The role of N6-methyladenosine modification in tumor angiogenesis DOI Creative Commons
Qin Li,

Xinya Zeng,

Xinze Qiu

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 3, 2024

Tumor angiogenesis is a characteristics of malignant cancer progression that facilitates cell growth, diffusion and metastasis, has an indispensable role in development. N6-methyladenosine (m6A) among the most prevalent internal modifications eukaryotic RNAs, considerable influence on RNA metabolism, including its transcription, splicing, localization, translation, recognition, degradation. The m6A modification generated by methyltransferases ("writers"), removed demethylases ("erasers"), recognized m6A-binding proteins ("readers"). There accumulating evidence abnormal involved pathogenesis multiple diseases, cancers, promotes occurrence, development, through impact oncoprotein expression. Furthermore, increasing studies have demonstrated can cancers pathways to regulate processes. In this review, we elaborate tumor angiogenesis-related molecules detail, providing insights into interactions between angiogenesis. Moreover, describe how targeting combination with anti-angiogenesis drugs expected be promising anti-tumor treatment strategy, potential value for addressing challenge drug resistance.

Language: Английский

Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis DOI
Kuang‐Ling Ou, Chih-Kuan Chen, Junxiang Huang

et al.

Cells and Development, Journal Year: 2024, Volume and Issue: 179, P. 203922 - 203922

Published: April 28, 2024

Language: Английский

Citations

2
Vascular Endothelial Growth Factor (VEGF) Family and the Immune System: Activators or Inhibitors? DOI Creative Commons
Cristina Maria Failla, Maria Luigia Carbone, Carmela Ramondino

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 6 - 6

Published: Dec. 24, 2024

The vascular endothelial growth factor (VEGF) family includes key mediators of vasculogenesis and angiogenesis. VEGFs are secreted by various cells epithelial mesenchymal origin some immune in response to physiological pathological stimuli. In addition, express VEGF receptors and/or co-receptors can respond an autocrine or paracrine manner. This immunological role has opened the possibility using inhibitors already developed inhibit tumor angiogenesis also combination approaches with different immunotherapies enhance action effector T lymphocytes against cells. review pursues examine current understanding interplay between system, while identifying areas that require further evaluation.

Language: Английский

Citations

2
The role of N6-methyladenosine modification in tumor angiogenesis DOI Creative Commons
Qin Li,

Xinya Zeng,

Xinze Qiu

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 3, 2024

Tumor angiogenesis is a characteristics of malignant cancer progression that facilitates cell growth, diffusion and metastasis, has an indispensable role in development. N6-methyladenosine (m6A) among the most prevalent internal modifications eukaryotic RNAs, considerable influence on RNA metabolism, including its transcription, splicing, localization, translation, recognition, degradation. The m6A modification generated by methyltransferases ("writers"), removed demethylases ("erasers"), recognized m6A-binding proteins ("readers"). There accumulating evidence abnormal involved pathogenesis multiple diseases, cancers, promotes occurrence, development, through impact oncoprotein expression. Furthermore, increasing studies have demonstrated can cancers pathways to regulate processes. In this review, we elaborate tumor angiogenesis-related molecules detail, providing insights into interactions between angiogenesis. Moreover, describe how targeting combination with anti-angiogenesis drugs expected be promising anti-tumor treatment strategy, potential value for addressing challenge drug resistance.

Language: Английский

Citations

0