Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Proteomes, Journal Year: 2024, Volume and Issue: 12(3), P. 25 - 25
Published: Sept. 6, 2024
High-throughput omics technologies have dramatically changed biological research, providing unprecedented insights into the complexity of living systems. This review presents a comprehensive examination current landscape high-throughput pipelines, covering key technologies, data integration techniques and their diverse applications. It looks at advances in next-generation sequencing, mass spectrometry microarray platforms highlights contribution to volume precision. In addition, this critical role bioinformatics tools statistical methods managing large datasets generated by these technologies. By integrating multi-omics data, researchers can gain holistic understanding systems, leading identification new biomarkers therapeutic targets, particularly complex diseases such as cancer. The also electronic health records (EHRs) potential for cloud computing big analytics improve storage, analysis sharing. Despite significant advances, there are still challenges complexity, technical limitations ethical issues. Future directions include development more sophisticated computational application advanced machine learning techniques, which addressing heterogeneity datasets. aims serve valuable resource practitioners, highlighting transformative advancing personalized medicine improving clinical outcomes.
Language: Английский
Citations
14
Medicine in Omics, Journal Year: 2024, Volume and Issue: 11, P. 100039 - 100039
Published: May 21, 2024
Over the last few years, development of so-called omics technologies has greatly contributed to discovery new biomarkers and targets, embracing various fields from diagnostics therapy contributing meliorate advance precision personalized medicine. In addition classic omics, including genomics, transcriptomics, proteomics, metabolomics, newer-generation their platforms, such as microbiomics nutrigenomics, are emerging. parallel, use liquid biopsies, optimal biological samples, consisting in fluids (i.e. blood, saliva, urine) easy collect, whose components (cells, nucleic acids, exosome) can be analysed using throughput techniques, is becoming an attractive, because enables extrapolation big data via multi-omics technologies. Here, we report a brief description discussion technologies, by evidencing applications eventual limitations.
Language: Английский
Citations
11
Sustainability, Journal Year: 2024, Volume and Issue: 16(17), P. 7651 - 7651
Published: Sept. 3, 2024
Abiotic stresses, including drought, salinity, extreme temperatures and nutrient deficiencies, pose significant challenges to crop production global food security. To combat these challenges, the integration of bioinformatics educational tools AI applications provide a synergistic approach identify analyze stress-responsive genes, regulatory networks molecular markers associated with stress tolerance. Bioinformatics offer robust framework for data collection, storage initial analysis, while enhance pattern recognition, predictive modeling real-time processing capabilities. This review uniquely integrates applications, highlighting their combined role in managing abiotic plants crops. The novelty is demonstrated by multiomics algorithms, providing deeper insights into response pathways, biomarker discovery recognition. Key include resistance gene network inference, omics plant monitoring through fusion remote sensing AI-assisted phenomics. Challenges such as handling big data, model interpretability, overfitting experimental validation remain there, but future prospects involve developing user-friendly platforms, establishing common standards, interdisciplinary collaboration harnessing mitigation strategies Educational initiatives, collaborations trainings are essential equip next generation researchers required skills utilize advanced effectively. convergence holds vast accelerating development stress-resilient crops, optimizing agricultural practices ensuring security under increasing environmental pressures. Moreover, this integrated crucial advancing sustainable agriculture amidst growing challenges.
Language: Английский
Citations
10
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102519 - 102519
Published: Sept. 1, 2024
Language: Английский
Citations
4
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 7, 2025
Cancer's epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review discusses the intricate mechanisms underlying cancer epigenetics, unraveling complex interplay between DNA methylation, histone chromatin remodeling, non-coding RNAs. We navigate through tumultuous seas dysregulation, exploring how these processes conspire to silence tumor suppressors unleash oncogenic potential. The narrative pivots cutting-edge technologies, revolutionizing our ability decode epigenome. From granular insights single-cell epigenomics holistic view offered by multi-omics approaches, we examine tools are reshaping understanding heterogeneity evolution. also highlights emerging techniques, such as spatial long-read sequencing, which promise unveil hidden dimensions regulation. Finally, probed transformative potential CRISPR-based epigenome editing computational analysis transmute raw data into biological insights. study seeks synthesize comprehensive yet nuanced contemporary landscape future directions research.
Language: Английский
Citations
0
Intelligence-Based Medicine, Journal Year: 2025, Volume and Issue: 11, P. 100233 - 100233
Published: Jan. 1, 2025
Language: Английский
Citations
0
Quantitative Biology, Journal Year: 2025, Volume and Issue: 13(3)
Published: April 7, 2025
Language: Английский
Citations
0
Brain Organoid and Systems Neuroscience Journal, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1871(3), P. 167637 - 167637
Published: Dec. 23, 2024
With few viable treatment options, glioblastoma (GBM) is still one of the most aggressive and deadly types brain cancer. Recent developments in lipidomics have demonstrated potential lipid metabolism as a therapeutic target GBM. The thorough examination lipids biological systems, or lipidomics, essential to comprehending changed profiles found GBM, which are linked tumor's ability grow, survive, resist treatment. use drug delivery discovery examined this study, focusing on how it may be used find new biomarkers, create multi-target directed ligands, improve systems. We also cover FDA-approved medications, clinical trials that lipid-targeted medicines, integration with other omics technologies. This study emphasizes possible tool developing more effective methods for GBM by exploring various lipid-centric techniques.
Language: Английский
Citations
1
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0