Proteomic identification of potential biomarkers for heat tolerance in Caracu beef cattle using high and low thermotolerant groups DOI Creative Commons
Ana Cláudia de Freitas, Henrique G. Reolon, Natalya Gardezani Abduch

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 13, 2024

Heat stress has deleterious effects on physiological and performance traits in livestock. Within this context, using tropically adapted cattle breeds pure herds or terminal crossbreeding schemes to explore heterosis is attractive for increasing animal production warmer climate regions. This study aimed identify biological processes, pathways, potential biomarkers related thermotolerance Caracu, a beef breed, by proteomic analysis of blood plasma. To achieve goal, 61 bulls had their evaluated through heat tolerance index. A subset 14 extreme animals, including the seven most thermotolerant (HIGH group) least (LOW group), plasma samples used liquid chromatography coupled tandem mass spectrometry (LC-MS/MS). The differentially regulated proteins detected between HIGH LOW groups were perform functional enrichment protein-protein interaction network analysis. total 217 only group 51 group. In addition, 81 87 significantly higher lower abundancies group, respectively. Regarding with highest absolute log-fold change values, we highlighted those encoded DUSP5, IGFALS, ROCK2, RTN4, IRAG1, NNT genes based functions. several molecular functions, pathways cellular responses stress, immune system, complement hemostasis both groups, addition terms lipids calcium Protein-protein (PPI) revealed as important nodes many roles response hemostasis, inflammation, homeostasis. Additionally, high values essential PPI herein are thermotolerance, such ADRA1A, APOA1, APOB, APOC3, C4BPA, CAT, CFB, CFH, CLU, CXADR, DNAJB1, DNAJC13, FGA, FGB, FGG, HBA, HBB, HP, HSPD1, KNG1, NNT, OSGIN1, PROC, PROS1, RYR1, TGFB2, VLDLR, VTN, VWF. Identifying biomarkers, mechanisms that act contributes developing strategies improve welfare livestock under tropical climates.

Language: Английский

Decoding Local Adaptation in the Exploited Native Marine Mussel Mytilus chilensis: Genomic Evidence from a Reciprocal Transplant Experiment DOI Open Access
Marco Yévenes, Gonzalo Gajardo, Cristian Gallardo‐Escárate

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 931 - 931

Published: Jan. 23, 2025

Local adaptations are important in evolution as they drive population divergence and preserve standing genetic diversity essential for resilience under climate change human impacts. Protecting locally adapted populations is aquaculture species. However, high larval connectivity frequent translocations challenge this Chilean blue mussel (Mytilus chilensis) aquaculture, a world-class industry Chiloé Island. This study examined local two ecologically distinct natural beds, Cochamó (northernmost inner sea of Chiloé) Yaldad (southernmost tip), through 91-day reciprocal transplant experiment genomic evidence. mussels grew faster their native environment (0.015 g/day) than (0.004 g/day), though growth declined upon transplantation. Mussels transplanted within between beds displayed distinctive adaptive transcriptomic responses, with differentially expressed genes involved immune function, osmoregulation, metabolism, cellular balance. Additionally, 58 known outlier SNPs mapped over the species’ genome sequence were linked oxidative stress, oxygen management, revealing selection-targeted specific regions. highlights how affect response M. chilensis impact environments counterbalancing its connectivity, concluding that differences should be monitored conserved sustainable practices.

Language: Английский

Citations

0
Epigenomic Insights Into Model Animals and Their Application in Understanding Livestock Systems in Veterinary Science DOI

Neetesh Pandey,

Arvind Yadav

Published: Jan. 1, 2025

Language: Английский

Citations

0
Stress Responses to Changing Environmental Factors in the Domestic Animals: An Epigenetic Perspective DOI Creative Commons
Basavaraj Sajjanar, Narayanan Krishnaswamy, Vijay Kumar Saxena

et al.

Journal of Animal Physiology and Animal Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

ABSTRACT Extreme environmental variations act as stress factors that disturb homeostasis and reduce the fitness of animals. The outcomes responses range from acclimation to adaptation animals stressors. Gene expression patterns shape neuro‐endocrine cellular signalling involved in these responses. Epigenetic modifications are one major gene regulatory mechanisms connect animal response. dynamic well stable modes epigenetic changes carry memory regulation at transgenerational levels. In this review, we highlight involvement domestication process, an captive environment summarize recently identified regulate different factors. We underline possible role developmentally basis for fetal programming methods such thermal conditioning prenatal nutritional interventions. These examples indicate potential scope understanding regulations improving performance domestic

Language: Английский

Citations

0
Promoting health and survival through lowered body temperature DOI
Bruno Conti,

Rafael de Cabo

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Proteomic identification of potential biomarkers for heat tolerance in Caracu beef cattle using high and low thermotolerant groups DOI Creative Commons
Ana Cláudia de Freitas, Henrique G. Reolon, Natalya Gardezani Abduch

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 13, 2024

Heat stress has deleterious effects on physiological and performance traits in livestock. Within this context, using tropically adapted cattle breeds pure herds or terminal crossbreeding schemes to explore heterosis is attractive for increasing animal production warmer climate regions. This study aimed identify biological processes, pathways, potential biomarkers related thermotolerance Caracu, a beef breed, by proteomic analysis of blood plasma. To achieve goal, 61 bulls had their evaluated through heat tolerance index. A subset 14 extreme animals, including the seven most thermotolerant (HIGH group) least (LOW group), plasma samples used liquid chromatography coupled tandem mass spectrometry (LC-MS/MS). The differentially regulated proteins detected between HIGH LOW groups were perform functional enrichment protein-protein interaction network analysis. total 217 only group 51 group. In addition, 81 87 significantly higher lower abundancies group, respectively. Regarding with highest absolute log-fold change values, we highlighted those encoded DUSP5, IGFALS, ROCK2, RTN4, IRAG1, NNT genes based functions. several molecular functions, pathways cellular responses stress, immune system, complement hemostasis both groups, addition terms lipids calcium Protein-protein (PPI) revealed as important nodes many roles response hemostasis, inflammation, homeostasis. Additionally, high values essential PPI herein are thermotolerance, such ADRA1A, APOA1, APOB, APOC3, C4BPA, CAT, CFB, CFH, CLU, CXADR, DNAJB1, DNAJC13, FGA, FGB, FGG, HBA, HBB, HP, HSPD1, KNG1, NNT, OSGIN1, PROC, PROS1, RYR1, TGFB2, VLDLR, VTN, VWF. Identifying biomarkers, mechanisms that act contributes developing strategies improve welfare livestock under tropical climates.

Language: Английский

Citations

1