Post-transcriptional control drives Aurora kinase A expression in human cancers DOI Creative Commons
Roberta Cacioppo,

Deniz Rad,

Giulia Pagani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

ABSTRACT Aurora kinase A (AURKA) is a major regulator of the cell cycle. prominent association exists between high expression AURKA and cancer, impairment levels can trigger its oncogenic activity. In order to explore contribution post-transcriptional regulation in different cancers, we carried out meta-analysis -omics data 18 cancer types from The Cancer Genome Atlas (TCGA). Our study confirmed general trend for increased mRNA compared normal tissues revealed that highly dependent on control several cancers. Correlation clustering analyses protein expression, AURKA-targeting hsa-let-7a miRNA, unveiled likely involved varying extents controlling We then measured differences short/long ratio (SLR) two alternative cleavage polyadenylation (APA) isoforms across cancers respective healthy counterparts. suggest interplay APA targeting may influence some also independently contribute altered levels. Therefore, argue are often discordant as result dynamic regulation.

Language: Английский

Research progress on the relationship between AURKA and tumorigenesis: the neglected nuclear function of AURKA DOI Creative Commons
Menghua Chen, Huijun Zhu, Jian Li

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: May 13, 2024

AURKA is a threonine or serine kinase that needs to be activated by TPX2, Bora and other factors. located on chromosome 20 amplified overexpressed in many human cancers, such as breast cancer. regulates some basic cellular processes, this regulation realized

Language: Английский

Citations

4
Copper(II) binuclear complexes with 3-Aminopyridine-2-carboxaldehyde N(4)-methylthiosemicarbazone: Synthesis, Crystal Structure, Biological Evaluation DOI
Peifang Wang, Chun Wang, Yuqing Wang

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141399 - 141399

Published: Jan. 1, 2025

Language: Английский

Citations

0
Computational identification and experimental characterization of an aurora kinase inhibitor DOI
Muhammad Muddassar, Muhammad Furqan, Numan Yousaf

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118160 - 118160

Published: March 1, 2025

Language: Английский

Citations

0
AURKA promotes renal cell carcinoma progression via regulation of CCNB1 transcription DOI Creative Commons
Jiling Wen, Xuechun Wang, Guosheng Yang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e27959 - e27959

Published: April 1, 2024

AURKA is a member of the serine/threonine kinase family and its activity crucial for progression mitosis. Recent studies have highlighted therapeutic significance inhibition in multiple cancer types. However, specific mechanisms by which contributes to renal cell carcinoma (RCC) not been fully elucidated. In this study, expression level was identified human RCC tissues immunohistochemical (IHC) staining. The function on malignant phenotypes evaluated

Language: Английский

Citations

1
Post-transcriptional control drives Aurora kinase A expression in human cancers DOI Creative Commons
Roberta Cacioppo,

Deniz Rad,

Giulia Pagani

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0310625 - e0310625

Published: Nov. 11, 2024

Aurora kinase A (AURKA) is a major regulator of the cell cycle. prominent association exists between high expression AURKA and cancer, impairment levels can trigger its oncogenic activity. In order to explore contribution post-transcriptional regulation in different cancers, we carried out meta-analysis -omics data 18 cancer types from The Cancer Genome Atlas (TCGA). Our study confirmed general trend for increased mRNA compared normal tissues revealed that highly dependent on control several cancers. Correlation clustering analyses protein expression, AURKA-targeting hsa-let-7a miRNA, unveiled likely involved varying extents controlling We then measured differences short/long ratio (SLR) two alternative cleavage polyadenylation (APA) isoforms across cancers respective healthy counterparts. suggest interplay APA targeting may influence some also independently contribute altered levels. Therefore, argue are often discordant as result dynamic regulation.

Language: Английский

Citations

0
Post-transcriptional control drives Aurora kinase A expression in human cancers DOI Creative Commons
Roberta Cacioppo,

Deniz Rad,

Giulia Pagani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

ABSTRACT Aurora kinase A (AURKA) is a major regulator of the cell cycle. prominent association exists between high expression AURKA and cancer, impairment levels can trigger its oncogenic activity. In order to explore contribution post-transcriptional regulation in different cancers, we carried out meta-analysis -omics data 18 cancer types from The Cancer Genome Atlas (TCGA). Our study confirmed general trend for increased mRNA compared normal tissues revealed that highly dependent on control several cancers. Correlation clustering analyses protein expression, AURKA-targeting hsa-let-7a miRNA, unveiled likely involved varying extents controlling We then measured differences short/long ratio (SLR) two alternative cleavage polyadenylation (APA) isoforms across cancers respective healthy counterparts. suggest interplay APA targeting may influence some also independently contribute altered levels. Therefore, argue are often discordant as result dynamic regulation.

Language: Английский

Citations

0