Biologics, theranostics, and personalized medicine in drug delivery systems
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
201, P. 107086 - 107086
Published: Jan. 29, 2024
The
progress
in
human
disease
treatment
can
be
greatly
advanced
through
the
implementation
of
nanomedicine.
This
approach
involves
targeted
and
cell-specific
therapy,
controlled
drug
release,
personalized
dosage
forms,
wearable
delivery,
companion
diagnostics.
By
integrating
cutting-edge
technologies
with
delivery
systems,
greater
precision
achieved
at
tissue
cellular
levels
use
stimuli-responsive
nanoparticles,
development
electrochemical
sensor
systems.
targeting
–
by
virtue
nanotechnology
allows
for
therapy
to
directed
specifically
affected
tissues
while
reducing
side
effects
on
healthy
tissues.
As
such,
nanomedicine
has
potential
transform
conditions
such
as
cancer,
genetic
diseases,
chronic
illnesses
facilitating
precise
delivery.
Additionally,
forms
devices
offer
ability
tailor
unique
needs
each
patient,
thereby
increasing
therapeutic
effectiveness
compliance.
Companion
diagnostics
further
enable
efficient
monitoring
response,
enabling
customized
adjustments
plan.
question
whether
all
approaches
outlined
here
are
viable
alternatives
current
treatments
is
also
discussed.
In
general,
application
field
biomedicine
may
provide
a
strong
alternative
existing
several
reasons.
this
review,
we
aim
present
evidence
that,
although
early
stages,
fully
merging
technology
innovative
shows
promise
successful
across
various
areas,
including
cancer
or
diseases.
Language: Английский
Novel vaccine strategies to induce respiratory mucosal immunity: advances and implications
MedComm,
Journal Year:
2025,
Volume and Issue:
6(2)
Published: Jan. 16, 2025
Rapid
advances
in
vaccine
technology
are
becoming
increasingly
important
tackling
global
health
crises
caused
by
respiratory
virus
infections.
While
traditional
vaccines,
primarily
administered
intramuscular
injection,
have
proven
effective,
they
often
fail
to
provide
the
broad
upper
tract
mucosal
immunity,
which
is
urgently
needed
for
first-line
control
of
viral
Furthermore,
vaccines
may
not
adequately
address
immune
escape
emerging
variants.
In
contrast,
developed
using
body's
response
mechanism
can
simultaneously
establish
both
systemic
and
immunity.
This
dual
action
effectively
allows
system
function
as
first
line
defense,
preventing
infections
at
entry
points.
review
highlights
efficacy
including
innovative
delivery
methods
such
nasal
oral
formulations,
enhancing
local
barriers.
Notably,
offer
potential
advantages
protecting
against
variants
maintaining
long-term
multidimensional
memory
tract.
addition,
a
combination
largely
improves
their
coverage
effectiveness,
providing
valuable
insights
future
development
public
inoculation
strategies.
Language: Английский
What Is the Optimal Geometry of Dissolving Microneedle Arrays? A Literature Review
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 124 - 124
Published: Jan. 17, 2025
The
application
of
dissolving
microneedle
arrays
(DMNAs)
is
an
emerging
trend
in
drug
and
vaccine
delivery
as
alternative
for
hypodermic
needles
or
other
less
convenient
administration
methods.
major
benefits
include,
amongst
others,
that
no
trained
healthcare
personnel
required
the
recipient
experiences
hardly
any
pain
during
administration.
However,
a
successful
from
DMNA,
microneedles
should
be
inserted
intact
into
skin.
A
penetration
upper
skin
layers
may
challenging
because
elastic
nature
skin;
therefore,
minimum
insertion
force
to
overcome
total
resistance
In
addition,
need
stay
intact,
which
requires
certain
mechanical
strength,
able
resist
force.
addition
type
material
with
DMNAs
are
produced,
geometry
will
also
have
profound
effect,
not
only
on
strength
but
number
insertions
depth
this
review,
effects
shape,
aspect
ratio,
length,
width
base,
tip
diameter
angle,
spacing
aforementioned
effect
parameters
were
evaluated
answer
following
question:
‘What
optimal
arrays?’.
Language: Английский
The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles
Ziyao Chang,
No information about this author
Yuhuan Wu,
No information about this author
Ping Hu
No information about this author
et al.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 286 - 286
Published: Feb. 17, 2024
Transdermal
drug
delivery
systems
are
rapidly
gaining
prominence
and
have
found
widespread
application
in
the
treatment
of
numerous
diseases.
However,
they
encounter
challenge
a
low
transdermal
absorption
rate.
Microneedles
can
overcome
stratum
corneum
barrier
to
enhance
Among
various
types
microneedles,
nanoparticle-loaded
dissolving
microneedles
(DMNs)
present
unique
combination
advantages,
leveraging
strengths
DMNs
(high
payload,
good
mechanical
properties,
easy
fabrication)
nanocarriers
(satisfactory
solubilization
capacity
controlled
release
profile).
Consequently,
hold
considerable
clinical
potential
precision
medicine
era.
Despite
this
promise,
no
DMN
products
been
approved
thus
far.
The
lack
understanding
regarding
their
vivo
fate
represents
critical
bottleneck
impeding
translation
relevant
products.
This
review
aims
elucidate
current
research
status
elaborate
necessity
investigate
from
diverse
aspects.
Furthermore,
it
offers
insights
into
entry
points
for
DMNs,
aiming
foster
further
advancements
field.
Language: Английский
Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications
Zohre Eftekhari,
No information about this author
Horieh Zohrabi,
No information about this author
Akbar Oghalaie
No information about this author
et al.
Molecular Therapy — Nucleic Acids,
Journal Year:
2024,
Volume and Issue:
35(3), P. 102313 - 102313
Published: Aug. 19, 2024
The
use
of
mRNA
and
ribonucleoproteins
(RNPs)
as
therapeutic
agents
is
a
promising
strategy
for
treating
diseases
such
cancer
infectious
diseases.
This
review
provides
recent
advancements
challenges
in
mRNA-
RNP-based
therapies,
focusing
on
delivery
systems
lipid
nanoparticles
(LNPs),
which
ensure
efficient
to
target
cells.
Strategies
microfluidic
devices
are
employed
prepare
LNPs
loaded
with
RNPs,
demonstrating
effective
genome
editing
protein
expression
vitro
vivo.
These
applications
extend
treatment
disease
management,
results
therapy
using
encapsulating
Cas9
single-guide
RNA.
In
addition,
tissue-specific
targeting
strategies
offer
potential
improved
outcomes
reduced
off-target
effects.
Despite
progress,
optimizing
efficiency
remain.
Future
research
should
enhance
efficiency,
explore
targeting,
investigate
combination
advance
clinical
translation.
conclusion,
therapies
avenue
various
have
the
revolutionize
medicine,
providing
new
hope
patients
worldwide.
Language: Английский
Applications and prospects of biomaterials in diabetes management
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 7, 2025
Diabetes
is
a
widespread
metabolic
disorder
that
presents
considerable
challenges
in
its
management.
Recent
advancements
biomaterial
research
have
shed
light
on
innovative
approaches
for
the
treatment
of
diabetes.
This
review
examines
role
biomaterials
diabetes
diagnosis
and
treatment,
as
well
their
application
managing
diabetic
wounds.
By
evaluating
recent
developments
alongside
future
obstacles,
highlights
promising
potential
care,
underscoring
importance
enhancing
patient
outcomes
refining
methodologies.
Language: Английский
A review on microneedle patch as a delivery system for proteins/peptides and their applications in transdermal inflammation suppression
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
307, P. 141963 - 141963
Published: March 12, 2025
Language: Английский
3D Printed Hollow Microneedles for Dermal and Transdermal Drug Delivery: Design, Fabrication, Application, and Perspective
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 5, 2025
Hollow
microneedles
(HMNs)
offer
a
transformative
solution
for
topical
diagnosis
and
therapeutic
applications
due
to
the
unique
challenges
addressed
by
their
ability
adjust
dosing
integration
capabilities
in
context
of
microfluidic
microelectronic
devices.
To
fabricate
HMN
devices,
3D
printing
has
been
introduced
as
an
advanced
manufacturing
technology
fabricating
high-resolution
micro-
nanofeatures
overcoming
inferior
traditional
technologies
such
lithography,
etching,
laser
fabrication
producing
sophisticated
In
this
paper,
comprehensive
review
recent
advancements
utilization
developing
devices
is
provided.
The
current
are
summarized.
addition,
design,
fabrication,
testing
considerations
generating
Various
applications,
including
drug
delivery,
sensing,
recording,
along
with
integrated
necessary
these
highlighted.
Finally,
limitations
approaches
discussed,
future
fabricated
proposed.
summary,
Review
provides
insight
into
status
printed
roadmap
HMNs
design
criteria,
considerations,
postprocessing
approaches,
required
device
functionality
evaluation.
Language: Английский