Molecular mechanisms of radiation resistance in colorectal cancer: in silico identification of AURKA, BIRC5 and PLK1 proteins as potential biomarkers
International Journal of Radiation Biology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: April 28, 2025
The
development
of
radiation
resistance
by
tumor
cells
severely
affects
the
survival
colorectal
cancer
patients.
aim
this
work
is
to
study
molecular
mechanisms
involved
in
radiotherapy
treatment
and
identification
key
genes
as
possible
biomarkers.
Data
mining
was
performed
PubMed
with
keywords
'colorectal
neoplasms',
'radiotherapy',
'resistance',
generating
a
total
242
articles
which
series
inclusion
exclusion
criteria
were
applied
select
interest.
Then,
an
in-silico
analysis
selected
bioinformatic
tools:
GeneCodis,
Metascape,
KEGG,
REACTOME,
STRING,
STITCH,
CHEA3,
DGIdb,
CTD,
GEPIA.
Different
described.
These
are
related
evasion
apoptosis,
cell
cycle
dysregulation,
epithelial-mesenchymal
transition,
repair
DNA
breaks,
last
one
being
most
relevant
influential.
In-silico
carried
out
21
showed
implication
FoxO
signaling
EGFR
tyrosine
kinase
inhibitor
enriched
pathways.
In
addition,
identified
proteins
AURKA,
BIRC5,
PLK1,
showing
multiple
interacting
chemicals
drugs;
such
tamoxifen,
omacetaxine
mepesuccinate,
hydroxyzine
pamoate,
among
others.
transcription
factors
that
regulate
expression
these
well
validation
patient
samples
where
higher
observed
patients,
conserved
across
stages
I-IV,
suggests
their
potential
Language: Английский
Exploring the Antidiabetic Potential of Salvia officinalis Using Network Pharmacology, Molecular Docking and ADME/Drug-Likeness Predictions
Plants,
Journal Year:
2024,
Volume and Issue:
13(20), P. 2892 - 2892
Published: Oct. 16, 2024
A
combination
of
network
pharmacology,
molecular
docking
and
ADME/drug-likeness
predictions
was
employed
to
explore
the
potential
Language: Английский