Piperlongumine inhibits glioblastoma proliferation by inducing ferroptosis DOI

Jianting Qiu,

Fangzhou Guo,

Ji Shi

et al.

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Objectives This study aimed to investigate the effects of Piperlongumine on Glioblastoma multiforme. Methods The viability and proliferation glioma cells LN229 A172 were measured. Changes in mitochondrial structure observed. Cell proliferative capacity was assessed using immunofluorescence. levels glutathione, malondialdehyde, 4-hydroxynonenal, intracellular reactive oxygen species detected. ferroptosis-related proteins A plasmid transfection performed overexpress nuclear factor erythroid 2-related 2 gene; a subcutaneous tumor model established nude mice observe vivo inhibitory multiforme recovery effect Fer-1. expression detected immunohistochemistry. Key findings inhibited cells, as well their proliferation. ferroptosis inhibitors able restore cell Forced overexpression partially reversed Piperlongumine-induced ferroptosis; exhibited significant vivo, which could be restored by Conclusions inhibits inducing vitro model.

Language: Английский

New insights into zinc alleviating renal toxicity of arsenic-exposed carp (Cyprinus carpio) through YAP-TFR/ROS signaling pathway DOI

Hongmin Lu,

Yue Zhang, Xintong Zhang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 205, P. 106153 - 106153

Published: Sept. 25, 2024

Language: Английский

Citations

27
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation DOI
Yan Niu, Chunyu Liu, Lizhou Jia

et al.

Human Cell, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 8, 2025

Language: Английский

Citations

0
SMARCC1 promotes M2 macrophage polarization and reduces ferroptosis in lung cancer by activating FLOT1 transcription DOI
Ye Tao,

Huafeng Ji,

Wensheng Hu

et al.

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

Citations

0
Naringenin counteracts LPS-induced inflammation and immune deficits in chicken thymus by alleviating mtROS/ferroptosis levels DOI Creative Commons
Fei Yu, Xu Shi, Ké Li

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104179 - 104179

Published: Aug. 6, 2024

Naringenin is a flavonoid with significant anti-inflammatory and antioxidant properties. Mitochondrial dynamics, the mitochondrial respiratory chain, mtROS are closely related to each other regulate various biological processes. Ferroptosis inflammatory responses immune function in multiple tissues organs. However, whether naringenin can alleviate LPS-induced inflammation disorders chicken thymus via mtROS/ferroptosis has not been reported. Therefore, this study, we constructed MSB-1 cell models of LPS based on screening for concentrations that have positive effects further investigate anti-inflammatory, antiferroptosis, maintenance naringenin. The results showed 40 mg/kg alleviated tissue damage, elevated serum factors, decreased factors. mechanism by which attenuates release alleviating imbalance dynamics blockage chain. effect lipid peroxidation, disruption GSH/GSSG system, iron overload, GPx4 inactivation, thereby attenuating ferroptosis tissue, was inhibited addition activators. In conclusion, alleviates release.

Language: Английский

Citations

2
Design, synthesis and biological evaluation of artesunate-Se derivatives as anticancer agents by inducing GPX4-mediated ferroptosis DOI

Meilin Ren,

Simin Liang,

Sitong Lin

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 152, P. 107733 - 107733

Published: Aug. 16, 2024

Language: Английский

Citations

2
Role of UFMylation in tumorigenesis and cancer immunotherapy DOI Creative Commons
Lijuan Ding, Xin Jiang, Te Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 23, 2024

Protein post-translational modifications (PTMs) represent a crucial aspect of cellular regulation, occurring after protein synthesis from mRNA. These modifications, which include phosphorylation, ubiquitination, acetylation, methylation, glycosylation, Sumoylation, and palmitoylation, play pivotal roles in modulating function. PTMs influence localization, stability, interactions, thereby orchestrating variety processes response to internal external stimuli. Dysregulation is linked spectrum diseases, such as cancer, inflammatory neurodegenerative disorders. UFMylation, type PTMs, has recently gained prominence for its regulatory role numerous processes, including stress, key signaling pathways influencing functions. This review highlights the function UFMylation development progression tumors, underscoring potential therapeutic target. Moreover, we discuss tumorigenesis malignant progression, explore impact on cancer immunotherapy. The article aims provide comprehensive overview biological functions propose how targeting could enhance effectiveness immunotherapy strategies.

Language: Английский

Citations

1
Piperlongumine inhibits glioblastoma proliferation by inducing ferroptosis DOI

Jianting Qiu,

Fangzhou Guo,

Ji Shi

et al.

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Objectives This study aimed to investigate the effects of Piperlongumine on Glioblastoma multiforme. Methods The viability and proliferation glioma cells LN229 A172 were measured. Changes in mitochondrial structure observed. Cell proliferative capacity was assessed using immunofluorescence. levels glutathione, malondialdehyde, 4-hydroxynonenal, intracellular reactive oxygen species detected. ferroptosis-related proteins A plasmid transfection performed overexpress nuclear factor erythroid 2-related 2 gene; a subcutaneous tumor model established nude mice observe vivo inhibitory multiforme recovery effect Fer-1. expression detected immunohistochemistry. Key findings inhibited cells, as well their proliferation. ferroptosis inhibitors able restore cell Forced overexpression partially reversed Piperlongumine-induced ferroptosis; exhibited significant vivo, which could be restored by Conclusions inhibits inducing vitro model.

Language: Английский

Citations

0