A comprehensive prognostic model for delayed cerebral ischemia in rupture intracranial aneurysms after surgical clipping DOI Creative Commons

Hui Zheng,

Hai Zhou,

Yutong Zhao

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract Background and Objectives : Delayed cerebral ischemia (DCI), one of the most common complications following aneurysmal subarachnoid hemorrhage (SAH), was strongly related to poor patient outcomes. Identifying predictive factors for its occurrence is crucial improving care Our research aimed explore risk delayed in aneurysm patients after surgical clipping developed a prediction model. Methods The datasets used this study are available from corresponding author upon reasonable request. Patients demographics, features, comorbidities, clinical manifestations, imaging blood pressure on admission，incidence DCI, interventions were recorded. SAH randomly assigned training or validation cohort based ratio 7:3, which implemented as internal validations final models. ability assessed by area under receiver operating characteristic (ROC) curve. Results A total 272 included our research. logistic model 7 independent predictors (Age, Smoking, Drinking, WFNS, Fisher, MAP Second postoperative day, Na) simple-to-use nomogram. set model's C-index 0.844 0.766, demonstrating moderate with regard risks DCI. Conclusion We seven predict incidence focused exploring status DCI patients. Elevated second day may indicate early microvascular spasm.

Language: Английский

Quantitative electroencephalography predicts delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a retrospective study DOI Creative Commons
Mengyuan Xu,

Pengzhao Zhang,

Yang Liu

et al.

Journal of Clinical Neuroscience, Journal Year: 2025, Volume and Issue: 136, P. 111284 - 111284

Published: April 26, 2025

Delayed cerebral ischemia (DCI) is a common complication that occurs in aneurysmal subarachnoid hemorrhage (aSAH). This can lead to clinical deterioration and poor prognosis. The aim of this study explore the risk factors for DCI aSAH patients neurological ICU, develop nomogram including quantitative electroencephalography (qEEG) parameters, evaluate its performance. We retrospectively analyzed processed Severe (SaSAH) from June 2022 May 2024 who underwent bedside qEEG monitoring indices, brain CT, data these patients. Logistic multivariate regression analysis was employed identify independent DCI. A prediction model form developed using R programming language subsequently evaluated performance quality. total 145 with SaSAH were included analysis, comprising 101 training set 44 validation set. 77 (53.10 %) Multivariate revealed GCS, modified Fisher grade, hypothermia, alpha/delta ratio (ADR) PAV grade exhibited excellent discriminative both (AUC = 0.84) 0.80). Quantitative EEG predict following SaSAH, resulting demonstrated substantial predictive value may help target therapies at highest secondary injury. It needs be further confirmed future by multi-center large sample studies.

Language: Английский

Citations

0
Biomarkers in Aneurysmatic and Spontaneous Subarachnoid Haemorrhage: A Clinical Prospective Multicentre Biomarker Panel Study of S100B, Claudin-5, Interleukin-10, TREM-1, TREM-2 and Neurofilament Light Chain As Well As Immunoglobulin G and M DOI Creative Commons
Thomas Kapapa,

Andreas Pfnür,

Rebecca Halbgebauer

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Following aneurysmatic subarachnoid haemorrhage (SAH), complex pathophysiological processes take place which result in ischaemia, dysfunction of the blood–brain barrier and clinical development vasospasms delayed cerebral ischaemia (DCI). The aim this study was to present a biomarker panel that can be used for temporal assignment process after haemorrhage, prediction vasospasm, DCI or outcome. In prospective multicentre approach, laboratory chemistry tests were determine value biomarkers S100B, Claudin-5, Interleukin (IL) -10, Triggering receptor expresses on myeloid cells (TREM)-1 TREM-2, neurofilament light chain (NfL) as well IgG IgM plasma Cerebro-spinal-fluid (CSF) SAH patients. predictive power mentioned with regard occurrence vasospasms, outcome (Glasgow Outcome Scale) defined by using sophisticated statistical methods level significance at p ≤ 0.05. Mean age 12 patients included 56 (SD:14) years 67% female 11 control subjects 74 (SD:3) 55% subjects. S100B showed higher concentrations compared first four days ( 0.0141). For IL-10, CSF continuous increase: day 2 = 0.0074), 4 0.0012), 5 < 0.0001). Regarding TREM1 TREM2 balance, increased until eight 0.0055). TREM-2 decreased below levels appeared unchanged further course. greatest difference concentration NfL between group seen 8 0.0104). differentiation without different curves CSF-plasma index increasing DCI. TREM Patients decreasing an increase when vasospasm detected. NfL, TREM-1 have potential relevant intermediate injury phase.

Language: Английский

Citations

0
Eighteen-Year Trends in Subarachnoid Hemorrhage Management and Outcomes: A Single-Center Experience DOI
Marie Renaudier, Vincent Degos, Gianluca Pisanu

et al.

Neurocritical Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Angiographic Response to Endovascular Treatment of Post-Hemorrhage Cerebral Vasospasm Is Not Associated with Clinical Outcome DOI
Faraz Behzadi, John T. Tsiang, Ronak Jani

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: 254, P. 108927 - 108927

Published: April 28, 2025

Language: Английский

Citations

0
The Progressive Frontier of Aneurysmal subarachnoid Hemorrhage: Diagnosis and treatment Advances DOI Creative Commons
Yi Luo, Maokun Li

Brain Hemorrhages, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

2
Year in Review: Synopsis of Selected Articles in Neuroanesthesia and Neurocritical Care from 2023 DOI Creative Commons

Sarah J. Hayes,

Kristof Nijs, Lashmi Venkatraghavan

et al.

Journal of Neuroanaesthesiology and Critical Care, Journal Year: 2024, Volume and Issue: 11(01), P. 003 - 009

Published: March 1, 2024

Abstract This review is a synopsis of selected articles from neuroscience, neuroanesthesia, and neurocritical care 2023 (January–November 2023). The journals reviewed include anesthesia journals, critical medicine neurosurgical as well high-impact medical such the Lancet, Journal American Medical Association, New England Medicine, Stroke. summary important will serve to update knowledge neuroanesthesiologists other perioperative physicians who provide patients.

Language: Английский

Citations

1
Sepsis and delayed cerebral ischemia are associated and have a cumulative effect on poor functional outcome in aneurysmal subarachnoid hemorrhage DOI Creative Commons
Franz-Simon Centner, Holger Wenz,

Mariella Eliana Oster

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 31, 2024

Objective Although sepsis and delayed cerebral ischemia (DCI) are severe complications in patients with aneurysmal subarachnoid hemorrhage (aSAH) share pathophysiological features, their interrelation additive effect on functional outcome is uncertain. We investigated the association between DCI cumulative aSAH using current sepsis-3 definition. Methods Patients admitted to our hospital 11/2014 11/2018 for were retrospectively analyzed. The main explanatory variable was sepsis, diagnosed criteria. Endpoints at discharge (modified Rankin Scale (mRS) 0–3 vs. 4–6). Propensity score matching (PSM) multivariable logistic regressions performed. Results Of 238 aSAH, 55 (23.1%) developed 74 (31.1%) DCI. After PSM, displayed significantly worse ( p &lt; 0.01) longer ICU stay = 0.046). Sepsis independently associated (OR 2.46, 95%CI: 1.28–4.72, 0.01). However, after exclusion of who before 1.59, 0.78–3.24, 0.21) or 0.85, 0.37–1.95, 0.70) this statistical did not remain. Good gradually decreased from 56.3% (76/135) neither nor DCI, 43.8% (21/48) those no but 34.5% (10/29) 7.7% (2/26) both Conclusion Our study demonstrates a strong suggests complex interplay resulting towards poor outcome, which warrants further studies.

Language: Английский

Citations

1
Association of Hemoglobin Decrement During Hospitalization with Prognosis of Aneurysmal Subarachnoid Hemorrhage and Mediation Effects of Cerebral Infarction and Pneumonia DOI Creative Commons

Xudong Che,

Baixue Wu,

Hongxia Zhang

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5349 - 5358

Published: Nov. 1, 2024

Hemoglobin decrement is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and associated with poor outcome. However, the mediating variables on causal pathway between hemoglobin outcome in aSAH are not clear.

Language: Английский

Citations

1
Ominous Causes of Headache DOI
Latha Ganti, Savithri Veluri, Thor S Stead

et al.

Current Pain and Headache Reports, Journal Year: 2023, Volume and Issue: 28(3), P. 73 - 81

Published: Dec. 13, 2023

Language: Английский

Citations

1
Association of sepsis and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage DOI Creative Commons
Franz-Simon Centner, Holger Wenz,

Mariella Eliana Oster

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 29, 2024

Abstract Background Although sepsis and delayed cerebral ischemia (DCI) are severe complications in patients with aneurysmal subarachnoid hemorrhage (aSAH) share pathophysiological features, their interrelation additive effect on functional outcome is uncertain. We investigated the association of DCI cumulative aSAH using current sepsis-3 definition. Methods Patients admitted to our hospital between 11/2014-11/2018 for were retrospectively analyzed. The main explanatory variable was sepsis, diagnosed criteria. Endpoints at discharge (modified Rankin Scale (mRS) 0-3 vs. 4-6). Propensity score matching (PSM) multivariable logistic regressions performed. Results Of 238 aSAH, 55 (23%) developed 74 (31%) DCI. After PSM, displayed significantly worse (p<0.01) longer ICU stay (p=0.046). Sepsis independently associated (OR=2.46, 95%CI: 1.28-4.72, p<0.01). However, after exclusion who before (OR=1.59, 0.78-3.24, p=0.21) or (OR=0.85, 0.37-1.95, p=0.70) this statistical did not remain. Good gradually decreased from 56% (76/135) neither nor DCI, 43% (21/48) those no but 34% (10/29) 8% (2/26) both Conclusions Our study demonstrates a strong suggests complex interplay resulting towards poor outcome, which warrants further studies.

Language: Английский

Citations

0