Frontiers in Cellular Neuroscience,
Journal Year:
2020,
Volume and Issue:
14
Published: Nov. 26, 2020
Background:
Exosomes,
especially
stem
cell-derived
exosomes,
have
been
widely
studied
in
pre-clinical
research
of
ischemic
stroke.
However,
their
pooled
effects
remain
inconclusive.
Methods:
Relevant
literature
concerning
the
exosomes
on
neurological
performance
a
rodent
model
stroke
was
identified
via
searching
electronic
databases,
including
PubMed,
Embase,
and
Web
Science.
The
primary
outcomes
included
function
scores
(NFS)
infarct
volume
(IV),
secondary
were
several
pro-inflammatory
factors
terminal
deoxynucleotidyl
transferase
deoxyuridine
triphosphate
nick
end
labeling-positive
cells.
Subgroup
analyses
regarding
potentially
influencing
NFS
IV
also
conducted.
Results:
We
21
experiments
from
18
studies
meta-analysis.
Pooled
showed
positive
significant
(standardized
mean
difference
−2.79;
95%
confidence
interval
−3.81
to
−1.76)
−3.16;
−4.18
−2.15).
Our
data
revealed
that
models
might
be
related
routes
administration
sources.
In
addition,
there
attenuation
factors,
interleukin-6,
tumor
necrosis
factor-α
interleukin-1β,
cells
when
undergoing
treatment.
Conclusion:
Cell-derived
treatment
demonstrated
statistically
improvements
structural
recovery
animal
results
provide
relatively
robust
evidence
supporting
as
promising
therapy
promote
individuals.
Frontiers in Neurology,
Journal Year:
2021,
Volume and Issue:
12
Published: Oct. 28, 2021
Background:
Stroke
is
the
leading
cause
of
death
and
disability.
Exercise
produces
neuroprotection
by
improving
neuroplasticity.
can
induce
exosome
production.
According
to
several
studies,
exosomes
are
involved
in
repairing
brain
function,
but
relationship
mechanism
exercise,
exosomes,
have
not
been
elucidated.
This
study
intends
explore
potential
observing
changes
level,
infarct
volume,
neurological
function
behavioral
scores,
synapses,
corticospinal
tract
(CST).
Methods:
Rats
were
randomly
divided
into
four
groups:
a
sham
operation
(SHAM)
group,
middle
cerebral
artery
occlusion
(MCAO)
with
sedentary
intervention
(SED-MCAO)
MCAO
exercise
(EX-MCAO)
injection
(EX-MCAO-EXO)
group.
The
was
started
1
day
after
lasted
for
4
weeks.
All
rats
assessed
using
modified
severity
score
(mNSS).
levels
serum
brain,
gait
analysis,
magnetic
resonance
scan
performed
weeks
intervention.
After
intervention,
number
synaptophysin
(Syn),
postsynaptic
density
protein
95(PSD-95)
expression
detected.
Results:
(1)
EX-MCAO
EX-MCAO-EXO
groups
showed
higher
(pEX-MCAO
=
0.000,
pEX-MCAO-EXO
0.000)
0.001,
than
SED-MCAO
which
group
had
highest
(p
0.03)
levels.
(2)
synapses
0.032)
significantly
that
exhibited
greater
(3)
synaptic
plasticity-associated
proteins
expressed
(pSyn
0.010,
pPSD-95
0.044)
0.046)
expression.
(4)
Compared
improved
volume
ratio
0.000),
rFA
value
rADC
0.000).
0.001).
(5)
0.001)
lower
mNSS
scores
gait.
(6)
negatively
correlated
score,
ratio,
positively
value,
Syn,
PSD-95
positive
correlation.
Conclusions:
increases
level
rats,
recruited
growth
CST
integrity,
reduced
Cell Communication and Signaling,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: July 22, 2022
Abstract
Based
on
clinical
observations,
stroke
is
touted
as
one
of
the
specific
pathological
conditions,
affecting
an
individual’s
life
worldwide.
So
far,
no
effective
treatment
has
been
introduced
to
deal
with
post-complications.
Production
and
release
several
neurotrophic
factors
by
different
cells
exert
positive
effects
ischemic
areas
following
stroke.
As
a
correlate,
basic
studies
have
focused
development
discovery
de
novo
modalities
introduce
these
timely
in
appropriate
doses
into
affected
areas.
Exosomes
(Exo)
are
non-sized
vesicles
released
from
many
during
physiological
conditions
participate
intercellular
communication.
These
particles
transfer
arrays
signaling
molecules,
like
acceptor
induce
cascades
favor
cell
bioactivity.
This
review
aimed
highlight
emerging
role
exosomes
therapeutic
approach
regeneration
Frontiers in Cellular Neuroscience,
Journal Year:
2020,
Volume and Issue:
14
Published: Nov. 26, 2020
Background:
Exosomes,
especially
stem
cell-derived
exosomes,
have
been
widely
studied
in
pre-clinical
research
of
ischemic
stroke.
However,
their
pooled
effects
remain
inconclusive.
Methods:
Relevant
literature
concerning
the
exosomes
on
neurological
performance
a
rodent
model
stroke
was
identified
via
searching
electronic
databases,
including
PubMed,
Embase,
and
Web
Science.
The
primary
outcomes
included
function
scores
(NFS)
infarct
volume
(IV),
secondary
were
several
pro-inflammatory
factors
terminal
deoxynucleotidyl
transferase
deoxyuridine
triphosphate
nick
end
labeling-positive
cells.
Subgroup
analyses
regarding
potentially
influencing
NFS
IV
also
conducted.
Results:
We
21
experiments
from
18
studies
meta-analysis.
Pooled
showed
positive
significant
(standardized
mean
difference
−2.79;
95%
confidence
interval
−3.81
to
−1.76)
−3.16;
−4.18
−2.15).
Our
data
revealed
that
models
might
be
related
routes
administration
sources.
In
addition,
there
attenuation
factors,
interleukin-6,
tumor
necrosis
factor-α
interleukin-1β,
cells
when
undergoing
treatment.
Conclusion:
Cell-derived
treatment
demonstrated
statistically
improvements
structural
recovery
animal
results
provide
relatively
robust
evidence
supporting
as
promising
therapy
promote
individuals.
