

Citations

3
Year in Review: Synopsis of Selected Articles in Neuroanesthesia and Neurocritical Care from 2024 DOI Creative Commons

I. Rahim,

Maximino Aldana,

Aishvarya Shree Nedunchezhian

et al.

Journal of Neuroanaesthesiology and Critical Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract This review is a synopsis of selected articles from neuroscience, neuroanesthesia, and neurocritical care 2024 (January–November 2024). The journals reviewed include anesthesia journals, critical medicine neurosurgical high-impact medical such as the Lancet, Journal American Medical Association, New England Medicine, Stroke. We identified that are randomized clinical trials, large retrospective prospective observational studies, systematic reviews, meta-analysis relevant to neuroanesthesia practice. excluded basic science research articles, case reports, series. summary important will serve update knowledge neuroanesthesiologists other perioperative physicians who provide cases.

Language: Английский

Citations

0
Advancements in understanding the mechanisms of lung–kidney crosstalk DOI Creative Commons
Renata de Souza Mendes, Pedro Leme Silva, Chiara Robba

et al.

Intensive Care Medicine Experimental, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 16, 2024

Language: Английский

Citations

2
Oral administration of lysozyme protects against injury of ileum via modulating gut microbiota dysbiosis after severe traumatic brain injury DOI Creative Commons

Weijian Yang,

Caihua Xi,

Haijun Yao

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 30, 2024

Objective The current study sought to clarify the role of lysozyme-regulated gut microbiota and explored potential therapeutic effects lysozyme on ileum injury induced by severe traumatic brain (sTBI) bacterial pneumonia in vivo vitro experiments. Methods Male 6–8-week-old specific pathogen-free (SPF) C57BL/6 mice were randomly divided into Normal group (N), Sham (S), sTBI (T), + or Lysozyme-treated (L), Lysozyme (NL) (SL). At day 7 after establishment model, anesthetized samples collected. lungs fresh contents ileocecum analyzed. Lungs distal used detect degree injury. number Paneth cells expression level assessed. translocation was determined. Intestinal organoids culture co-coculture system test whether remodels intestinal barrier through microbiota. Results After oral administration lysozyme, is rebalanced, composition lung restored, bacteria mitigated. reinstates cells, thereby reducing permeability, pathological score, apoptosis rate, inflammation levels. microbiota, including Oscillospira , Ruminococcus Alistipes Butyricicoccus Lactobacillus play a crucial regulating improving damage modulating lysozyme-treated mice. A co-culture comprising brain-derived proteins (BP), which demonstrated that BP effectively downregulated organoids. However, supplementation this failed restore its Conclusion present unveiled virtuous cycle whereby restores cell’s function, mitigates remodeling

Language: Английский

Citations

1
Effects of PEEP on intracranial pressure in patients with acute brain injury: An observational, prospective and multicenter study DOI
Jesús Abelardo Barea‐Mendoza, Zaira Molina Collado, M.Á. Ballesteros

et al.

Medicina Intensiva (English Edition), Journal Year: 2024, Volume and Issue: 48(10), P. 594 - 601

Published: May 29, 2024

Language: Английский

Citations

1
Multi‐Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk DOI Creative Commons

Joeng Ju Kim,

Mihyeon Bae, Dong‐Woo Cho

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(11)

Published: Sept. 19, 2024

Various systemic metabolic diseases arise from prolonged crosstalk across multiple organs, triggering serious impairments in various physiological systems. These are intricate pathologies characterized by complex mechanisms and an unclear etiology, making the treatment challenging. Efforts have been made to develop vitro models understand these devise new treatments. However, there limitations reconstructing causal relationships between interorgan crosstalk, including tissue-specific microenvironment. Alternatively, multi-organ microphysiological systems (MOMPS) present possibilities for capturing complexity of replicating human microphysiology simulating diverse crosstalk. Controlled interactions scalable representations biological MOMPS offer a more accurate portrayal organ interactions, enabling identification novel metabolism, immunity. This, turn, can yield valuable insights into disease drug development research enhance efficiency preclinical studies. In this review, examples technical capabilities pathological modeling discussed, leveraging state-of-the-art biofabrication technology MOMPS. It evaluates current opportunities challenges field.

Language: Английский

Citations

1
Ten good reasons to consider gastrointestinal function after acute brain injury DOI
Silvia De Rosa, Denise Battaglini, Juan Antonio Llompart‐Pou

et al.

Journal of Clinical Monitoring and Computing, Journal Year: 2023, Volume and Issue: 38(2), P. 355 - 362

Published: July 7, 2023

Language: Английский

Citations

3
Evaluating the protective role of trimetazidine versus nano-trimetazidine in amelioration of bilateral renal ischemia/reperfusion induced neuro-degeneration: Implications of ERK1/2, JNK and Galectin-3 /NF-κB/TNF-α/HMGB-1 signaling DOI
Fatma E. Hassan, Basma Emad Aboulhoda, Isra H. Ali

et al.

Tissue and Cell, Journal Year: 2023, Volume and Issue: 85, P. 102241 - 102241

Published: Oct. 16, 2023

Language: Английский

Citations

3