The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 54

Published: April 5, 2025

Cancer is a leading cause of mortality and morbidity worldwide. Nanomaterials, unique optical, magnetic, electrical properties at the nanoscale (1-100 nm), have been engineered to improve drug capacity, bioavailability, specificity in cancer treatment. These advancements address toxicity lack selectivity conventional therapies, enabling precise targeting cells, tumor microenvironment, immune system. Among emerging approaches, bacterial treatment shows promise due its natural ability target diverse therapeutic mechanisms, which nanotechnology can further enhance. Bacteria-based delivery systems leverage bacteria's adaptability survival strategies within human body. Bacterial derivatives, such as ghosts (BGs), extracellular vesicles (BEVs), dietary toxins, are recognized effective biological nanomaterials capable carrying nanoparticles (NPs). attracted increasing attention for their potential targeted NP This study explores use various bacteria byproducts vehicles, highlighting treating different types cancer. By combining strengths therapy, these innovative approaches aim revolutionize with improved precision efficacy.

Language: Английский

Size dependent impact of platinum nanoparticles on doxorubicin activity

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107094 - 107094

Published: April 1, 2025

Cancer is a leading cause of death worldwide, with nearly 10 million fatalities yearly. Consequently, despite the search for new therapeutic approaches, use classical chemotherapy, remains one main treatment regimens. Therefore, we evaluate platinum nanoparticles (PtNPs) different sizes as potential modulators doxorubicin (DOX) activity. In presented research, utilized wide range methods, including Spectroscopic measurements, Isothermal Titration Calorimetry, Dynamic Light Scattering, and Atomic Force Microscopy, well biological assays such Ames mutagenicity test on Salmonella enterica serovar Typhimurium TA98 alamarBlue cytotoxicity assay Fluorescent Confocal Microscopy non-cancerous HaCaT cancerous MelJuSo cell lines, to investigate interactions between PtNPs DOX effect diverse-sized The obtained results indicate presence direct interactions, particularly highlighting differences related particles size. We confirmed that affects aggregation nanoparticles, while induce fluorescence quenching. terms aspects, reduced DOX, increased survival cells. Furthermore, 70 nm significantly effects cells by negatively affecting their morphology culture density. To conclude, our research provided valuable insights into particular emphasis nanoparticles' size influence impact providing base further future modification in approaches.

Language: Английский

Molecular mechanisms and clinical significance of perineural invasion in malignancies: the pivotal role of tumor-associated Schwann cells in cancer progression and metastasis

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 21, 2025

Language: Английский