Advances in T Cell-Based Cancer Immunotherapy: From Fundamental Mechanisms to Clinical Prospects DOI
Kaili Zhang,

Yi Zhang,

Xiang Pan

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

T cells and their cell receptors (TCRs) play crucial roles in the adaptive immune system's response against pathogens tumors. However, immunosenescence, characterized by declining function quantity with age, significantly impairs antitumor immunity. Recent years have witnessed remarkable progress cell-based cancer treatments, driven a deeper understanding of biology innovative screening technologies. This review comprehensively examines maturation mechanisms, cell-mediated responses, implications thymic involution on diversity prognosis. We discuss recent advances adoptive therapies, including tumor-infiltrating lymphocyte (TIL) therapy, engineered receptor (TCR-T) chimeric antigen (CAR-T) therapy. Notably, we highlight emerging DNA-encoded library technologies mammalian for high-throughput TCR-antigen interactions, which are revolutionizing discovery novel tumor antigens optimization TCR affinity. The also explores strategies to overcome challenges solid microenvironment approaches enhance efficacy As our deepens advances, immunotherapies show increasing promise delivering durable clinical benefits broader patient population.

Language: Английский

Molecular mechanisms and clinical significance of perineural invasion in malignancies: the pivotal role of tumor-associated Schwann cells in cancer progression and metastasis DOI

Noura A. A. Ebrahim,

Soliman M. A. Soliman,

Maha Othman

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 21, 2025

Language: Английский

Citations

0
In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation DOI Creative Commons

Veroniaina Hanitrarimalala,

Zdenka Prgomet,

My Hedhammar

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Colorectal cancer (CRC) is a leading global with high mortality, especially in metastatic cases, limited therapeutic options. The tumor microenvironment (TME), network comprising various immune cells, stromal cells and extracellular (ECM) components plays crucial role influencing progression therapy outcome. genetic heterogeneity of CRC the complex TME complicates development effective, personalized treatment strategies. prognosis has slowly improved during past decades, but (mCRC) common among patients still associated low survival. options for differ from those mCRC include surgery (mostly CRC), chemotherapy, growth factor receptor signaling pathway targeting, as well immunotherapy. Malignant are established TME, which varies depending on primary or site. Herein, we review interactions several ECM 3D models an emphasis how affects treatment. This comprehensive summary provides support that mimic within will be essential novel anticancer therapies.

Language: Английский

Citations

0
Advances in T Cell-Based Cancer Immunotherapy: From Fundamental Mechanisms to Clinical Prospects DOI
Kaili Zhang,

Yi Zhang,

Xiang Pan

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

T cells and their cell receptors (TCRs) play crucial roles in the adaptive immune system's response against pathogens tumors. However, immunosenescence, characterized by declining function quantity with age, significantly impairs antitumor immunity. Recent years have witnessed remarkable progress cell-based cancer treatments, driven a deeper understanding of biology innovative screening technologies. This review comprehensively examines maturation mechanisms, cell-mediated responses, implications thymic involution on diversity prognosis. We discuss recent advances adoptive therapies, including tumor-infiltrating lymphocyte (TIL) therapy, engineered receptor (TCR-T) chimeric antigen (CAR-T) therapy. Notably, we highlight emerging DNA-encoded library technologies mammalian for high-throughput TCR-antigen interactions, which are revolutionizing discovery novel tumor antigens optimization TCR affinity. The also explores strategies to overcome challenges solid microenvironment approaches enhance efficacy As our deepens advances, immunotherapies show increasing promise delivering durable clinical benefits broader patient population.

Language: Английский

Citations

0