Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Jan. 8, 2025

PANoptosis is a novelly defined mode of programmed cell death that involves the activation multiple cellular pathways, including pyroptosis, apoptosis, and necroptosis, triggering robust inflammatory reactions. Autophagy crucial process maintains homeostasis protects cells from various stresses. autophagy, both vital players in intricate pathological progression ischemic stroke (IS), brain ailment governed by cascades, have garnered attention recent years for their potential interplay. While mounting evidence hints at crosstalk between these two processes IS, underlying mechanisms remain elusive. Therefore, this review delves into dissects underpin intersection autophagy devastating condition. In conclusion, IS presents promising target development novel therapies. Understanding interplay pathways offers much-needed insight opens possibility new therapeutic strategies.

Language: Английский

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Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4279 - 4295

Published: May 1, 2024

Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are type of cell that only found inside the nervous system. These can differentiate into various kinds cells, potentially regenerating or restoring neural networks within areas brain have been destroyed. This review begins by providing introduction existing approaches for ischemic followed examination promise limits associated with utilization NSCs treatment stroke. Subsequently, comprehensive overview was conducted synthesize literature on underlying processes cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy context mechanisms encompass neuroprotection, inflammatory response suppression, endogenous nerve vascular regeneration facilitation. Nevertheless, translation NSC-sEVs is hindered challenges such as inadequate targeting efficacy insufficient content loading. In light these limitations, we compiled advancements utilizing modified treating stroke based methods vesicle modification. conclusion, examining NSC-sEVs-based anticipated be both fundamental applied investigations about

Language: Английский

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Network Pharmacology Analysis and Experimental Validation of Tectoridin in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Inflammation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1402 - 1402

Published: Feb. 7, 2025

The flowers of Pueraria lobate (Puerariae Flos) have served as a traditional Chinese medicinal and food herbage plant for many years. Tectoridin is one the most active metabolites extracted from has variety beneficial activities, including antioxidative, hypoglycemic, anti-inflammatory activities. Nevertheless, functions potential mechanisms underlying tectoridin in cerebral ischemia/reperfusion injury not been well interpreted; thus, network analysis strategy was performed to systematically evaluate its pharmacological mechanisms, which were further validated rats with ischemia. Network predicted that could attenuate brain damage after stroke by modulating signaling pathways associated redox, inflammation, autophagy. experimental results demonstrated an improvement neurological function treated tectoridin, along significant reduction infarction volume. neuroprotective benefits stem, part, antioxidant capabilities, include upregulation Nrf2/HO-1 protein expression, TLR4/MYD88/NF-κB inflammatory pathway, inhibition PI3K/Akt/mTOR contributing anti-apoptotic effects. This investigation offers thorough examination targets linked therapeutic effects on ischemic stroke, highlighting anti-inflammatory, mechanisms. These findings serve valuable reference development exploration effective anti-ischemic medications.

Language: Английский

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Fighting ferroptosis: Protective effects of dexmedetomidine on vital organ injuries

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122949 - 122949

Published: Aug. 8, 2024

Language: Английский

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