Monoclonal Antibody based Therapy against Cancer

Eastern Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 9(2)

Published: May 20, 2024

Cancer, as the most lethal illness, is characterized by uncontrolled growth of cells that can be somewhat treated in present day. Immunotherapy has been utilized to treat cancer it specificity against cells. Apart from chemotherapy, monoclonal antibody (mAb) therapy shown advanced effects treatment cancer. mAb one recent developments destroy tumor through different mechanisms such antibody-dependent cellular cytotoxicity, complement-dependent phagocytosis, or blocking signaling pathways. This review gives a brief outline types, efficiency action, challenges, and future perspectives therapy.

Language: Английский

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Monoclonal Antibody Therapies in Cancer Immunotherapy

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 419 - 472

Published: Aug. 28, 2024

Monoclonal antibodies (mAbs) can significantly improve patient outcomes in cancer treatment while reducing related side effects, offering a targeted therapy alternative to traditional regimens. This chapter describes the development, mechanisms, and applications of mAb therapies as critical components immunotherapy. The covers history progression use mAbs therapy, their multiple mechanisms—such immune checkpoint inhibitors, acumen for antigens antibody—drug conjugates—and newest developments this area. Moreover, reviews relevant case studies trial data compare impact these agents on various malignancies. concludes with summary current challenges—developed resistance, one hand—and toxic e.g., cytokine release syndrome neurotoxicity, other—and prospective avenues field.

Language: Английский

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Anticancer Activity of Green Synthesized Manganese Doped Cerium Oxide Nanoparticles Prepared by Using Acacia Concinna Fruit Extract

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(41)

Published: Oct. 29, 2024

Abstract Pure CeO 2 and Ce 1‐x Mn x O , where = 0, 2, 4 6% w/w, were synthesized by sol‐gel method using Acacia Concinna fruit extract as a surfactant stabilizing agent. The particles subjected to various characterization techniques, including XRD, HRTEM, FESEM, FTIR, Raman UV‐Visible spectroscopy. XRD pattern of the samples demonstrated single phase with cubic fluorite type structure crystallite size 6–7 nm. morphology nanoparticles (NPs) was analyzed FESEM HRTEM which illustrated an aggregate irregular spherical average particle is around 18 spectroscopy validated purity indicated about structural defects caused dopants. bandgap energy NPs calculated be 3.00 eV from Tauc plot spectroscopy, gradually decreased 2.43 increase in manganese doping. Cytotoxicity studies signified role Mn‐doped potential nanotherapeutic agent for cancer treatment. cell viability assay showed that 200 µg/mL exhibited remarkable cytotoxic effect inhibiting 50% cells both breast colon lines without affecting healthy lines.

Language: Английский

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Innovations in mRNA-based cancer immunotherapy: Challenges and future directions

World Journal of Biology Pharmacy and Health Sciences, Journal Year: 2024, Volume and Issue: 20(2), P. 702 - 724

Published: Nov. 30, 2024

Messenger RNA (mRNA) vaccines have quickly become a potent tool in cancer immunotherapy, with the potential to personalise treatment and get around many of drawbacks conventional therapies. With an emphasis on their processes, technological developments, clinical applications, this study examines scientific breakthroughs difficulties surrounding mRNA vaccines. We begin by investigating ways which work stimulate immune system, encode antigens specific tumours, elicit anti-tumor response. also look at variety are currently being deployed emphasize successes studies, especially when combined checkpoint inhibitors. The effectiveness safety these been significantly increased such as enhancements stability, design, delivery systems (such lipid nanoparticles polyplexes). Emerging technologies like circular self-amplifying present promising opportunities for enduring more But there still limitations vaccines, immunogenicity, degradation, effective vivo delivery. Concerns about possible adverse effects long-term applications covered review. Despite obstacles, novel approaches developed boost antigen expression, optimize systems, improve establishing crucial component tailored immunotherapy. These developments provide foundation upcoming advances vaccine technology represent major breakthrough fight against cancer.

Language: Английский

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Structural insight into CD20/CD3-bispecific antibodies by molecular modeling

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 185, P. 109497 - 109497

Published: Dec. 13, 2024

Language: Английский

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